公开(公告)号：EP2681215B1

公开(公告)日：2015-04-22

申请号：EP12709429.0

申请日：2012-02-28

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  CHEN, Huifen ,  CHICARELLI, Mark Joseph ,  DEMEESE, Jason ,  GARREY, Rustam ,  GAUDINO, John J. ,  KAUS, Robert J. ,  KOLAKOWSKI, Gabrielle R. ,  MARLOW, Allison L. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  SIEDEM, Christopher S. ,  THOMAS, Allen A. ,  WALLACE, Eli ,  WENGLOWSKY, Steven Mark ,  BOYD, Steven

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K45/06 ,  C07D491/052

公开(公告)号：EP2242757A1

公开(公告)日：2010-10-27

申请号：EP09701216.5

申请日：2009-01-08

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James ,  GUNAWARDANA, Indrani W. ,  LE HUEROU, Yvan ,  MOHR, Peter J. ,  WALLACE, Eli M. ,  WANG, Bin

IPC: C07D471/04 ,  A61K31/4162 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP3321262A1

公开(公告)日：2018-05-16

申请号：EP17207123.5

申请日：2013-03-01

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  CHICARELLI, Mark Joseph ,  GARREY, Rustam Ferdinand ,  GAUDINO, John ,  GRINA, Jonas ,  MORENO, David A. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  CHEN, Huifen ,  ROBARGE, Kirk ,  ZHOU, Aihe

IPC: C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596 ,  A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D401/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/65586

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2739618A1

公开(公告)日：2014-06-11

申请号：EP12769775.3

申请日：2012-08-03

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James, F. ,  CHEN, Huifen ,  CHICARELLI, Mark, Joseph ,  DEMEESE, Jason ,  GARREY, Rustam, Ferdinand ,  GAUDINO, John ,  GAZZARD, Lewis ,  KAUS, Robert J. ,  KINTZ, Samuel ,  MOHR, Peter J. ,  MORENO, David, A. ,  SCHWARZ, Jacob ,  SIEDEM, Christopher, S. ,  WALLACE, Eli, M.

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00

CPC classification number: C07D405/14 ,  C07D403/12

Abstract: Compounds having the formula (I) wherein R
1 , R
2 , R
3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

公开(公告)号：EP2681215A1

公开(公告)日：2014-01-08

申请号：EP12709429.0

申请日：2012-02-28

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  CHEN, Huifen ,  CHICARELLI, Mark Joseph ,  DEMEESE, Jason ,  GARREY, Rustam ,  GAUDINO, John J. ,  KAUS, Robert J. ,  KOLAKOWSKI, Gabrielle R. ,  MARLOW, Allison L. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  SIEDEM, Christopher S. ,  THOMAS, Allen A. ,  WALLACE, Eli ,  WENGLOWSKY, Steven Mark

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K45/06 ,  C07D491/052

Abstract: Compounds having the formula I wherein Z, Z1 Z2 Z, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

公开(公告)号：EP2242755B1

公开(公告)日：2012-09-12

申请号：EP09700828.8

申请日：2009-01-08

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James ,  GUNAWARDANA, Indrani W. ,  LE HUEROU, Yvan ,  MOHR, Peter J. ,  WALLACE, Eli M. ,  WANG, Bin

IPC: C07D471/04 ,  A61K31/496 ,  A61P35/00

CPC classification number: C07D471/04