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1.发明申请
公开(公告)号：WO2003099266A2
公开(公告)日：2003-12-04
申请号：PCT/US2003/015868
申请日：2003-05-19
Applicant: ABBOTT LABORATORIES
Inventor： BHATIA, Pramila, A. , DAANEN, Jerome, F. , HAKEEM, Ahmed, A. , KOLASA, Teodozyj , MATULENKO, Mark, A. , MORTELL, Kathleen, H. , PATEL, Meena, V. , STEWART, Andrew, O. , WANG, Xueqing , XIA, Zhiren , ZHANG, Henry, Q.
IPC: A61K31/00
CPC classification number: C07D213/82 , A61K31/40 , A61K31/41 , A61K31/445 , A61K31/4453 , A61K31/4523 , C07D207/06 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/70 , C07D213/74 , C07D213/85 , C07D235/30 , C07D239/42 , C07D277/38 , C07D277/82 , C07D295/13 , C07D295/15 , C07D295/155 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14
Abstract: The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
Abstract translation: 本发明涉及式（I）化合物用于治疗性功能障碍和含有式（I）化合物用于治疗性功能障碍的组合物的用途。
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公开(公告)号：WO2003099266A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/015868
申请日：2003-05-19
Applicant: ABBOTT LABORATORIES
Inventor： BHATIA, Pramila, A. , DAANEN, Jerome, F. , HAKEEM, Ahmed, A. , KOLASA, Teodozyj , MATULENKO, Mark, A. , MORTELL, Kathleen, H. , PATEL, Meena, V. , STEWART, Andrew, O. , WANG, Xueqing , XIA, Zhiren , ZHANG, Henry, Q.
IPC: A61K31/00
Abstract: The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
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公开(公告)号：WO2004060859A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/038906
申请日：2003-12-08
Applicant: ABBOTT LABORATORIES
Inventor： ANDERSON, Steven, N. , BHATIA, Pramila , KOLASA, Teodozyj , NAKANE, Masaki , PATEL, Meena, V. , ROHDE, Jeffrey, J. , XIA, Zhiren , ZHANG, Henry, Q.
IPC: C07C323/00
CPC classification number: C07D213/70 , C07C323/62 , C07D211/16 , C07D211/34 , C07D211/42 , C07D211/46 , C07D211/62
Abstract: Compounds of formula (I) are useful for increasing cGMP levels in a mammal.
Abstract translation: 式（I）化合物可用于增加哺乳动物的cGMP水平。
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公开(公告)号：WO2010083264A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/020964
申请日：2010-01-14
Applicant: ABBOTT LABORATORIES , ZHANG, Qingwei , STEWART, Andrew, O. , XIA, Zhiren
Inventor： ZHANG, Qingwei , STEWART, Andrew, O. , XIA, Zhiren
IPC: C07D211/58 , C07D471/06 , C07D487/06 , A61K31/4985 , A61P25/04 , A61P25/28
CPC classification number: C07D487/04 , C07D211/58 , C07D401/04 , C07D471/04
Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：WO2007140233A1
公开(公告)日：2007-12-06
申请号：PCT/US2007/069630
申请日：2007-05-24
Applicant: ABBOTT LABORATORIES , DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
Inventor： DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
IPC: C07C225/20 , C07D249/14 , C07D277/64 , C07D285/06 , C07D333/20 , A61P35/00 , A61K31/132 , A61K31/505
CPC classification number: C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。
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Patent Agency Ranking
公开(公告)号：WO2005095387A1
公开(公告)日：2005-10-13
申请号：PCT/US2005/009900
申请日：2005-03-24
Applicant: ABBOTT LABORATORIES , MAKOTO, Aoyama , ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
Inventor： MAKOTO, Aoyama , ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC: C07D409/04
CPC classification number: C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
Abstract: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 本发明的化合物可用于抑制蛋白酪氨酸激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号：EP2382191A1
公开(公告)日：2011-11-02
申请号：EP10701070.4
申请日：2010-01-14
Applicant: Abbott Laboratories, Inc.
Inventor： ZHANG, Qingwei , STEWART, Andrew, O. , XIA, Zhiren , JARVIS, Michael F. , SCOTT, Victoria E.
IPC: C07D211/58 , C07D471/06 , C07D487/06 , A61K31/4985 , A61P25/04 , A61P25/28
CPC classification number: C07D487/04 , C07D211/58 , C07D401/04 , C07D471/04
Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：EP2021316A1
公开(公告)日：2009-02-11
申请号：EP07797725.4
申请日：2007-05-24
Applicant: ABBOTT LABORATORIES
Inventor： DIEBOLD, Robert B. , DJURIC, Stevan W. , GIRANDA, Vincent L , HEXAMER, Laura , LIN, Nan-horng , MIYASHIRO, Julie M. , PENNING, Thomas D. , PRZYTULINSKA, Magdalena , SOWIN, Thomas , SULLIVAN, Gerard , TAO, Zhi-fu , TONG, Yunsong , VASUDEVAN, Anil , WANG, Le , WOODS, Keith W. , XIA, Zhiren , ZHANG, Henry Q.
IPC: C07C225/20 , C07D249/14 , C07D277/64 , C07D285/06 , C07D333/20 , A61P35/00 , A61K31/132 , A61K31/505
CPC classification number: C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。 式（I）化合物可用于治疗细胞增殖疾病，例如癌症。
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公开(公告)号：EP1740579A1
公开(公告)日：2007-01-10
申请号：EP05742125.7
申请日：2005-03-24
Applicant: ABBOTT LABORATORIES , Makoto, Aoyama
Inventor： ARNOLD, Lee, D. , DINGES, Jürgen , DIXON, Richard, W. , DJURIC, Stevan, W. , ERICSSON, Anna, M. , FISCHER, Kimba , GASIECKI, Alan, F. , GRACIAS, Vijaya, J. , HOLMS, James, H. , MAKOTO, Aoyama , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , STEINMAN, Douglas, H. , WADA, Carol, K. , XIA, Zhiren , AKRITOPOULOU-ZANZE, Irini , ZHANG, Henry, Q.
IPC: C07D409/04 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/416 , A61P35/00 , A61P37/00 , C07D231/54
CPC classification number: C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
Abstract: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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10.发明公开
公开(公告)号：EP1509213A2
公开(公告)日：2005-03-02
申请号：EP03755402.9
申请日：2003-05-19
Applicant: Abbott Laboratories
Inventor： BHATIA, Pramila, A. , DAANEN, Jerome, F. , HAKEEM, Ahmed, A. , KOLASA, Teodozyj , MATULENKO, Mark, A. , MORTELL, Kathleen, H. , PATEL, Meena, V. , STEWART, Andrew, O. , WANG, Xueqing , XIA, Zhiren , ZHANG, Henry, Q.
IPC: A61K31/00
CPC classification number: A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/427 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4523 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/506
Abstract: The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
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