公开(公告)号：NO20021382D0

公开(公告)日：2002-03-20

申请号：NO20021382

申请日：2002-03-20

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N

Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

公开(公告)号：CA2385497A1

公开(公告)日：2001-03-29

申请号：CA2385497

申请日：2000-09-21

Applicant: BASF AG

Inventor： HERMANN THERON ,  PERO JANICE G ,  PATTERSON THOMAS A ,  YOCUM ROGERS R

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N9/00 ,  C12N9/10 ,  C12P7/42 ,  C12N15/53 ,  C12N15/54 ,  C12N15/60 ,  C12N15/75

Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate g( a)- decarboxylase overexpressing microorganisms are provided. Methods of produci ng panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously microbial pantothenate kinase gene, coaX, as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaXnucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of th e present invention.

公开(公告)号：HU230509B1

公开(公告)日：2016-09-28

申请号：HU0202705

申请日：2000-09-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C12N15/52 ,  C12N1/21 ,  C12N9/00 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/53 ,  C12N15/54 ,  C12N15/60 ,  C12N15/75 ,  C12P7/42 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125

公开(公告)号：TR200200751T2

公开(公告)日：2004-08-23

申请号：TR200200751

申请日：2000-09-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N15/60 ,  C12N15/75 ,  C12N9/00 ,  C12N8/02 ,  C12P7/42

Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

公开(公告)号：AU2003298508A8

公开(公告)日：2004-05-04

申请号：AU2003298508

申请日：2003-03-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PERO JANICE G ,  WILLIAMS MARK K

IPC: C12N9/00 ,  C12N15/52 ,  C12P17/12

公开(公告)号：AU2003298508A1

公开(公告)日：2004-05-04

申请号：AU2003298508

申请日：2003-03-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  WILLIAMS MARK K ,  PERO JANICE G

IPC: C12N9/00 ,  C12N15/52 ,  C12P17/12

公开(公告)号：SK5222002A3

公开(公告)日：2003-03-04

申请号：SK5222002

申请日：2000-09-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N15/00

Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

公开(公告)号：BR0014115A

公开(公告)日：2002-05-21

申请号：BR0014115

申请日：2000-09-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N9/00

Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

公开(公告)号：AU7708700A

公开(公告)日：2001-04-24

申请号：AU7708700

申请日：2000-09-21

Applicant: BASF AG

Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N9/00

Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.