公开(公告)号：BR9106205A

公开(公告)日：1993-03-30

申请号：BR9106205

申请日：1991-10-10

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  JOHNSON ROBERT C ,  MARTINSON LAURA A ,  HILL RONALD S

IPC: A61B5/00 ,  A61F20060101 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61F2/00

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

公开(公告)号：NO922566L

公开(公告)日：1992-06-29

申请号：NO922566

申请日：1992-06-29

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  JOHNSON ROBERT C ,  MARTINSON LAURA A ,  HILL RONALD S

IPC: A61B5/00 ,  A61F20060101 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61F2/00

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

公开(公告)号：ES2090364T3

公开(公告)日：1996-10-16

申请号：ES91920717

申请日：1991-10-10

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  JOHNSON ROBERT C ,  MARTINSON LAURA A ,  HILL RONALD S

IPC: A61B5/00 ,  A61F20060101 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61F2/00

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

公开(公告)号：AT138256T

公开(公告)日：1996-06-15

申请号：AT91920717

申请日：1991-10-10

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  JOHNSON ROBERT C ,  MARTINSON LAURA A ,  HILL RONALD S

IPC: A61B5/00 ,  A61F20060101 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61F2/00

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

公开(公告)号：CA2148354A1

公开(公告)日：1995-03-30

申请号：CA2148354

申请日：1994-09-20

Applicant: BAXTER INT

Inventor： MARTINSON LAURA A ,  BRAUKER JAMES H ,  JOHNSON ROBERT C ,  LOUDOVARIS THOMAS

IPC: A61K9/00 ,  A61K35/12 ,  A61K38/00 ,  A61K38/13 ,  A61L27/38 ,  A61P37/06 ,  B65D5/42 ,  A61L27/00 ,  A61M37/00

Abstract: 2148354 9508355 PCTABS00036 Methods for enhancing vascular support of cells housed within an implanted apparatus are disclosed. The methods comprise placing a population of therapeutic substance-producing cells into the cell receiving chamber of an immunoisolation apparatus, implanting the apparatus into a patient, and administering an immunomodulatory agent to the patient. The immunomodulatory agent increases the number of close vascular structures in the vicinity of the implanted device, which increases the long term survival of the cell population housed therein.

公开(公告)号：NO922566D0

公开(公告)日：1992-06-29

申请号：NO922566

申请日：1992-06-29

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  JOHNSON ROBERT C ,  MARTINSON LAURA A ,  HILL RONALD S

IPC: A61B5/00 ,  A61F20060101 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61F

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

公开(公告)号：FI923023A0

公开(公告)日：1992-06-29

申请号：FI923023

申请日：1992-06-29

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  JOHNSON ROBERT C ,  MARTINSON LAURA A ,  HILL RONALD S

IPC: A61B5/00 ,  A61F20060101 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61F

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

公开(公告)号：AU8951491A

公开(公告)日：1992-05-26

申请号：AU8951491

申请日：1991-10-10

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  JOHNSON ROBERT C ,  MARTINSON LAURA A ,  HILL RONALD S

IPC: A61B5/00 ,  A61F20060101 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14 ,  A61F2/00

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

公开(公告)号：DK0676935T3

公开(公告)日：2001-12-27

申请号：DK93908495

申请日：1993-03-25

Applicant: BAXTER INT

Inventor： JOHNSON ROBERT C ,  BRAUKER JAMES H ,  HILL RONALD S ,  MARTINSON LAURA A ,  JOHNSTON WILLIAM D

IPC: A61F2/02 ,  A61K9/00 ,  A61L27/38 ,  A61L27/00 ,  C12N5/00

Abstract: Implant assemblies (10) and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved boundary between the host and the implanted cells (12). The boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells (12) during the critical ischemic period and afterward. The boundary allows the fabrication and clinical use of implant assemblies and methodologies that can carry enough cells (12) to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.

公开(公告)号：AT195852T

公开(公告)日：2000-09-15

申请号：AT93908494

申请日：1993-03-25

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  HILL RONALD S ,  MARTINSON LAURA A ,  BOGGS DANIEL R ,  JOHNSON ROBERT C

IPC: A61B5/00 ,  A61F2/02 ,  A61F2/06 ,  A61K9/00 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/14 ,  C08K3/30

Abstract: A method for implanting cells is disclosed which employs a chamber having a wall forming porous boundary between the host and implanted cells. According to the method, a given number of cells (N) is placed within the porous boundary of a given area (A) such that the quantity A/N is less than about 200 mu m2/cell. The porous boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward.