12.
    发明专利
    未知

    公开(公告)号:DE4138820A1

    公开(公告)日:1993-05-27

    申请号:DE4138820

    申请日:1991-11-26

    Applicant: BASF AG

    Abstract: Quinoline-3-carboxamides I in which the substituents have the following meaning: R is hydrogen, alkyl, alkenyl, alkynyl or cycloalkyl, where the abovementioned organic radicals can in each case be substituted; R is hydrogen, hydroxyl, alkoxy, alkenyloxy, dialkylamino, alkyl, alkenyl, alkynyl or cycloalkyl, where the abovementioned organic radicals can in each case be substituted; or R and R together are an alkylene chain having 4 to 7 members which can be interrupted by oxygen, sulphur or N-methyl; R -R are hydrogen, alkyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, halogen, cyano or nitro; X is oxygen or sulphur; with the proviso that R is not hydrogen, C1-C3-alkyl, n-butyl, 3-methylbutyl, cyclohexyl, hexyl, heptyl, octyl, 2-chlorobenzyl, 3-(dimethylamino)propyl, 3-(diethylamino)propyl, 2-morpholinoethyl and 2-(3,4-dimethoxyphenyl)ethyl if R and R to R are hydrogen and X is oxygen, and R is not benzyl if R is methyl, R to R are hydrogen and X is oxygen, and R and R together are not morpholino if R to R are hydrogen and X is oxygen.

    15.
    发明专利
    未知

    公开(公告)号:DE19517421A1

    公开(公告)日:1996-11-14

    申请号:DE19517421

    申请日:1995-05-12

    Applicant: BASF AG

    Abstract: A process for preparing enantiomer-pure cis1-amino-2-hydroxyindane is characterised in that: (a) racemic trans1-aminoindan-2-ol is reacted according to known processes with acids or acid derivatives having the general formula RCOX, yielding type (A) amides, in which the substituents have the following meanings: R stands for hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl and phenyl, groups that may carry one to three halogen atoms and/or one to three among the following residues: cyano, C1-C6 alkoxy, C1-C6 alkylthio phenyl, phenylthio and phenoxy, the phenyl residues in turn carrying one to three among the following groups: C1-C4 alkyl, C1-C4 alkoxy, halogen, cyano and nitro; X stands for OH, halogen, OR and SR , in which R stands for alkyl C1-C6, phenyl and COR. In a second step (b), a supersaturated solution or melt of racemic amide (A) is blended with seed crystals of an enantiomer, then (c) the precipitated crystals are isolated and the remaining mother liquor or melt is again supersaturated, after separation of racemic amide (A), and blended with seed crystals of the other enantiomer in order to selectively crystallise said enantiomer. Finally (d), the thus obtained enantiomer-pure transamide is reacted according to known methods to yield enantiomer-pure cis1-amino-2-hydroxyindane.

    16.
    发明专利
    未知

    公开(公告)号:DE59207118D1

    公开(公告)日:1996-10-17

    申请号:DE59207118

    申请日:1992-11-12

    Applicant: BASF AG

    Abstract: Quinoline-3-carboxamides I in which the substituents have the following meaning: R is hydrogen, alkyl, alkenyl, alkynyl or cycloalkyl, where the abovementioned organic radicals can in each case be substituted; R is hydrogen, hydroxyl, alkoxy, alkenyloxy, dialkylamino, alkyl, alkenyl, alkynyl or cycloalkyl, where the abovementioned organic radicals can in each case be substituted; or R and R together are an alkylene chain having 4 to 7 members which can be interrupted by oxygen, sulphur or N-methyl; R -R are hydrogen, alkyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, halogen, cyano or nitro; X is oxygen or sulphur; with the proviso that R is not hydrogen, C1-C3-alkyl, n-butyl, 3-methylbutyl, cyclohexyl, hexyl, heptyl, octyl, 2-chlorobenzyl, 3-(dimethylamino)propyl, 3-(diethylamino)propyl, 2-morpholinoethyl and 2-(3,4-dimethoxyphenyl)ethyl if R and R to R are hydrogen and X is oxygen, and R is not benzyl if R is methyl, R to R are hydrogen and X is oxygen, and R and R together are not morpholino if R to R are hydrogen and X is oxygen.

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