公开(公告)号：WO9006943A3

公开(公告)日：1990-08-09

申请号：PCT/EP8901470

申请日：1989-12-02

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  DAUM LOTHAR ,  HAUPT ANDREAS ,  SCHMIED BERNHARD ,  WALKER NIGEL ,  ZECHEL JOHANN-CHRISTIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/52 ,  C07K14/525 ,  A61K37/02 ,  C07K7/56

CPC classification number: C07K14/525 ,  A61K38/00

Abstract: Peptides derived from TNF, of formula (I): X-A-Gly-Asp-Y, in which A X and Y have the meanings given in the description. Process for producing them. The novel peptides are useful therapeutic agents.

公开(公告)号：BG63697B1

公开(公告)日：2002-09-30

申请号：BG10183597

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS W ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The description relates to compounds of formula in which A, B, D, R' and R have the meanings given in the specification. the compounds am suitable for the treatment of diseases The novel compounds are produced via compounds of the formula H2N-CH2.G-M in which G and M have the meanings given in the specification. 3 claims

公开(公告)号：AT166065T

公开(公告)日：1998-05-15

申请号：AT92913125

申请日：1992-06-23

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  HOEFFKEN HANS WOLFGANG ,  BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  C07K1/113 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078

Abstract: PCT No. PCT/EP92/01411 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/01208 PCT Pub. Date Jan. 21, 1993.2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：HRP950338A2

公开(公告)日：1997-10-31

申请号：HRP950338

申请日：1995-06-14

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：FI973360A

公开(公告)日：1997-08-15

申请号：FI973360

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  C07K

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：FI973282A

公开(公告)日：1997-08-08

申请号：FI973282

申请日：1997-08-08

Applicant: BASF AG

Inventor： SEITZ WERNER ,  MACK HELMUT ,  ZIERKE THOMAS ,  BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  PFEIFFER THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087 ,  C07K

Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.

公开(公告)号：NO972559A

公开(公告)日：1997-08-05

申请号：NO972559

申请日：1997-06-05

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087 ,  A61K38/55

CPC classification number: C07K5/0812 ,  A61K38/00 ,  C07K5/06026 ,  C07K5/06043 ,  C07K5/06078 ,  C07K5/06113

公开(公告)号：SI9520075A

公开(公告)日：1997-06-30

申请号：SI9520075

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07C279/18 ,  C07C279/16 ,  A61K31/395

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：CA2005058A1

公开(公告)日：1990-06-12

申请号：CA2005058

申请日：1989-12-11

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  DAUM LOTHAR ,  HAUPT ANDREAS ,  SCHMIED BERNHARD ,  WALKER NIGEL ,  ZECHEL JOHANN-CHRISTIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/52 ,  C07K14/525 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/19 ,  C07K7/50

Abstract: Peptides of the formula X-A-Gly-Asp-Y, where A, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.

公开(公告)号：PL181405B1

公开(公告)日：2001-07-31

申请号：PL31798995

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS W ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.