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    USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI
    4.
    发明申请
    USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI 审中-公开
    用于预防和/或治疗由MUTANTS STREPTOCOCCI引起的药物的用途和方法

    公开(公告)号：WO2008074473A2

    公开(公告)日：2008-06-26

    申请号：PCT/EP2007011127

    申请日：2007-12-18

    Applicant: BASF SE ,  REINDL ANDREAS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  VEEN MARKUS

    Inventor： REINDL ANDREAS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  VEEN MARKUS

    IPC: A61K35/74 ,  A61P1/02

    CPC classification number: C12N1/20 ,  A23G3/366 ,  A23G4/123 ,  A23L33/135 ,  A61K8/99 ,  A61K35/747 ,  A61Q11/00 ,  C12R1/225

    Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.

    Abstract translation: 本发明涉及属于乳酸菌群或其突变体或衍生物的微生物的用途，其特征在于能够特异性结合属于变形链球菌链球菌属的细菌，其中特异性结合是 （i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成，用于制备用于治疗或预防由变形链球菌变异链球菌变异链球菌引起的龋齿的抗焦虑性组合物。 优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变种链球菌属组的细菌混合; （c）在允许形成所述微生物的聚集体和变种链球菌组的细菌的条件下温育步骤（b）中获得的混合物; 和（d）通过颗粒的发生检测聚集体。 本发明的另一方面是预防或治疗由变形链球菌变形链球菌以外的变形链球菌引起的龋齿的方法，包括给予属于所述乳酸菌群的微生物，其特征在于，所述微生物能够特异性结合属于 变体链球菌或所述微生物的突变体，衍生物，类似物或片段。

    USE AND METHODS FOR PREVENTING AND/OR TREATING ORAL MALODOUR
    6.
    发明专利
    USE AND METHODS FOR PREVENTING AND/OR TREATING ORAL MALODOUR 未知

    公开(公告)号：CA2724769A1

    公开(公告)日：2009-12-17

    申请号：CA2724769

    申请日：2009-05-19

    Applicant: BASF SE

    Inventor： BOETTNER MEWES ,  LANG CHRISTINE ,  VEEN MARKUS ,  SCHILLING MICHAEL ,  REINDL ANDREAS

    IPC: C12N1/20 ,  A61K8/99 ,  A61K35/74

    Abstract: Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth of Streptococcus salivarius but does not stimulate the growth of Streptococcus mutans and/or Porphyromonas gingivalis. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.

    Usos y métodos para prevenir y/o tratar caries causadas por mutans Streptococci
    7.
    发明专利
    Usos y métodos para prevenir y/o tratar caries causadas por mutans Streptococci 未知

    公开(公告)号：ES2417132T3

    公开(公告)日：2013-08-06

    申请号：ES07866245

    申请日：2007-12-18

    Applicant: BASF SE

    Inventor： REINDL ANDREAS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  VEEN MARKUS

    IPC: C12N1/20 ,  A23L29/00 ,  A23L33/00 ,  A61K35/74

    Abstract: Uso de un microorganismo perteneciente al genero Lactobacillus o un mutante o derivado del mismo, caracterizado porque es capaz de unirse especificamente a una bacteria perteneciente al grupo de mutans Streptococci, en donde la union especifica es (i) resistente al tratamiento por calor, en donde dicho tratamiento por calor se lleva a cabo a una temperatura de mas de 95°C durante al menos 20 minutos; y (ii) resistente al tratamiento con proteasa, en donde dicho tratamiento con proteasa es un tratamiento con una proteasa seleccionada del grupo consistente de pronasa E, proteinasa K , tripsina y quimiotripsina; y (iii) dependiente del calcio; y (iv) formado dentro de un rango de pH entre 4.5 y 8.5; y (v) formado en la presencia de saliva, para la preparacion de una composicion anticariogenica para el tratamiento o prevencion de caries causada por Streptococcus sobrinus uniendose a dicho Streptococcus sobrinus, en donde dicho derivado del microorganismo es una forma inactiva de dicho microorganismo o un fragmento de dicho microorganismo, siendo inactivado dicho microorganismo termicamente o liofilizado, en donde dicho fragmento es una fraccion de membrana obtenida mediante la preparacion de una membrana y en donde dicha forma inactivada o dicho fragmento retiene la capacidad de unirse especificamente a una bacteria perteneciente al grupo de mutans Streptococci.

    8.
    发明专利
    未知

    公开(公告)号：AT465239T

    公开(公告)日：2010-05-15

    申请号：AT05790013

    申请日：2005-09-09

    Applicant: BASF SE

    Inventor： KAESLER BRUNO ,  KNOELL ROLF ,  BOETTNER MEWES ,  BUDDE ECKHARD ,  LANG CHRISTINE ,  RYSER MARTIN ,  VEEN MARKUS

    IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

    Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

    Uses and methods for preventing and/or treating caries caused by mutants Streptococci
    9.
    发明专利
    Uses and methods for preventing and/or treating caries caused by mutants Streptococci 未知

    公开(公告)号：ZA200904963B

    公开(公告)日：2010-09-29

    申请号：ZA200904963

    申请日：2009-07-16

    Applicant: BASF SE

    Inventor： REINDL ANDREAS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  VEEN MARKUS

    IPC: A23L29/00 ,  A23L33/00 ,  C12N20060101

    Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.

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