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    METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS
    1.
    发明申请
    METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS 审中-公开
    用于生产PANTO化合物的方法和微生物

    公开(公告)号：WO0121772A9

    公开(公告)日：2002-12-05

    申请号：PCT/US0025993

    申请日：2000-09-21

    Applicant: BASF AG

    Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

    IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N9/00 ,  C12N9/10 ,  C12N15/53 ,  C12N15/54 ,  C12N15/60 ,  C12N15/75 ,  C12P7/42

    CPC classification number: C12P13/02 ,  C12N9/0006 ,  C12N9/1014 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/93 ,  C12N15/52 ,  C12P7/42 ,  C12P13/06 ,  C12P17/04

    Abstract: The present invention features methods of producing panto-compounds e.g. , pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate g(a)-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

    Abstract translation: 本发明的特征在于生产泛化合物的方法，例如 ，泛酸盐），其中已经操纵了泛酸生物合成途径和/或异亮氨酸 - 缬氨酸生物合成途径和/或辅酶A生物合成途径的微生物。 提供了酮过氧还原酶过表达微生物以及天冬氨酸g（a） - 脱羧酶过表达微生物的方法。 描述了以前体非依赖性方式和高产率生产泛化合物的方法。 还提供了用于实践上述方法的重组微生物，载体，分离的核酸分子，基因和基因产物。 本发明还具有以前的微生物泛酸激酶基因coaX，以及利用具有改良的泛酸激酶活性的微生物产生泛化合物的方法。 重组微生物，载体，分离的coaX核酸分子和纯化的CoaX蛋白。 还特征在于利用本发明的重组微生物和/或纯化的CoaX蛋白鉴定泛酸激酶调节剂的方法。

    METHODS AND ORGANISMS FOR PRODUCTION OF B6 VITAMERS
    3.
    发明申请
    METHODS AND ORGANISMS FOR PRODUCTION OF B6 VITAMERS 审中-公开
    生产B6维生素的方法和有机体

    公开(公告)号：WO2004035010A8

    公开(公告)日：2004-06-10

    申请号：PCT/US0308880

    申请日：2003-03-21

    Applicant: BASF AG ,  YOCUM ROGERS R ,  WILLIAMS MARK K ,  PERO JANICE G

    Inventor： YOCUM ROGERS R ,  WILLIAMS MARK K ,  PERO JANICE G

    IPC: C12N9/00 ,  C12N15/52 ,  C12P17/12 ,  C12P25/00 ,  C12N1/12 ,  C12N1/16 ,  C12N1/20 ,  C12N9/10

    CPC classification number: C12N9/00 ,  C12N15/52 ,  C12P17/12

    Abstract: The present invention features methods of producing B6 vitamers that involve culturing an organism overexpressing an enzyme that catalyzes a step in the biosynthesis of a B6 vitamer under conditions such that a B6 vitamer is produced. The present invention further features methods of producing B6 vitamers that involve culturing recombinant microorganisms having increased activity of at least one B6 vitamer biosynthetic enzyme, e.g., YaaD or YaaE, or a homologue thereof, or Epd, PdxA, PdxJ, PdxF, PdxB, PdxH, and/or Dxs , or a homologue thereof.

    Abstract translation: 本发明的特征在于生产B6维生素的方法，其涉及培养在产生B6维生素的条件下过量表达催化B6维生素生物合成步骤的酶的生物体的培养。 本发明还涉及生产B6维生素的方法，其涉及培养具有增加至少一种B6维生素生物合成酶的活性的重组微生物，例如YaaD或YaaE或其同源物，或Epd，PdxA，PdxJ，PdxF，PdxB，PdxH ，和/或Dxs，或其同源物。

    METHODS AND ORGANISMS FOR PRODUCTION OF B6 VITAMERS
    4.
    发明申请
    METHODS AND ORGANISMS FOR PRODUCTION OF B6 VITAMERS 审中-公开
    生产B6维生素的方法和生物

    公开(公告)号：WO2004035010A2

    公开(公告)日：2004-04-29

    申请号：PCT/US0308880

    申请日：2003-03-21

    Applicant: BASF AG ,  YOCUM ROGERS R ,  WILLIAMS MARK K ,  PERO JANICE G

    Inventor： YOCUM ROGERS R ,  WILLIAMS MARK K ,  PERO JANICE G

    IPC: C12N9/00 ,  C12N15/52 ,  C12P17/12 ,  A61K

    CPC classification number: C12N9/00 ,  C12N15/52 ,  C12P17/12

    Abstract: The present invention features methods of producing B6 vitamers that involve culturing an organism overexpressing an enzyme that catalyzes a step in the biosynthesis of a B6 vitamer under conditions such that a B6 vitamer is produced. The present invention further features methods of producing B6 vitamers that involve culturing recombinant microorganisms having increased activity of at least one B6 vitamer biosynthetic enzyme, e.g., YaaD or YaaE, or a homologue thereof, or Epd, PdxA, PdxJ, PdxF, PdxB, PdxH, and/or Dxs , or a homologue thereof.

    Abstract translation: 本发明的特征在于生产B6维生素的方法，所述维生素B6涉及在产生B6维生素的条件下培养过表达酶的生物体，所述酶催化B6维生素的生物合成的步骤。 本发明进一步特征在于生产B6维生素E的方法，所述方法涉及培养具有增加的至少一种B6维生素生物合成酶（例如YaaD或YaaE）或其同源物或Epd，PdxA，PdxJ，PdxF，PdxB，PdxH ，和/或Dxs或其同系物。

    METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS
    9.
    发明专利
    METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS 未知

    公开(公告)号：PL356566A1

    公开(公告)日：2004-06-28

    申请号：PL35656600

    申请日：2000-09-21

    Applicant: BASF AG

    Inventor： YOCUM ROGERS R ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

    IPC: C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125 ,  C12N9/00 ,  C12N15/54 ,  C12P7/42

    Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

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