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公开(公告)号：WO2013130976A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028622
申请日：2013-03-01
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
Inventor： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC: C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC classification number: C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 提供式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐，其可用于治疗过度增生，疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：WO2013020062A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049551
申请日：2012-08-03
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James, F. , CHEN, Huifen , CHICARELLI, Mark, Joseph , DEMEESE, Jason , GARREY, Rustam, Ferdinand , GAUDINO, John , GAZZARD, Lewis , KAUS, Robert J. , KINTZ, Samuel , MOHR, Peter J. , MORENO, David, A. , SCHWARZ, Jacob , SIEDEM, Christopher, S. , WALLACE, Eli, M.
Inventor： BLAKE, James, F. , CHEN, Huifen , CHICARELLI, Mark, Joseph , DEMEESE, Jason , GARREY, Rustam, Ferdinand , GAUDINO, John , GAZZARD, Lewis , KAUS, Robert J. , KINTZ, Samuel , MOHR, Peter J. , MORENO, David, A. , SCHWARZ, Jacob , SIEDEM, Christopher, S. , WALLACE, Eli, M.
IPC: C07D403/12 , A61K31/517 , A61P35/00
CPC classification number: C07D405/14 , C07D403/12
Abstract: Compounds having the formula (I) wherein R 1 , R 2 , R 3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Abstract translation: 具有式（I）的化合物，其中本文定义的R1，R2，R3和Ar是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：WO2012118850A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/027009
申请日：2012-02-28
Applicant: ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
Inventor： BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
IPC: C07D471/04 , A61K31/519 , A61P35/00
CPC classification number: C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
Abstract: Compounds having the formula I wherein Z, Z 1 Z 2 Z 3 , R 3a , R 3b and R b and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Abstract translation: 具有式I的化合物，其中Z，Z 1 Z 2 Z 3，R 3a，R 3b和R b如本文所定义是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：WO2009089359A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030450
申请日：2009-01-08
Applicant: ARRAY BIOPHARMA INC. , BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/4162 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：WO2009089352A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030443
申请日：2009-01-08
Applicant: ARRAY BIOPHARMA INC. , BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/496 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.Formula, (I).
Abstract translation: 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。 ）。
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Patent Agency Ranking
公开(公告)号：EP2820009B1
公开(公告)日：2018-01-31
申请号：EP13710222.4
申请日：2013-03-01
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC: C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC classification number: C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP2820009A1
公开(公告)日：2015-01-07
申请号：EP13710222.4
申请日：2013-03-01
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC: C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC classification number: C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 提供式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐，其可用于治疗过度增殖性疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。
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公开(公告)号：EP2242757B1
公开(公告)日：2012-08-01
申请号：EP09701216.5
申请日：2009-01-08
Applicant: Array Biopharma, Inc.
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/4162 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP2242755A1
公开(公告)日：2010-10-27
申请号：EP09700828.8
申请日：2009-01-08
Applicant: Array Biopharma, Inc.
Inventor： BLAKE, James , GUNAWARDANA, Indrani W. , LE HUEROU, Yvan , MOHR, Peter J. , WALLACE, Eli M. , WANG, Bin
IPC: C07D471/04 , A61K31/496 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.Formula, (I).
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公开(公告)号：EP2739618B1
公开(公告)日：2015-09-16
申请号：EP12769775.3
申请日：2012-08-03
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： BLAKE, James, F. , CHEN, Huifen , CHICARELLI, Mark, Joseph , DEMEESE, Jason , GARREY, Rustam, Ferdinand , GAUDINO, John , GAZZARD, Lewis , KAUS, Robert J. , KINTZ, Samuel , MOHR, Peter J. , MORENO, David, A. , SCHWARZ, Jacob , SIEDEM, Christopher, S. , WALLACE, Eli, M.
IPC: C07D405/14 , C07D403/12 , C07D413/14 , A61K31/517 , A61P35/00
CPC classification number: C07D405/14 , C07D403/12
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