公开(公告)号：DE59308002D1

公开(公告)日：1998-02-26

申请号：DE59308002

申请日：1993-03-11

Applicant: BASF AG

Inventor： MAYWALD VOLKER DR ,  KUEKENHOEHNER THOMAS DR ,  MUENSTER PETER DR ,  STAHL STEFAN DR

IPC: C07D261/18

Abstract: Isoxazole-3,4-dicarboxylic acid derivatives of the formula I … … in which the substituents have the following meanings: …… R denotes hydrogen, an alkyl, cycloalkyl or phenyl radical or a 5- to 6-membered heterocyclic radical, it being possible for the organic radicals to have substituents which are inert under the reaction conditions; … R denotes hydrogen, an alkyl, cycloalkyl, benzyl or C3-C6-alkenyl radical; … A denotes an amino group NR R in which R represents hydrogen or an aliphatic or cycloaliphatic radical and R denotes an aliphatic, cycloaliphatic or optionally substituted phenyl radical, or R together with R forms a 4- to 7-membered alkylene chain which can be interrupted by oxygen, sulphur or N-methyl, or denotes a group OR in which R represents an alkyl, cycloalkyl, benzyl or alkenyl radical; … are prepared by deprotonating a CH-acidic compound of the formula II … … by means of a base and reacting the product with hydroxamoyl chlorides of the formula III … … characterised in that the deprotonation is carried out using a magnesium alcoholate of the formula IV… Mg(OR )2IV… in which R denotes an aliphatic or cycloaliphatic radical.

公开(公告)号：ES2111661T3

公开(公告)日：1998-03-16

申请号：ES93103978

申请日：1993-03-11

Applicant: BASF AG

Inventor： MAYWALD VOLKER DR ,  KUEKENHOEHNER THOMAS DR ,  MUENSTER PETER DR ,  STAHL STEFAN DR

IPC: C07D261/18

Abstract: Isoxazole-3,4-dicarboxylic acid derivatives of the formula I … … in which the substituents have the following meanings: …… R denotes hydrogen, an alkyl, cycloalkyl or phenyl radical or a 5- to 6-membered heterocyclic radical, it being possible for the organic radicals to have substituents which are inert under the reaction conditions; … R denotes hydrogen, an alkyl, cycloalkyl, benzyl or C3-C6-alkenyl radical; … A denotes an amino group NR R in which R represents hydrogen or an aliphatic or cycloaliphatic radical and R denotes an aliphatic, cycloaliphatic or optionally substituted phenyl radical, or R together with R forms a 4- to 7-membered alkylene chain which can be interrupted by oxygen, sulphur or N-methyl, or denotes a group OR in which R represents an alkyl, cycloalkyl, benzyl or alkenyl radical; … are prepared by deprotonating a CH-acidic compound of the formula II … … by means of a base and reacting the product with hydroxamoyl chlorides of the formula III … … characterised in that the deprotonation is carried out using a magnesium alcoholate of the formula IV… Mg(OR )2IV… in which R denotes an aliphatic or cycloaliphatic radical.

公开(公告)号：DE4214028A1

公开(公告)日：1993-11-04

申请号：DE4214028

申请日：1992-04-29

Applicant: BASF AG

Inventor： STAHL STEFAN DR ,  MAYWALD VOLKER DR ,  JOERG KLAUS DR

IPC: C07C67/343 ,  C07C69/716

Abstract: In the prodn. of (cyclo)aliphatic beta-ketoesters (I) by reacting a (cyclo)aliphatic methyl ketone (II) with a dialkyl carbonate (III) and a molar excess of alkali metal (m)ethylate (IV) w.r.t. (II), followed by hydrolysis and neutralisation of the reaction prod., the (IV):(II) molar ratio is (1.6-6):1 and the reaction mixt. contains no hexamethyl-phosphoryl triamide (HMPT) as solvent. Pref. (II) is isopropyl methyl ketone (IIA); (III) dimethylcarbonate (IIIA); and (IV) NaOMe. Excess (III) is use, which is expensive and can only be re-used after costly purificn. stages. USE/ADVANTAGE - (I) are valuable intermediates, e.g. for the synthesis of herbicides by base-induced reaction with a hydroxyamic acid chloride to isoxazole derivs. (I) are obtd. in good yields, without the need to use HMPT.

公开(公告)号：DE59401489D1

公开(公告)日：1997-02-20

申请号：DE59401489

申请日：1994-02-25

Applicant: BASF AG

Inventor： STAHL STEFAN DR ,  HARDER WOLFGANG DR ,  HOEHN ARTHUR DR

IPC: B01J31/20 ,  C07B61/00 ,  C07C253/30 ,  C07C255/19

Abstract: 5-Cyanovaleric acid esters (I) are prepared by carbonylating a 1-cyanobutene with carbon monoxide and with an alkanol (II) which corresponds to the ester radical, at elevated temperature and elevated pressure in the presence of a cobalt catalyst and in the presence of an activating solvent, using a carbonic acid diester, a carbamic acid ester or a urea of the general formulae IIIa, IIIb and IIIc R-O-CO-O-R (IIIa> R2N-CO-O-R (IIIb> R2N-CO-NR2 (IIIc> or mixtures of these compounds (R identical or different, C1- to C6-alkyl groups, C5- to C7-cycloalkyl groups, or together 5- to 7-membered rings), in such amounts that they act as the activating solvent. The process products I are used as intermediates, mainly for the preparation of epsilon -caprolactam.

公开(公告)号：DE4306507A1

公开(公告)日：1994-09-08

申请号：DE4306507

申请日：1993-03-03

Applicant: BASF AG

Inventor： STAHL STEFAN DR ,  HARDER WOLFGANG DR ,  HOEHN ARTHUR DR

IPC: B01J31/20 ,  C07B61/00 ,  C07C253/30 ,  C07C255/19

Abstract: 5-Cyanovaleric acid esters (I) are prepared by carbonylating a 1-cyanobutene with carbon monoxide and with an alkanol (II) which corresponds to the ester radical, at elevated temperature and elevated pressure in the presence of a cobalt catalyst and in the presence of an activating solvent, using a carbonic acid diester, a carbamic acid ester or a urea of the general formulae IIIa, IIIb and IIIc R-O-CO-O-R (IIIa> R2N-CO-O-R (IIIb> R2N-CO-NR2 (IIIc> or mixtures of these compounds (R identical or different, C1- to C6-alkyl groups, C5- to C7-cycloalkyl groups, or together 5- to 7-membered rings), in such amounts that they act as the activating solvent. The process products I are used as intermediates, mainly for the preparation of epsilon -caprolactam.

公开(公告)号：DE4209848A1

公开(公告)日：1993-09-30

申请号：DE4209848

申请日：1992-03-26

Applicant: BASF AG

Inventor： MAYWALD VOLKER DR ,  KUEKENHOEHNER THOMAS DR ,  MUENSTER PETER DR ,  STAHL STEFAN DR

IPC: C07D261/18 ,  C07D261/10

Abstract: Isoxazole-3,4-dicarboxylic acid derivatives of the formula I … … in which the substituents have the following meanings: …… R denotes hydrogen, an alkyl, cycloalkyl or phenyl radical or a 5- to 6-membered heterocyclic radical, it being possible for the organic radicals to have substituents which are inert under the reaction conditions; … R denotes hydrogen, an alkyl, cycloalkyl, benzyl or C3-C6-alkenyl radical; … A denotes an amino group NR R in which R represents hydrogen or an aliphatic or cycloaliphatic radical and R denotes an aliphatic, cycloaliphatic or optionally substituted phenyl radical, or R together with R forms a 4- to 7-membered alkylene chain which can be interrupted by oxygen, sulphur or N-methyl, or denotes a group OR in which R represents an alkyl, cycloalkyl, benzyl or alkenyl radical; … are prepared by deprotonating a CH-acidic compound of the formula II … … by means of a base and reacting the product with hydroxamoyl chlorides of the formula III … … characterised in that the deprotonation is carried out using a magnesium alcoholate of the formula IV… Mg(OR )2IV… in which R denotes an aliphatic or cycloaliphatic radical.