公开(公告)号：DD201795A5

公开(公告)日：1983-08-10

申请号：DD23843782

申请日：1982-03-25

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  MUELLER CLAUS D ,  RASCHACK MANFRED ,  PHILIPSBORN GERDA VON

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：FI63403B

公开(公告)日：1983-02-28

申请号：FI781872

申请日：1978-06-12

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  FRIEDRICH LUDWIG ,  HOFMANN HANS PETER ,  KREISKOTT HORST ,  MUELLER CLAUS ,  RASCHACK MANFRED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.

公开(公告)号：CA1105023A

公开(公告)日：1981-07-14

申请号：CA305369

申请日：1978-06-13

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  FRIEDRICH LUDWIG ,  HOFMANN HANS P ,  KREISKOTT HORST ,  MUELLER CLAUS ,  RASCHACK MANFRED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: This invention relates to bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, with the proviso that R1, R2 and R3 cannot all be H when X is 0. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzyl-piperid-4-one with appropriately substituted phenylalkylamines, followed by redustion. They exhibit mainly anto-arrhythmic action.

公开(公告)号：FI71146C

公开(公告)日：1986-11-24

申请号：FI820529

申请日：1982-02-17

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  MUELLER CLAUS D ,  RASCHACK MANFRED ,  PHILIPSBORN GERDA VON

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：AU546256B2

公开(公告)日：1985-08-22

申请号：AU8196282

申请日：1982-03-26

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  MUELLER CLAUS D ,  RASCHACK MANFRED ,  PHILIPSBORN GERDA VON

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：NO821018L

公开(公告)日：1982-09-28

申请号：NO821018

申请日：1982-03-26

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  MUELLER CLAUS D ,  RASCHACK MANFRED ,  PHILIPSBORN GERDA VON

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.