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    N-ACYL DERIVATIVES OF DIPEPTIDES, THEIR PREPARATION AND THEIR USE IN THE THERAPY OF DISORDERS, AND AGENTS FOR THIS PURPOSE
    4.
    发明专利
    N-ACYL DERIVATIVES OF DIPEPTIDES, THEIR PREPARATION AND THEIR USE IN THE THERAPY OF DISORDERS, AND AGENTS FOR THIS PURPOSE 未知

    公开(公告)号：CA1243017A

    公开(公告)日：1988-10-11

    申请号：CA432343

    申请日：1983-07-13

    Applicant: BASF AG

    Inventor： ALBRECHT HANS P ,  KREISKOTT HORST

    IPC: A61K38/00 ,  A61P25/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/08 ,  C07K5/097

    Abstract: The invention relates to novel N-acyl derivatives of dipeptides of the formula X-CO-L-Leu-NH-CH2-CO-R I, where X is a saturated cycloaliphatic hydrocarbon radical of 3 to 10 carbon atoms, indanyl or 1,2,3,4-tetrahydro-naphthyl, in which radicals the carbon atom which is bonded to the carbonyl group can also carry an amino group, or X is L-homoprolyl or a saturated or unsaturated 4-mem-bered, 5-membered or 6-membered heterocyclic ring system containing not more than 2 heteroatoms, and the heterocyclic structure may furthermore be fused to a benzene nucleus, and, where the heterocyclic structure contains nitrogen, it may also contain an oxo or a C1-C3-alkyl group, and R is C1-C5-alkoxy or a radical NR1R2, where R1 and R are identical or different and are each hydrogen or C1-C5-alkyl, but where X a) cannot be pyrrolidin-2-yl or 5-oxopyrrolidin-2-yl, b) cannot be cyclopentyl if R is amino or ethylamino, and c) cannot be 4-thiazolidinyl if R is amino, and its salts with physiologically tolerated acids. These new derivatives are useful for the therapy of disorders.

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