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公开(公告)号：DE69632012T2
公开(公告)日：2004-12-30
申请号：DE69632012
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I
IPC: A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D17/038 , B01D17/12 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Blood processing systems and methods convey whole blood from a donor into a centrifugal separation device for separation into red blood cells and a plasma constituent. The plasma constituent and red blood cells are removed from the separation device at least in part while whole blood is conveyed into the separation device. The systems and methods generate, at least in part while whole blood is conveyed into the separation device and plasma constituent and red blood cells are removed from the separation device, a control command affecting separation within the separation device based, at least in part, upon a factor representing hematocrit of red blood cells separated in the separation device.
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公开(公告)号：DE69631282D1
公开(公告)日：2004-02-12
申请号：DE69631282
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I
IPC: A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D17/038 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Blood collection systems and methods minimize citrate toxicity in donors. The systems and methods convey whole blood at a prescribed rate Qb into a separation device for separation into red blood cells and a plasma constituent. The systems and methods add anticoagulant including citrate to the whole blood. The systems and methods control Qb (in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQBCIR, where: where: CIR is a selected nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), AC is a selected anticoagulant ratio, Wgt is the donor's weight (in kg or equivalent), and CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent).
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公开(公告)号：DE69623234T2
公开(公告)日：2003-04-30
申请号：DE69623234
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I
IPC: A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B1/00 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Systems and methods predict a whole blood processing volume required to achieve a desired platelet yield based upon inputs of selected processing parameters.
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公开(公告)号：DE69626832D1
公开(公告)日：2003-04-24
申请号：DE69626832
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I , MIN KYUNGYOON
IPC: A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: A blood separation system for separating mono nuclear cells from whole blood is described. The system comprises a chamber (12) that is rotatable about a rotational axis (28). The chamber comprises first and second spaced apart walls (24, 26) that form a separation zone having a high-G side and a low-G side which is located closer to the rotational axis than the high-G side. The chamber also includes an inlet region (74) where whole blood enters the separation zone for separation into red blood cells (96), a plasma constituent carrying platelets (98), and an interface (58) carrying mono nuclear cells between the red blood cells and the plasma constituent. A plasma constituent collection region (76) is also provided in the chamber where the plasma constituent is collected for removal from the chamber. An outlet path (46, 206) communicates with the plasma constituent collection region (76) and provides for removal of the interface (58) from the chamber. The system is operated under the control of a controller (134) that is operable in first and second modes. In the first mode, whole blood is conveyed into the inlet region while red blood cells and the plasma constituent are removed from the chamber and while the interface (58) is maintained at a set location within the chamber. In the second mode, the controller operates to move the interface from the set location for removal from the chamber via the outlet path. Finally, the system is equipped with a sensing element (226) for detecting mono nuclear cells in the interface in the outlet path. A method of separating mono nuclear cells from whole blood is also described.
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Patent Agency Ranking
公开(公告)号：DE69424522T2
公开(公告)日：2001-02-08
申请号：DE69424522
申请日：1994-02-14
Applicant: BAXTER INT
Inventor： BROWN I
Abstract: Systems and methods resuspend cellular-rich concentrates of blood by rocking the separation chamber to create variable agitation forces within the separation chamber. The systems and methods also add resuspension fluids to aid the resuspension.
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公开(公告)号：DE3876886T2
公开(公告)日：1993-04-29
申请号：DE3876886
申请日：1988-01-29
Applicant: BAXTER INT
Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.
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公开(公告)号：DE3876886D1
公开(公告)日：1993-02-04
申请号：DE3876886
申请日：1988-01-29
Applicant: BAXTER INT
Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus includes a dual member centrifuge and an associated fluid flow transfer set. The transfer set has a collection container in which a quantity of fluid can be initially accumulated. The collection container is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container in the dual member centrifuge thereby separating out the selected fluid component. The component can then be pumped out of the collection container into the component accumulation container. The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.
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公开(公告)号：DE69632012D1
公开(公告)日：2004-05-06
申请号：DE69632012
申请日：1996-05-22
Applicant: BAXTER INT
Inventor： BROWN I
IPC: A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D17/038 , B01D17/12 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
Abstract: Blood processing systems and methods convey whole blood from a donor into a centrifugal separation device for separation into red blood cells and a plasma constituent. The plasma constituent and red blood cells are removed from the separation device at least in part while whole blood is conveyed into the separation device. The systems and methods generate, at least in part while whole blood is conveyed into the separation device and plasma constituent and red blood cells are removed from the separation device, a control command affecting separation within the separation device based, at least in part, upon a factor representing hematocrit of red blood cells separated in the separation device.
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公开(公告)号：DE69431653D1
公开(公告)日：2002-12-12
申请号：DE69431653
申请日：1994-03-17
Applicant: BAXTER INT
Inventor： BROWN I , WILLIAMSON P , DIPERNA PAUL
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