公开(公告)号：NO20000665L

公开(公告)日：2000-02-10

申请号：NO20000665

申请日：2000-02-10

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  KOSER STEFAN ,  SCHOFER BERND ,  THYES MARCO ,  HOEGER THOMAS

IPC: A61K20060101 ,  A61K31/395 ,  C07D239/56 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：NO995939A

公开(公告)日：1999-12-03

申请号：NO995939

申请日：1999-12-03

Applicant: BASF AG

Inventor： SCHOFER BERND

IPC: C07D405/12 ,  C07D207/20 ,  C07D207/22 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D417/12 ,  C07D207/22

公开(公告)号：NO305800B1

公开(公告)日：1999-07-26

申请号：NO961544

申请日：1996-04-18

Applicant: BASF AG

Inventor： SCHOFER BERND ,  MAYER HORST

IPC: C07D251/46 ,  B01J27/122 ,  B01J27/138 ,  B01J31/04 ,  B01J31/22 ,  C07D251/16

Abstract: PCT No. PCT/EP94/03331 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Oct. 10, 1994 PCT Pub. No. WO95/11237 PCT Pub. Date Apr. 27, 1995A process for preparing asymmetrically substituted triazines of the formula I I where R1 is hydrogen, methyl or ethyl, R2 and R3 independently of one another are an unsubstituted or substituted hydrocarbon radical, by reaction of a cyanoguanidine of the formula II II with a carboxylic acid derivative in the presence of an alcohol of the formula III R2-OHIII,which comprises reacting a carboxylic acid ester of the formula IV R3-COOR4IV,where R3 has the abovementioned meaning and R4 is an unsubstituted or substituted hydrocarbon radical, in the presence of a base or of a carboxamide selected from the group consisting of N,N-dialkylformamide, N,N-dialkylacetamide and N-methylpyrrolidone and in the presence of a salt or of a salt-like compound of the elements magnesium, calcium, aluminum, zinc, copper, iron, cobalt, nickel or chromium, is described.

公开(公告)号：NO991010D0

公开(公告)日：1999-03-02

申请号：NO991010

申请日：1999-03-02

Applicant: BASF AG

Inventor： SCHOFER BERND ,  ZIERKE THOMAS

IPC: C07D213/81 ,  C07B43/00 ,  C07C257/10 ,  C07D213/73 ,  C07D213/78 ,  C07D271/06 ,  C07D401/12 ,  C07D413/12 ,  C07K1/06 ,  C07K5/062 ,  C07D

Abstract: A process for preparing amidines and their salts with inorganic or organic acids comprises reacting the corresponding nitrile with ammonia, C1-C6-alkylamine or hydrazine in the presence of a mercaptocarboxylic acid and in the presence or absence of an in-organic or organic ammonium salt.