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公开(公告)号:CA2138287C
公开(公告)日:2005-03-01
申请号:CA2138287
申请日:1993-06-08
Applicant: BASF AG
Inventor: STEINER GERD , UNGER LILIANE , BEHL BERTHOLD , TESCHENDORF HANS-JUERGEN
IPC: C07D401/04 , A61K31/40 , A61K31/403 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/445 , A61P25/00 , A61P25/02 , A61P25/20 , A61P43/00 , C07D209/52 , C07D409/04 , A61K31/44 , C07D403/04
Abstract: Compounds of the formula I: (See formula I) in which the substituents have the meanings stated in the description, and their preparation are described. These novel compounds are suitable as neuroleptics, antidepressants, sedatives, hypnotics, CNS protectives or muscle relaxants.
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12.
公开(公告)号:SK283039B6
公开(公告)日:2003-02-04
申请号:SK23099
申请日:1997-08-22
Applicant: BASF AG
Inventor: STEINER GERD , LUBISCH WILFRIED , BACH ALFRED , EMLING FRANZ , WICKE KARSTEN , TESCHENDORF HANS-JURGEN , BEHL BERTHOLD , KERRRIGAN FRANK , CHEETHAM SHARON
IPC: A61K31/435 , A61K31/519 , A61P25/24 , A61P43/00 , C07D211/00 , C07D239/00 , C07D333/00 , C07D495/14
Abstract: The invention concerns 3-substituted 3,4,5,6,7,8-hexahydro- pyrid3':4,5]thieno-[2,3-d]pyrimidine derivatives of formula (I), their physiologically acceptable salts and use in the therapy.
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13.
公开(公告)号:SI1025100T1
公开(公告)日:2002-10-31
申请号:SI9830101
申请日:1998-10-05
Applicant: BASF AG
Inventor: LUBISCH WILFRIED , DULLWEBER UTA , STARCK DOROTHEA , STEINER GERD , BACH ALFRED , EMLING FRANZ , GARCIA-LADONA XAVIER , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D471/00
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公开(公告)号:MXPA01006987A
公开(公告)日:2002-09-18
申请号:MXPA01006987
申请日:2000-01-11
Applicant: BASF AG
Inventor: STEINER GERD
IPC: A61K31/519 , A61K45/00 , A61P9/10 , A61P25/00 , G01N33/50 , A61P25/08 , A61P25/18 , A61P25/28 , A61P35/00 , C07D495/14 , G01N33/15 , G01N33/566 , A61K31/505
Abstract: La invencion presente se refiere al uso de las contrapartes de union para los receptores 5- HT5 para el tratamiento de trastornos neuropatologicos, en particular, neurodegenerativos y/o neurosiquiatricos que pueden ocurrir, en particular, en isquemia cerebral, accidente cerebrovascular, epilepsia y convulsiones en general, esquizofrenia cronica, otros trastornos sicoticos, demencia, en particular demencia de Alzheimer, trastornos demielinizantes, en particular esclerosis multiple y tumores cerebrales. La invencion tambien se refiere a los procesos para la identificacion y caracterizacion de tales contrapartes de union, en particular en la forma de procesos de deteccion.
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15.
公开(公告)号:AU749320B2
公开(公告)日:2002-06-20
申请号:AU7917698
申请日:1998-05-29
Applicant: BASF AG
Inventor: STEINER GERD , DULLWEBER UTA , STARCK DOROTHEA , BACH ALFRED , WICKE KARSTEN , TESCHENDORF HANS-JURGEN , GARCIA-LADONA FRANCISCO-JAVIER , EMLING FRANZ
IPC: A61K31/495 , A61K31/519 , A61P25/00 , A61P25/24 , A61P43/00 , C07D495/04
Abstract: PCT No. PCT/EP98/03230 Sec. 371 Date Dec. 6, 1999 Sec. 102(e) Date Dec. 6, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56792 PCT Pub. Date Dec. 17, 19983-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives of the formula I where R1 and R2 are a hydrogen atom or a C1-C4-alkyl group, R3 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which may be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups, and may contain 1 nitrogen atom, or to a 5- or 6-membered ring, which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it being possible for the linkage between Y and Z also to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.
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公开(公告)号:PL348920A1
公开(公告)日:2002-06-17
申请号:PL34892099
申请日:1999-12-24
Applicant: BASF AG
Inventor: STEINER GERD , SCHELLHAAS KURT , LUBISCH WILFRIED , HOLZENKAMP UTA , STARCK DOROTHEA , KNOPP MONIKA , SZABO LASZLO , EMLING FRANZ , GARCIA-LADONA FRANCISCO JAVIER , HOFMANN HANS-PETER , UNGER LILIANE
IPC: C07D495/04 , A61K31/505 , A61K31/519 , A61P9/10 , C07D495/14 , A61K31/495
Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.
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公开(公告)号:PL348916A1
公开(公告)日:2002-06-17
申请号:PL34891699
申请日:1999-12-22
Applicant: BASF AG
Inventor: STEINER GERD , SCHELLHAAS KURT , LUBISCH WILFRIED , HOLZENKAMP UTA , STARCK DOROTHEA , SZABO LASZLO , EMLING FRANZ , GARCIA-LADONA FRANCISCO JAVIER , HOFMANN HANS-PETER , UNGER LILIANE
IPC: C07D275/06 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/551 , A61P9/10 , A61P25/28 , C07D401/12 , C07D417/12 , C07D471/04 , A61K31/428
Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.
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公开(公告)号:CZ20012485A3
公开(公告)日:2002-04-17
申请号:CZ20012485
申请日:1999-12-24
Applicant: BASF AG
Inventor: STEINER GERD , ACHELLHAAS KURT , LUBISCH WILFRIED , HOLZENKAMP UTA , STARCK DOROTHEA , KNOPP MONIKA , SZABO LASZLO , EMLING FRANZ , HOFMANN HANS-PETER , GARCIA-LADONA FRANCISCO JAVIER , UNGER LILIANE
IPC: C07D495/04 , A61K31/505 , A61K31/519 , A61P9/10 , C07D495/14 , A61K31/55
Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.
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公开(公告)号:NO312243B1
公开(公告)日:2002-04-15
申请号:NO970473
申请日:1997-02-03
Applicant: BASF AG
Inventor: STEINER GERD , MUNSCHAUER RAINER , HOEGER THOMAS , UNGER LILIANE , TESCHENDORF HANS-JUERGEN
IPC: C07D401/06 , A61K31/40 , A61K31/415 , A61K31/47 , A61K31/505 , A61P25/18 , A61P43/00 , C07D403/06 , C07D471/04 , C07D513/04 , A61K31/506
Abstract: PCT No. PCT/EP95/02893 Sec. 371 Date Sep. 18, 1997 Sec. 102(e) Date Sep. 18, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/04272 PCT Pub. Date Feb. 15, 1996N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) in which R1, R2, A, X, Y and Z have the meanings given in the description, their method of preparation and their use as pharmacological agents.
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公开(公告)号:DE59802922D1
公开(公告)日:2002-03-14
申请号:DE59802922
申请日:1998-10-05
Applicant: BASF AG
Inventor: LUBISCH WILFRIED , DULLWEBER UTA , STARCK DOROTHEA , STEINER GERD , BACH ALFRED , EMLING FRANZ , GARCIA-LADONA XAVIER , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/519 , A61P1/00 , A61P1/14 , A61P3/04 , A61P5/00 , A61P9/12 , A61P15/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D471/00 , C07D471/04
Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.
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