公开(公告)号：US20190194141A1

公开(公告)日：2019-06-27

申请号：US16292773

申请日：2019-03-05

Applicant: BASF SE

Inventor： Birgit GOCKEL ,  Daniel SAELINGER ,  Sebastian SOERGEL ,  Michael RACK

IPC: C07D231/14 ,  C07D403/12 ,  C07D405/06 ,  C07D401/12

Abstract: The present invention relates to a process for preparing a pyrazole compound of formula V, which comprises cyclizing a hydrazone substituted α,β-unsaturated carbonyl compound of formula IV by reacting it with a suitable reagent, e.g. a reducing agent, an organometallic reagent or a nucleophilic reagent. The compounds of formula V are versatile reaction tools for the preparation of pyrazole derived fine chemicals. The present invention also relates to pyrazole compounds of formulae Va, Vb, Vc, and VI.

公开(公告)号：US20190055200A1

公开(公告)日：2019-02-21

申请号：US16074537

申请日：2017-01-25

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Michael RACK ,  Sebastian SOERGEL ,  Birgit GOCKEL ,  Roland GOETZ

IPC: C07D231/14 ,  B01J21/18 ,  B01J23/42 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention relates to a catalytic process for preparing pyrazoles comprising the step of cyclizing hydrazone substituted α,β-unsaturated carbonyl compounds by reacting them with hydrogen in a reaction mixture comprising as components (a) a hydrogenation catalyst, (b) an acid selected from Brønsted acids, ammonium salts of Brønsted acids, and Lewis acids, (c) a protic solvent, and optionally (d) an aprotic solvent.