公开(公告)号：DE3933898A1

公开(公告)日：1991-04-18

申请号：DE3933898

申请日：1989-10-11

Applicant: BASF AG

Inventor： MAYWALD VOLKER DR ,  KUEKENHOEHNER THOMAS DR ,  FREUND WOLFGANG DR ,  HAMPRECHT GERHARD DR ,  WUERZER BRUNO DR ,  WESTPHALEN KARL-OTTO DR

IPC: A01N43/80 ,  C07D261/18 ,  C07D275/02 ,  C07D275/03

Abstract: Aminocarbonyl-substd. isoxazole and isothiazole derivs. of formula (Ia)-(Id) are new: X = O or S; R1 = H; halo; 1-6C alkyl; 1-4C alkoxy or alkylthio; benzyl; phenyl; phenoxy or phenylthio; 5-6 membered, satd. or aromatic heterocycle contg. 1 or 2 O, S or N, and opt. substd. by 1 or 2 halo, 1-3C alkyl, alkoxy or alkoxycarbonyl; 3-8C cycloalkyl(1-6C)alkyl; 2-6C alkenyl or alkynyl, both opt. substd. by 1-3 halo or 1-3C alkoxy and/or by one cyclopropyl or phenyl; or 3-8C cycloalkyl or 3-6C cycloalkenyl, both opt. substd. by 1-3 1-4C alkyl or halo; R'1 = 3-8C cycloalkyl(1-6C)alkyl; 2-6C alkenyl or alkynyl as for R1, or 3-6C cycloalkenyl opt. substd. by 1-3 halo or 1-4C alkyl; R2 = HCO, 4,5-dihydrooxazol-2-yl, COYR5 or CONR6R7; Y = O or S; R5 = H; 1-6C alkyl; R3 = H, 1-6C alkyl; R4 = H; OH, 1-4C alkoxy; 1-6C alkyl, etc., their environmentally acceptable salts are included.

公开(公告)号：DK0994112T3

公开(公告)日：2002-09-02

申请号：DK99117240

申请日：1999-09-02

Applicant: BASF AG

Inventor： MAYWALD VOLKER DR ,  HARTMANN HORST ,  GOETZ NORBERT DR ,  REISSENWEBER GERNOT DR ,  KOENIG HARTMANN DR

IPC: C07D307/33 ,  C07D407/04

Abstract: Separation of impurities from 3-(2'-acetoxyethyl)-dihydro-2(3H)-furanone (I) obtained by acetylation of 3-(2'-hydroxyethyl)-dihydro-2(3H)-furanone comprises first separating high boiling impurities and subjecting the recovered distillation head product to a further step in which light and medium boiling components are taken off at the head and recovering pure (I) as the sump product.

公开(公告)号：ES2111661T3

公开(公告)日：1998-03-16

申请号：ES93103978

申请日：1993-03-11

Applicant: BASF AG

Inventor： MAYWALD VOLKER DR ,  KUEKENHOEHNER THOMAS DR ,  MUENSTER PETER DR ,  STAHL STEFAN DR

IPC: C07D261/18

Abstract: Isoxazole-3,4-dicarboxylic acid derivatives of the formula I … … in which the substituents have the following meanings: …… R denotes hydrogen, an alkyl, cycloalkyl or phenyl radical or a 5- to 6-membered heterocyclic radical, it being possible for the organic radicals to have substituents which are inert under the reaction conditions; … R denotes hydrogen, an alkyl, cycloalkyl, benzyl or C3-C6-alkenyl radical; … A denotes an amino group NR R in which R represents hydrogen or an aliphatic or cycloaliphatic radical and R denotes an aliphatic, cycloaliphatic or optionally substituted phenyl radical, or R together with R forms a 4- to 7-membered alkylene chain which can be interrupted by oxygen, sulphur or N-methyl, or denotes a group OR in which R represents an alkyl, cycloalkyl, benzyl or alkenyl radical; … are prepared by deprotonating a CH-acidic compound of the formula II … … by means of a base and reacting the product with hydroxamoyl chlorides of the formula III … … characterised in that the deprotonation is carried out using a magnesium alcoholate of the formula IV… Mg(OR )2IV… in which R denotes an aliphatic or cycloaliphatic radical.

公开(公告)号：ES2058959T3

公开(公告)日：1994-11-01

申请号：ES91103889

申请日：1991-03-14

Applicant: BASF AG

Inventor： KUEKENHOEHNER THOMAS DR ,  MAYWALD VOLKER DR

IPC: C07D261/18

Abstract: Preparation of isoxazole-4,5-dicarboxylic diesters of the general formula I in which R is any desired organic radical which is inert under the reaction conditions and in which R and R each represent an alkyl, cycloalkyl or benzyl group, characterised in that an aldoxime of the general formula II is reacted with a maleic or fumaric diester of the general formula III R OOC-C=C-COOR (III), in which R and R are identical or different and have the abovementioned meaning, in the presence of an aqueous solution of a hypohalite, in which the hypohalite is present in excess, relative to II.

公开(公告)号：ES2058715T3

公开(公告)日：1994-11-01

申请号：ES90118273

申请日：1990-09-24

Applicant: BASF AG

Inventor： KUEKENHOEHNER THOMAS DR ,  FREUND WOLFGANG DR ,  MAYWALD VOLKER DR ,  GOETZ NORBERT DR

IPC: C07D261/18 ,  C07D413/04

公开(公告)号：DE59102595D1

公开(公告)日：1994-09-29

申请号：DE59102595

申请日：1991-03-14

Applicant: BASF AG

Inventor： KUEKENHOEHNER THOMAS DR ,  MAYWALD VOLKER DR

IPC: C07D261/18

Abstract: Preparation of isoxazole-4,5-dicarboxylic diesters of the general formula I in which R is any desired organic radical which is inert under the reaction conditions and in which R and R each represent an alkyl, cycloalkyl or benzyl group, characterised in that an aldoxime of the general formula II is reacted with a maleic or fumaric diester of the general formula III R OOC-C=C-COOR (III), in which R and R are identical or different and have the abovementioned meaning, in the presence of an aqueous solution of a hypohalite, in which the hypohalite is present in excess, relative to II.

公开(公告)号：DE59006894D1

公开(公告)日：1994-09-29

申请号：DE59006894

申请日：1990-09-24

Applicant: BASF AG

Inventor： KUEKENHOEHNER THOMAS DR ,  FREUND WOLFGANG DR ,  MAYWALD VOLKER DR ,  GOETZ NORBERT DR

IPC: C07D261/18 ,  C07D413/04

公开(公告)号：DE4214028A1

公开(公告)日：1993-11-04

申请号：DE4214028

申请日：1992-04-29

Applicant: BASF AG

Inventor： STAHL STEFAN DR ,  MAYWALD VOLKER DR ,  JOERG KLAUS DR

IPC: C07C67/343 ,  C07C69/716

Abstract: In the prodn. of (cyclo)aliphatic beta-ketoesters (I) by reacting a (cyclo)aliphatic methyl ketone (II) with a dialkyl carbonate (III) and a molar excess of alkali metal (m)ethylate (IV) w.r.t. (II), followed by hydrolysis and neutralisation of the reaction prod., the (IV):(II) molar ratio is (1.6-6):1 and the reaction mixt. contains no hexamethyl-phosphoryl triamide (HMPT) as solvent. Pref. (II) is isopropyl methyl ketone (IIA); (III) dimethylcarbonate (IIIA); and (IV) NaOMe. Excess (III) is use, which is expensive and can only be re-used after costly purificn. stages. USE/ADVANTAGE - (I) are valuable intermediates, e.g. for the synthesis of herbicides by base-induced reaction with a hydroxyamic acid chloride to isoxazole derivs. (I) are obtd. in good yields, without the need to use HMPT.

公开(公告)号：DE4009028A1

公开(公告)日：1991-09-26

申请号：DE4009028

申请日：1990-03-21

Applicant: BASF AG

Inventor： KUEKENHOEHNER THOMAS DR ,  MAYWALD VOLKER DR

IPC: C07D261/18

Abstract: Preparation of isoxazole-4,5-dicarboxylic diesters of the general formula I in which R is any desired organic radical which is inert under the reaction conditions and in which R and R each represent an alkyl, cycloalkyl or benzyl group, characterised in that an aldoxime of the general formula II is reacted with a maleic or fumaric diester of the general formula III R OOC-C=C-COOR (III), in which R and R are identical or different and have the abovementioned meaning, in the presence of an aqueous solution of a hypohalite, in which the hypohalite is present in excess, relative to II.

公开(公告)号：ES2181347T3

公开(公告)日：2003-02-16

申请号：ES99117240

申请日：1999-09-02

Applicant: BASF AG

Inventor： MAYWALD VOLKER DR ,  HARTMANN HORST ,  GOTZ NORBERT DR ,  REISSENWEBER GERNOT DR ,  KONIG HARTMANN DR

IPC: C07D307/33 ,  C07D407/04

Abstract: Separation of impurities from 3-(2'-acetoxyethyl)-dihydro-2(3H)-furanone (I) obtained by acetylation of 3-(2'-hydroxyethyl)-dihydro-2(3H)-furanone comprises first separating high boiling impurities and subjecting the recovered distillation head product to a further step in which light and medium boiling components are taken off at the head and recovering pure (I) as the sump product.