公开(公告)号：WO2006021314A8

公开(公告)日：2006-05-18

申请号：PCT/EP2005008467

申请日：2005-08-04

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  ANDERLE HEINZ ,  MATTHIESSEN PETER ,  SCHWARZ HANS-PETER ,  TURECEK PETER ,  KREIL THOMAS ,  BOGGS DANIEL R

Inventor： ANDERLE HEINZ ,  MATTHIESSEN PETER ,  SCHWARZ HANS-PETER ,  TURECEK PETER ,  KREIL THOMAS ,  BOGGS DANIEL R

IPC: A61L2/10 ,  A61L2/28 ,  C02F1/32 ,  G01J1/00 ,  G01N23/00 ,  G01T1/00

CPC classification number: A61L2/10 ,  A23L3/26 ,  A23L3/28 ,  A61L2/0011 ,  A61L2/28 ,  G01N21/33 ,  H05B3/0052

Abstract: The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivete microorganisms present in a biological fluid, preferably a non-trannsparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.

Abstract translation: 本发明涉及一种用于确定来自一种或多种光源的单色或多色光的有效剂量以使存在于生物流体，优选非透明流体中的微生物灭活的方法。 此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。 此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。 本发明还提供一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭活间歇反应器中存在于生物流体中的微生物。

公开(公告)号：WO2006021314A2

公开(公告)日：2006-03-02

申请号：PCT/EP2005008467

申请日：2005-08-04

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  ANDERLE HEINZ ,  MATTHIESSEN PETER ,  SCHWARZ HANS-PETER ,  TURECEK PETER ,  KREIL THOMAS ,  BOGGS DANIEL R

Inventor： ANDERLE HEINZ ,  MATTHIESSEN PETER ,  SCHWARZ HANS-PETER ,  TURECEK PETER ,  KREIL THOMAS ,  BOGGS DANIEL R

IPC: A61L2/10 ,  A61L2/28 ,  C02F1/32 ,  G01J1/00 ,  G01N23/00 ,  G01T1/00

CPC classification number: A61L2/10 ,  A23L3/26 ,  A23L3/28 ,  A61L2/0011 ,  A61L2/28 ,  G01N21/33 ,  H05B3/0052

Abstract: The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivete microorganisms present in a biological fluid, preferably a non-trannsparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.

公开(公告)号：WO2004075931A3

公开(公告)日：2004-12-23

申请号：PCT/EP2004001994

申请日：2004-02-27

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  ANDERLE HEINZ ,  MATTHIESSEN PETER ,  SCHWARZ HANS-PETER ,  TURECEK PETER ,  KREIL THOMAS ,  BOGGS DANIEL R

Inventor： ANDERLE HEINZ ,  MATTHIESSEN PETER ,  SCHWARZ HANS-PETER ,  TURECEK PETER ,  KREIL THOMAS ,  BOGGS DANIEL R

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61L2/28 ,  G01J1/00 ,  G01J1/08 ,  G01J1/42 ,  G01J1/48 ,  G01N21/00

CPC classification number: G01J1/08 ,  A61L2/0011 ,  A61L2/0017 ,  A61L2/0052 ,  A61L2/10 ,  A61L2/28 ,  A61L2202/22 ,  A61M1/3681 ,  A61M1/3683 ,  A61M2205/053 ,  C02F1/32 ,  C02F2201/326 ,  G01J1/42 ,  G01J1/48

Abstract: A validatable method for determining a photochemically effective dose for inactivating pathogens in a fluid sample is described herein. In particular, the instant invention covers methods for determining a photochemically effective doses sufficient to inactivate pathogens in a biological sample while leaving biologically active substances of interest unaffected. A batch irradiation reactor effective for inactivating pathogens in biological samples is also described.

Abstract translation: 本文描述了用于确定用于灭活流体样品中病原体的光化学有效剂量的可验证方法。 特别地，本发明包括确定足以灭活生物样品中的病原体的光化学有效剂量同时使感兴趣的生物活性物质不受影响的方法。 还描述了有效用于灭活生物样品中的病原体的批量照射反应器。

公开(公告)号：WO0002638A9

公开(公告)日：2000-04-06

申请号：PCT/US9914471

申请日：1999-06-25

Applicant: BAXTER INT

Inventor： BOGGS DANIEL R ,  STERNBERG SHMUEL ,  PAULEY ROBIN G ,  MCLARTY DONNA L

IPC: B01D69/12 ,  A61M1/36 ,  B01D69/14 ,  B01D71/20 ,  B01D71/30 ,  B01D71/38 ,  B01D71/54 ,  B01J20/28 ,  B01D24/00 ,  B01D29/00 ,  B05D5/00

CPC classification number: B01J20/28033 ,  A61M1/3686 ,  B01D69/141 ,  B01J20/28004 ,  B01J20/28026 ,  B01J20/28035

Abstract: Membranes and methods for making membranes are disclosed. The membranes (10) include a polymeric matrix (16) and a particulate material immobilized within the matrix. The membrane may further include a skin layer (19) having randomly spaced surface pores (21). The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.

Abstract translation: 披露了制造膜的膜和方法。 膜（10）包括聚合物基质（16）和固定在基质内的颗粒材料。 膜还可以包括具有随机间隔的表面孔（21）的表层（19）。 作为病原体灭活处理的一部分，膜可以特别用于从生物流体中去除有机化合物的方法和设备中。

公开(公告)号：EP1094876A4

公开(公告)日：2003-02-05

申请号：EP99931933

申请日：1999-06-25

Applicant: BAXTER INT

Inventor： BOGGS DANIEL R ,  STERNBERG SHMUEL ,  PAULEY ROBIN G ,  MCLARTY DONNA L

IPC: B01D69/12 ,  A61M1/36 ,  B01D69/14 ,  B01D71/20 ,  B01D71/30 ,  B01D71/38 ,  B01D71/54 ,  B01J20/28 ,  B01D24/00 ,  B01D29/00 ,  B05D5/00 ,  C08J5/22

CPC classification number: B01J20/28033 ,  A61M1/3686 ,  B01D69/141 ,  B01J20/28004 ,  B01J20/28026 ,  B01J20/28035

Abstract: Membranes and methods for making membranes are disclosed. The membranes (10) include a polymeric matrix (16) and a particulate material immobilized within the matrix. The membrane may further include a skin layer (19) having randomly spaced surface pores (21). The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.

公开(公告)号：EP0633755A4

公开(公告)日：1995-08-30

申请号：EP93908494

申请日：1993-03-25

Applicant: BAXTER INT

Inventor： BRAUKER JAMES H ,  HILL RONALD S ,  MARTINSON LAURA A ,  BOGGS DANIEL R ,  JOHNSON ROBERT C

IPC: A61B5/00 ,  A61F2/02 ,  A61F2/06 ,  A61K9/00 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/14 ,  C08K3/30

CPC classification number: A61K9/0024 ,  A61B5/14532 ,  A61F2/022 ,  A61L27/38 ,  A61L27/56 ,  A61L29/005 ,  A61L29/146

公开(公告)号：EP1094883A4

公开(公告)日：2003-03-19

申请号：EP99931936

申请日：1999-06-25

Applicant: BAXTER INT ,  CERUS CORP

Inventor： BOGGS DANIEL R ,  HEI DEREK J ,  STERNBERG SCHMUEL ,  PAULEY ROBIN G ,  MCLARTY DONNA L

IPC: B01D61/00 ,  A61M1/36 ,  B01D15/00 ,  B01D69/00 ,  B01D71/02 ,  B01D71/16 ,  B01D71/30 ,  B01D71/54 ,  B01J20/28

CPC classification number: B01D69/148 ,  A61M1/02 ,  A61M1/3686 ,  B01D63/087 ,  B01D63/14 ,  B01D65/022 ,  B01D67/0009 ,  B01D67/0086 ,  B01D69/02 ,  B01D69/10 ,  B01D69/147 ,  B01D71/16 ,  B01D71/30 ,  B01D71/34 ,  B01D71/54 ,  B01D2321/346 ,  B01D2323/42 ,  B01D2325/38

Abstract: A membrane (10) and a method for making a membrane (10) are disclosed. The membrane (10) includes a polymeric matrix (16) and a particulate material immobilized within the matrix (16). The membrane (10) may include a support (18) within the core of the mebrane (10) and may further include a skin (19). The membrane (10) may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.

公开(公告)号：EP0303684A4

公开(公告)日：1989-10-11

申请号：EP88902720

申请日：1988-02-26

Applicant: BAXTER INT

Inventor： JOHNSON RICHARD I ,  CHENOWETH DENNIS E ,  BOGGS DANIEL R ,  LYSAGHT MICHAEL J

IPC: A61M1/18 ,  A61M1/36 ,  B01D67/00 ,  B01D69/08 ,  B01D71/10 ,  B01D71/82 ,  D01D5/24 ,  D01F2/04 ,  D01F2/28 ,  B01D13/00

CPC classification number: B01D67/0093 ,  A61M1/3679 ,  A61M1/3687 ,  A61M2202/0421 ,  B01D69/08 ,  A61M2202/0057

Abstract: A material (16) is formed into hollow fiber form, and the surface characteristics of the interior bore is selectively modified in a predetermined fashion by a reactive lumen fluid. Nucleophilic materials, such as regenerated cellulose, can be formed into hollow fibers and simultaneously modified to improve their biocompatibility in accordance with the invention.

Abstract translation: 材料（16）形成中空纤维形式，并且内腔的表面特性通过反应腔流体以预定方式选择性地改变。 根据本发明，亲核材料如再生纤维素可以形成中空纤维并同时改性以改善其生物相容性。

公开(公告)号：CA2398241C

公开(公告)日：2009-03-31

申请号：CA2398241

申请日：2001-01-26

Applicant: BAXTER INT

Inventor： BREILLATT JULIAN ,  BOGGS DANIEL R ,  WOO LECON ,  KHARE ATUL ,  SANDFORD CRAIG ,  STERNBERG SHMUEL

IPC: A61L2/08 ,  A61L2/00 ,  A61L2/10 ,  A61M1/02 ,  A61M1/36

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outl et (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow , which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

公开(公告)号：AU2005276707A1

公开(公告)日：2006-03-02

申请号：AU2005276707

申请日：2005-08-04

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： BOGGS DANIEL R ,  TURECEK PETER ,  MATTHIESSEN PETER ,  ANDERLE HEINZ ,  SCHWARZ HANS-PETER ,  KREIL THOMAS

IPC: A61L2/10 ,  A61L2/28 ,  C02F1/32 ,  G01J1/00 ,  G01N23/00 ,  G01T1/00