公开(公告)号：NO991678A

公开(公告)日：1999-04-12

申请号：NO991678

申请日：1999-04-09

Applicant: WARNER LAMBERT CO ,  BASF AG

Inventor： ALLEN HAMISH JOHN ,  BRADY KENNETH DALE ,  HARTER WILLIAM GLEN ,  LUNNEY ELIZABETH ANN ,  PLUMMER MARK STEPHEN ,  SAWYER TOMI ,  SHAHRIPOUR AURASH ,  WALKER NIGEL

IPC: A61K31/192 ,  A61K31/341 ,  A61P1/00 ,  A61P7/08 ,  A61P19/02 ,  A61P25/28 ,  A61P31/04 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07D307/12 ,  A61K31/195

CPC classification number: C07D307/12 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07C2601/14 ,  C07C2602/10

公开(公告)号：CA2268098A1

公开(公告)日：1998-04-23

申请号：CA2268098

申请日：1997-10-09

Applicant: BASF AG ,  WARNER LAMBERT CO

Inventor： HARTER WILLIAM GLEN ,  THOMAS ANTHONY JEROME ,  BRADY KENNETH DALE ,  GILMORE JOHN LODGE ,  CAPRATHE BRADLEY WILLIAM ,  ALBRECHT HANS-PETER ,  PARA KIMBERLY SUZANNE ,  LUNNEY ELIZABETH ANN ,  KOSTLAN CATHERINE ROSE ,  HAYS SHERYL JEANNE ,  ALLEN HAMISH JOHN ,  WALKER NIGEL

IPC: C07D233/34 ,  A61K31/22 ,  A61K31/222 ,  A61K31/341 ,  A61K31/343 ,  A61K31/381 ,  A61K31/40 ,  A61K31/405 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/472 ,  A61K31/505 ,  A61K38/00 ,  A61P1/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/10 ,  A61P43/00 ,  C07C233/47 ,  C07C233/50 ,  C07C233/51 ,  C07C271/22 ,  C07C275/16 ,  C07C275/60 ,  C07C311/03 ,  C07C311/06 ,  C07C311/19 ,  C07C317/04 ,  C07C317/44 ,  C07C323/52 ,  C07C327/32 ,  C07D207/08 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D207/28 ,  C07D207/48 ,  C07D209/08 ,  C07D209/18 ,  C07D211/34 ,  C07D211/76 ,  C07D211/96 ,  C07D213/55 ,  C07D213/75 ,  C07D217/24 ,  C07D233/36 ,  C07D233/64 ,  C07D239/10 ,  C07D277/64 ,  C07D307/68 ,  C07D307/79 ,  C07D307/80 ,  C07D333/22 ,  C07D333/24 ,  C07D333/38 ,  C07D333/54 ,  C07D333/60 ,  C07K5/00 ,  C07K5/02 ,  C07K5/093

Abstract: The present invention relates to compounds that are inhibitors of interleukin1.beta. converting enzyme that have formula (I). This invention also relates to a method of treatment of stroke, inflammatory diseases, reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin1.beta. converting enzyme.

公开(公告)号：CA2005058A1

公开(公告)日：1990-06-12

申请号：CA2005058

申请日：1989-12-11

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  DAUM LOTHAR ,  HAUPT ANDREAS ,  SCHMIED BERNHARD ,  WALKER NIGEL ,  ZECHEL JOHANN-CHRISTIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/52 ,  C07K14/525 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/19 ,  C07K7/50

Abstract: Peptides of the formula X-A-Gly-Asp-Y, where A, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.

公开(公告)号：NO315042B1

公开(公告)日：2003-06-30

申请号：NO991678

申请日：1999-04-09

Applicant: BASF AG

Inventor： ALLEN HAMISH JOHN ,  BRADY KENNETH DALE ,  HARTER WILLIAM GLEN ,  LUNNEY ELIZABETH ANN ,  PLUMMER MARK STEPHEN ,  SAWYER TOMI ,  SHAHRIPOUR AURASH ,  WALKER NIGEL

IPC: A61K31/192 ,  A61K31/341 ,  A61P1/00 ,  A61P7/08 ,  A61P19/02 ,  A61P25/28 ,  A61P31/04 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07D307/12 ,  A61K31/195

Abstract: PCT No. PCT/US97/18406 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 9, 1997 PCT Pub. No. WO98/16504 PCT Pub. Date Apr. 23, 1998The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have the Formula I, II, or III. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme.

公开(公告)号：AU7077400A

公开(公告)日：2001-03-26

申请号：AU7077400

申请日：2000-08-25

Applicant: BASF AG ,  GPC BIOTECH INC

Inventor： TAYLOR NEIL R ,  BORHANI DAVID ,  EPSTEIN DAVID ,  RUDOLPH JOHANNES ,  RITTER KURT ,  FUJIMORI TARO ,  ROBINSON SIMON ,  ECKSTEIN JENS ,  HAUPT ANDREAS ,  WALKER NIGEL ,  DIXON RICHARD W ,  CHOQUETTE DEBORAH ,  BLANCHARD JILL ,  KLUGE ARTHUR ,  PAL KOLLOL ,  BOCKOVICH NICHOLAS ,  COME JON ,  HEDIGER MARK

IPC: C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61P9/08 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K5/10 ,  C07K5/107 ,  C12N9/16 ,  C12N9/99 ,  C12N15/55 ,  A61K38/43

公开(公告)号：BR9713314A

公开(公告)日：2000-01-25

申请号：BR9713314

申请日：1997-10-09

Applicant: WARNER LAMBERT CO ,  BASF AG

Inventor： ALLEN HAMISH JOHN ,  BRADY KENNETH DALE ,  HARTER WILLIAM GLEN ,  LUNNEY ELIZABETH ANN ,  PLUMMER MARK STEPHEN ,  SAWYER TOMI ,  SHAHRIPOUR AURASH ,  WALKER NIGEL

IPC: A61K31/192 ,  A61K31/341 ,  A61P1/00 ,  A61P7/08 ,  A61P19/02 ,  A61P25/28 ,  A61P31/04 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07D307/12 ,  C07C311/00

Abstract: PCT No. PCT/US97/18406 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 9, 1997 PCT Pub. No. WO98/16504 PCT Pub. Date Apr. 23, 1998The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have the Formula I, II, or III. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme.

公开(公告)号：NO991678D0

公开(公告)日：1999-04-09

申请号：NO991678

申请日：1999-04-09

Applicant: WARNER LAMBERT CO ,  BASF AG

Inventor： ALLEN HAMISH JOHN ,  BRADY KENNETH DALE ,  HARTER WILLIAM GLEN ,  LUNNEY ELIZABETH ANN ,  PLUMMER MARK STEPHEN ,  SAWYER TOMI ,  SHAHRIPOUR AURASH ,  WALKER NIGEL

IPC: A61K31/192 ,  A61K31/341 ,  A61P1/00 ,  A61P7/08 ,  A61P19/02 ,  A61P25/28 ,  A61P31/04 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07D307/12 ,  A61K31/195

Abstract: PCT No. PCT/US97/18406 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 9, 1997 PCT Pub. No. WO98/16504 PCT Pub. Date Apr. 23, 1998The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have the Formula I, II, or III. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme.

公开(公告)号：CA2268103A1

公开(公告)日：1998-04-23

申请号：CA2268103

申请日：1997-10-09

Applicant: BASF AG ,  WARNER LAMBERT CO

Inventor： LUNNEY ELIZABETH ANN ,  PLUMMER MARK STEPHEN ,  SAWYER TOMI ,  BRADY KENNETH DALE ,  WALKER NIGEL ,  HARTER WILLIAM GLEN ,  SHAHRIPOUR AURASH ,  ALLEN HAMISH JOHN

IPC: A61K31/192 ,  A61K31/341 ,  A61P1/00 ,  A61P7/08 ,  A61P19/02 ,  A61P25/28 ,  A61P31/04 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C323/67 ,  C07D307/12 ,  A61K31/195 ,  A61K31/34 ,  C07C311/42

Abstract: The present invention relates to compounds that are inhibitors of interleukin1.beta. converting enzyme that have Formula (I, II or III). This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.

公开(公告)号：CA2268086A1

公开(公告)日：1998-04-23

申请号：CA2268086

申请日：1997-10-09

Applicant: WARNER LAMBERT CO ,  BASF AG

Inventor： ALLEN HAMISH JOHN ,  BRADY KENNETH DALE ,  HARTER WILLIAM GLEN ,  KOSTLAN CATHERINE ROSE ,  ROTH BRUCE DAVID ,  ALBRECHT HANS-PETER ,  WALKER NIGEL

IPC: A61K31/195 ,  A61K31/473 ,  A61K38/00 ,  A61P9/00 ,  A61P19/02 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00 ,  C07C311/06 ,  C07C311/10 ,  C07C311/13 ,  C07C311/19 ,  C07D217/24 ,  C07K5/06 ,  C07K5/065 ,  C07K5/068 ,  C07K5/072 ,  C07K5/078 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/093 ,  C07K5/097 ,  C07K5/103 ,  C07K5/107 ,  C07K5/11 ,  C07K5/113 ,  C07K5/117 ,  C07K5/062 ,  A61K31/18 ,  C07C311/24

Abstract: The present invention relates to compounds that are inhibitors of interleukin1.beta. converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1.beta. converting enzyme.

公开(公告)号：CA2005061A1

公开(公告)日：1990-06-12

申请号：CA2005061

申请日：1989-12-11

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  DAUM LOTHAR ,  HAUPT ANDREAS ,  SCHMIED BERNHARD ,  WALKER NIGEL ,  ZECHEL JOHANN-CHRISTIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/56 ,  C07K7/64 ,  C07K14/52 ,  C07K14/525 ,  A61K38/08 ,  A61K38/19 ,  A61K38/21 ,  C07K7/50

Abstract: Peptides of the formula X-A-B-Pro-E-Y, where A, B, E, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.