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    3.
    发明专利
    未知

    公开(公告)号：DE50007472D1

    公开(公告)日：2004-09-23

    申请号：DE50007472

    申请日：2000-01-15

    Applicant: BASF AG

    Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  SCHNEIDER ULRICH

    IPC: B01D11/04 ,  A61K31/215 ,  A61P13/04 ,  A61P13/06 ,  C07C227/38 ,  C07C227/40 ,  C07C229/46 ,  C07C229/48

    Abstract: A process for reducing the content of ethyl 3-dimethylamino-2-phenylpropionate in a solution, contaminated therewith, of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate in a water-immiscible solvent, which comprises adding from 0.5 to 2.0 equivalents of a carboxylic acid per mole of ethyl 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxylate to this solution, and stirring this mixture at a temperature of from 50° C. to 100° C., is described.

    4.
    发明专利
    未知

    公开(公告)号：PT1104397E

    公开(公告)日：2004-05-31

    申请号：PT99940069

    申请日：1999-07-28

    Applicant: BASF AG

    Inventor： THYES MARCO ,  FALKENBERG WOLFGANG ,  WENZ CONNY ,  SCHNEIDER ULRICH

    IPC: C07B61/00 ,  C07C67/343 ,  C07C69/618

    Abstract: A process for preparing ethyl atropate by reacting ethyl phenylacetate with paraformaldehyde in the presence of a base is described and entails employing as ethyl phenylacetate a product which contains not more than 0.03% of the corresponding methyl phenylacetate, and carrying out the reaction in N-methyl-pyrrolidone or N,N-dimethylformamide.

    5.
    发明专利
    未知

    公开(公告)号：AT260883T

    公开(公告)日：2004-03-15

    申请号：AT99940069

    申请日：1999-07-28

    Applicant: BASF AG

    Inventor： FALKENBERG WOLFGANG ,  THYES MARCO ,  WENZ CONNY ,  SCHNEIDER ULRICH

    IPC: C07B61/00 ,  C07C67/343 ,  C07C69/618

    Abstract: A process for preparing ethyl atropate by reacting ethyl phenylacetate with paraformaldehyde in the presence of a base is described and entails employing as ethyl phenylacetate a product which contains not more than 0.03% of the corresponding methyl phenylacetate, and carrying out the reaction in N-methyl-pyrrolidone or N,N-dimethylformamide.

    6.
    发明专利
    未知

    公开(公告)号：TR200102730T2

    公开(公告)日：2002-06-21

    申请号：TR200102730

    申请日：2000-03-06

    Applicant: BASF AG

    Inventor： KLEIN PETER ,  THYES MARCO

    IPC: A61K31/517 ,  A61P9/12 ,  C07D405/12

    Abstract: The invention relates to a method for producing doxazosin mesylate in the modification A. The method is characterised in that doxazosin and methane sulphonic acid are dissolved in a mixture containing an aprotic, polar organic solvent and methanol. Any clouding in the resulting solution is optionally eliminated. The clear solution thus produced is optionally injected with doxazosin mesylate crystals of form A, heated and isolated after the resulting product has been cooled. Said product is then washed with an organic solvent and dried.

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