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公开(公告)号：AU2007334850C1
公开(公告)日：2014-02-13
申请号：AU2007334850
申请日：2007-12-18
Applicant: BASF SE
Inventor： BOTTNER MEWES , REINDL ANDREAS , LANG CHRISTINE , VEEN MARKUS
Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
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公开(公告)号：BRPI0615829A2
公开(公告)日：2012-12-18
申请号：BRPI0615829
申请日：2006-09-13
Applicant: BASF SE
Inventor： LANG CHRISTINE , VEEN MARKUS , BUDDE ECKHARD , BITTNER MEWES , REINDL ANDREAS , KNILL ROLF
Abstract: Described are microorganisms which are able to suppress the production of malodorous compounds by axillary bacteria. Also described are compositions comprising such microorganisms as well as the use of such micoorganisms in cosmetic, prophylactic or therapeutic applications.
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公开(公告)号：ZA201100199B
公开(公告)日：2012-03-28
申请号：ZA201100199
申请日：2011-01-07
Applicant: BASF SE
Inventor： BOTTNER MEWES , LANG CHRISTINE , VEEN MARKUS , SCHILLING MICHAEL , REINDL ANDREAS
IPC: C12N20060101 , A61K20060101 , C12R20060101
Abstract: Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth of Streptococcus salivarius but does not stimulate the growth of Streptococcus mutans and/or Porphyromonas gingivalis. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.
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公开(公告)号：CA2724769A1
公开(公告)日：2009-12-17
申请号：CA2724769
申请日：2009-05-19
Applicant: BASF SE
Inventor： BOETTNER MEWES , LANG CHRISTINE , VEEN MARKUS , SCHILLING MICHAEL , REINDL ANDREAS
Abstract: Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth of Streptococcus salivarius but does not stimulate the growth of Streptococcus mutans and/or Porphyromonas gingivalis. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.
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Patent Agency Ranking
公开(公告)号：AU2009256978A1
公开(公告)日：2009-12-17
申请号：AU2009256978
申请日：2009-05-19
Applicant: BASF SE
Inventor： BOTTNER MEWES , VEEN MARKUS , SCHILLING MICHAEL , REINDL ANDREAS , LANG CHRISTINE
Abstract: Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth of Streptococcus salivarius but does not stimulate the growth of Streptococcus mutans and/or Porphyromonas gingivalis. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.
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公开(公告)号：BRPI0914726A2
公开(公告)日：2015-10-20
申请号：BRPI0914726
申请日：2009-05-19
Applicant: BASF SE
Inventor： REINDL ANDREAS , LANG CHRISTINE , VEEN MARKUS , BÖTTNER MEWES , SCHILLING MICHAEL
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公开(公告)号：ZA200904963B
公开(公告)日：2010-09-29
申请号：ZA200904963
申请日：2009-07-16
Applicant: BASF SE
Inventor： REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
IPC: A23L29/00 , A23L33/00 , C12N20060101
Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
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公开(公告)号：AU2009256978B2
公开(公告)日：2015-07-30
申请号：AU2009256978
申请日：2009-05-19
Applicant: BASF SE
Inventor： LANG CHRISTINE , REINDL ANDREAS , BOTTNER MEWES , VEEN MARKUS , SCHILLING MICHAEL
Abstract: Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth of Streptococcus salivarius but does not stimulate the growth of Streptococcus mutans and/or Porphyromonas gingivalis. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.
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公开(公告)号：AU2006291480A1
公开(公告)日：2007-03-22
申请号：AU2006291480
申请日：2006-09-13
Applicant: BASF SE
Inventor： BUDDE ECKHARD , BOTTNER MEWES , REINDL ANDREAS , KNOLL ROLF , VEEN MARKUS , LANG CHRISTINE
Abstract: Described are microorganisms which are able to suppress the production of malodorous compounds by axillary bacteria. Also described are compositions comprising such microorganisms as well as the use of such micoorganisms in cosmetic, prophylactic or therapeutic applications.
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