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1.发明专利Use and method for preventing and/or treating caries caused by mutants streptococci 有权用于预防和/或治疗由MUTANTS STREPTOCOCCI引起的病症的用途和方法
公开(公告)号：JP2013151534A
公开(公告)日：2013-08-08
申请号：JP2013056953
申请日：2013-03-19
Applicant: Basf Se , ビーエーエスエフ ソシエタス・ヨーロピアBasf Se
Inventor： REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
CPC classification number: C12N1/20 , A23G3/366 , A23G4/123 , A23L33/135 , A61K8/99 , A61K35/747 , A61Q11/00 , C12R1/225
Abstract: PROBLEM TO BE SOLVED: To provide a means and method useful for preventing and/treating caries caused by bacteria other than Streptococcus mutans.SOLUTION: In the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, the microorganism capable of specifically binding to Streptococcus sobrinus, a microorganism belonging to the group of Lactobacillus or a mutant or derivative thereof is used for preparing an anticariogenic composition for the treatment or prevention of caries caused by the Streptococcus sobrinus.
Abstract translation: 要解决的问题：提供用于预防和/或治疗由变形链球菌以外的细菌引起的龋齿的方法和方法。解决方案：在使用属于乳酸菌或其突变体或衍生物的微生物中， 能够特异性结合链球菌（Streptococcus sobrinus）的微生物，属于乳杆菌属的微生物或其突变体或衍生物的微生物用于制备用于治疗或预防由链球菌引起的龋齿的抗焦虑性组合物。
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2.发明申请USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI 审中-公开用于预防和/或治疗由MUTANTS STREPTOCOCCI引起的药物的用途和方法
公开(公告)号：WO2008074473A2
公开(公告)日：2008-06-26
申请号：PCT/EP2007011127
申请日：2007-12-18
Applicant: BASF SE , REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
Inventor： REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
CPC classification number: C12N1/20 , A23G3/366 , A23G4/123 , A23L33/135 , A61K8/99 , A61K35/747 , A61Q11/00 , C12R1/225
Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
Abstract translation: 本发明涉及属于乳酸菌群或其突变体或衍生物的微生物的用途，其特征在于能够特异性结合属于变形链球菌链球菌属的细菌，其中特异性结合是 （i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成，用于制备用于治疗或预防由变形链球菌变异链球菌变异链球菌引起的龋齿的抗焦虑性组合物。 优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变种链球菌属组的细菌混合; （c）在允许形成所述微生物的聚集体和变种链球菌组的细菌的条件下温育步骤（b）中获得的混合物; 和（d）通过颗粒的发生检测聚集体。 本发明的另一方面是预防或治疗由变形链球菌变形链球菌以外的变形链球菌引起的龋齿的方法，包括给予属于所述乳酸菌群的微生物，其特征在于，所述微生物能够特异性结合属于 变体链球菌或所述微生物的突变体，衍生物，类似物或片段。
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公开(公告)号：ES2417132T3
公开(公告)日：2013-08-06
申请号：ES07866245
申请日：2007-12-18
Applicant: BASF SE
Inventor： REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
Abstract: Uso de un microorganismo perteneciente al genero Lactobacillus o un mutante o derivado del mismo, caracterizado porque es capaz de unirse especificamente a una bacteria perteneciente al grupo de mutans Streptococci, en donde la union especifica es (i) resistente al tratamiento por calor, en donde dicho tratamiento por calor se lleva a cabo a una temperatura de mas de 95°C durante al menos 20 minutos; y (ii) resistente al tratamiento con proteasa, en donde dicho tratamiento con proteasa es un tratamiento con una proteasa seleccionada del grupo consistente de pronasa E, proteinasa K , tripsina y quimiotripsina; y (iii) dependiente del calcio; y (iv) formado dentro de un rango de pH entre 4.5 y 8.5; y (v) formado en la presencia de saliva, para la preparacion de una composicion anticariogenica para el tratamiento o prevencion de caries causada por Streptococcus sobrinus uniendose a dicho Streptococcus sobrinus, en donde dicho derivado del microorganismo es una forma inactiva de dicho microorganismo o un fragmento de dicho microorganismo, siendo inactivado dicho microorganismo termicamente o liofilizado, en donde dicho fragmento es una fraccion de membrana obtenida mediante la preparacion de una membrana y en donde dicha forma inactivada o dicho fragmento retiene la capacidad de unirse especificamente a una bacteria perteneciente al grupo de mutans Streptococci.
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公开(公告)号：DE602004022857D1
公开(公告)日：2009-10-08
申请号：DE602004022857
申请日：2004-11-30
Applicant: BASF SE
Inventor： EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC , LEIN WOLFGANG , BOERNKE FREDERIK
Abstract: The present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase which, when absent, brings about retarded growth and chlorotic leaves, as target for herbicides. In this context, there are provided novel nucleic acid sequences comprising SEQ ID NO:5 and SEQ ID NO:7 and corresponding functional equivalents. Moreover, the present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase and its functional equivalents in a method for identifying herbicidal or growth-regulatory compounds, and to the use of the compounds identifed via the method as herbicides or growth regulators.
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公开(公告)号：AU2007334850A1
公开(公告)日：2008-06-26
申请号：AU2007334850
申请日：2007-12-18
Applicant: BASF SE
Inventor： BOTTNER MEWES , REINDL ANDREAS , VEEN MARKUS , LANG CHRISTINE
Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
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Patent Agency Ranking
公开(公告)号：ES2574135T3
公开(公告)日：2016-06-15
申请号：ES09761379
申请日：2009-05-19
Applicant: BASF SE
Inventor： BÖTTNER MEWES , LANG CHRISTINE , VEEN MARKUS , SCHILLING MICHAEL , REINDL ANDREAS
Abstract: Forma inactiva de un microorganismo perteneciente al género Lactobacillus, seleccionándose el microorganismo del grupo que consiste en microorganismos que tienen el número de registro de DSMZ DSM 19825, DSM 19826 o DSM 19827, caracterizada porque la forma inactivada significa una célula muerta o inactivada que ya no puede formar una colonia individual sobre una placa específica para microorganismos pertenecientes al género de Lactobacillus en la que dicha célula muerta o inactivada tiene una membrana celular o bien intacta o bien rota y el microorganismo muestra la siguiente propiedad (b) cuando se somete al siguiente ensayo (a): Ensayo (a): (a) se cultiva el microorganismo durante 24 h a 37ºC en condiciones anaerobias en un medio sintético que contiene péptidos 15 g/l con una densidad celular inicial de 1x107 10 células/ml, en la que el medio sintético tiene la siguiente composición: guanina: 0,1 g/l citosina: 0,1 g/l timidina: 0,1 g/l 2'-desoxiadenosina: 0,1 g/l 2'-desoxiuridina: 0,1 g/l K2HPO4: 2 g/l acetato de sodio: 5 g/l MgSO4 heptahidratado: 0,1 g/l hidrogenocitrato de diamonio: 2 g/l CaCl2 dihidratado: 0,5 g/l ácido oleico: 0,1% (p/v) cianocobalamina: 0,02 mg/l riboflavina: 10 mg/l ácido fólico: 0,2 mg/l 5-fosfato de piridoxal monohidratado: 10 mg/l ácido 4-aminobenzoico: 0,2 mg/l D-(+)-biotina: 1 mg/l ácido ascórbico: 500 mg/l ácido nicotínico: 10 mg/l pantotenato de Ca: 10 mg/l tiamina: 1 mg/l nitrato de cobalto (II) hexahidratado: 500 mg/l MnSO4 monohidratado: 20 mg/l MgSO4 heptahidratado: 500 mg/l Na2MoO4: 0,04 mg/l extracto de PTU: 15 g/l o 7 g/l D-glucosa monohidratada: 10 g/l; (b) se retiran las células mediante centrifugación a 4000 x g durante 15 min; y (c) se determina la concentración de péptidos en el sobrenadante resultante; propiedad (b): el microorganismo conduce a una reducción de la concentración de péptidos en el medio de cultivo de modo que la concentración de péptidos en el sobrenadante tras la incubación durante 24 h se reduce en al menos el 20% en comparación con la concentración inicial de 15 g/l, es decir el microorganismo puede reducir la concentración de péptidos en el medio en el ensayo (a) en al menos el 20%, en la que la forma inactiva muestra la propiedad de reducción en al menos el 20% de la concentración de péptidos de un medio sintético que contiene péptidos 7 g/l cuando se añade a dicho medio y se incuba durante 5 min a 37ºC en condiciones aerobias.
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公开(公告)号：BRPI0719279A2
公开(公告)日：2014-03-11
申请号：BRPI0719279
申请日：2007-12-18
Applicant: BASF SE
Inventor： REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
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公开(公告)号：AU2007334850B2
公开(公告)日：2012-06-14
申请号：AU2007334850
申请日：2007-12-18
Applicant: BASF SE
Inventor： BOTTNER MEWES , REINDL ANDREAS , VEEN MARKUS , LANG CHRISTINE
Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
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公开(公告)号：AT440947T
公开(公告)日：2009-09-15
申请号：AT04798124
申请日：2004-11-30
Applicant: BASF SE
Inventor： EHRHARDT THOMAS , REINDL ANDREAS , FREUND ANNETTE , SCHMIDT RALF-MICHAEL , SONNEWALD UWE , STITT NIGEL MARC , LEIN WOLFGANG , BIRNKE FREDERIK
Abstract: The present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase which, when absent, brings about retarded growth and chlorotic leaves, as target for herbicides. In this context, there are provided novel nucleic acid sequences comprising SEQ ID NO:5 and SEQ ID NO:7 and corresponding functional equivalents. Moreover, the present invention relates to the use of 2-methyl-6-solanylbenzoquinone methyltransferase and its functional equivalents in a method for identifying herbicidal or growth-regulatory compounds, and to the use of the compounds identifed via the method as herbicides or growth regulators.
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公开(公告)号：CA2671507A1
公开(公告)日：2008-06-26
申请号：CA2671507
申请日：2007-12-18
Applicant: BASF SE
Inventor： VEEN MARKUS , BOTTNER MEWES , REINDL ANDREAS , LANG CHRISTINE
Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, charact erized in that it is capable of specifically binding to a bacterium belongin g to the group of mutans Streptococci, wherein the specific binding is (i) r esistant to heat treatment; and/or (ii) resistant to protease treatment; and /or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4. 5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries c aused by mutans Streptococci other than Streptococcus mutans. Preferably, th e specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belongi ng to the group of mutans Streptococci which has been grown to stationary ph ase; (c) incubating the mixture obtained in step (b) under conditions allowi ng the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophyl axis or treatment of caries caused by mutans Streptococci other than Strepto coccus mutans, comprising administering a microorganism belonging to the gro up of lactic acid bacteria characterized in that said microorganism is capab le of specifically binding to a bacterium belonging to the group of mutans S treptococci or a mutant, derivative, analog or fragment of said microorganis m.
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