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    METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS
    1.
    发明申请
    METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS 审中-公开
    用于生产PANTO化合物的方法和微生物

    公开(公告)号：WO0121772A9

    公开(公告)日：2002-12-05

    申请号：PCT/US0025993

    申请日：2000-09-21

    Applicant: BASF AG

    Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

    IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N9/00 ,  C12N9/10 ,  C12N15/53 ,  C12N15/54 ,  C12N15/60 ,  C12N15/75 ,  C12P7/42

    CPC classification number: C12P13/02 ,  C12N9/0006 ,  C12N9/1014 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P7/42 ,  C12P13/06 ,  C12P17/04

    Abstract: The present invention features methods of producing panto-compounds e.g. , pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate g(a)-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

    Abstract translation: 本发明的特征在于生产泛化合物的方法，例如 ，泛酸盐），其中已经操纵了泛酸生物合成途径和/或异亮氨酸 - 缬氨酸生物合成途径和/或辅酶A生物合成途径的微生物。 提供了酮过氧还原酶过表达微生物以及天冬氨酸g（a） - 脱羧酶过表达微生物的方法。 描述了以前体非依赖性方式和高产率生产泛化合物的方法。 还提供了用于实践上述方法的重组微生物，载体，分离的核酸分子，基因和基因产物。 本发明还具有以前的微生物泛酸激酶基因coaX，以及利用具有改良的泛酸激酶活性的微生物产生泛化合物的方法。 重组微生物，载体，分离的coaX核酸分子和纯化的CoaX蛋白。 还特征在于利用本发明的重组微生物和/或纯化的CoaX蛋白鉴定泛酸激酶调节剂的方法。

    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE
    5.
    发明申请
    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE 审中-公开
    增强生物活性的微生物和方法

    公开(公告)号：WO2004005525A3

    公开(公告)日：2006-02-02

    申请号：PCT/US0321305

    申请日：2003-07-03

    Applicant: BASF AG ,  YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

    Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

    IPC: C12N1/21 ,  C12P13/02 ,  C12P1/00 ,  C07H21/04 ,  C12N9/00 ,  C12N9/10 ,  C12P19/02

    CPC classification number: C12N15/52 ,  C12P13/02

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    Abstract translation: 本发明的特征在于利用具有改良的泛酸生物合成酶活性并具有改性的亚甲基四氢叶酸（MTF）生物合成酶活性的微生物增强生产泛酸盐和泛酸盐的改进方法。 特别地，本发明的特征在于通过增加对其合成直接或间接有贡献的酶或底物来增加关键中间体酮托品酸的水平来增加所需产物的产生的方法。 还具有重组微生物和培养条件。 还有这些微生物产生的组合物。

    6.
    发明专利
    未知

    公开(公告)号：AT347589T

    公开(公告)日：2006-12-15

    申请号：AT02709018

    申请日：2002-01-18

    Applicant: BASF AG

    Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

    IPC: C12N15/09 ,  C12N1/21 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12N15/03 ,  C07C235/12

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE
    9.
    发明专利
    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE 未知

    公开(公告)号：CA2491145A1

    公开(公告)日：2004-01-15

    申请号：CA2491145

    申请日：2003-07-03

    Applicant: BASF AG

    Inventor： HERMANN THERON ,  PERO JANICE G ,  YOCUM R ROGERS ,  PATTERSON THOMAS A

    IPC: C12N1/21 ,  C12P13/02

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particula r, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

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