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    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION
    14.
    发明公开
    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION 有权
    灭菌辐射治疗流感病毒失活的装置和方法

    公开(公告)号：EP1263480A1

    公开(公告)日：2002-12-11

    申请号：EP01905092.1

    申请日：2001-01-26

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： WOO, Lecon ,  BOGGS, Daniel, R. ,  STERNBERG, Shmuel ,  SANDFORD, Craig ,  KHARE, Atul ,  BREILLATT, Julian

    IPC: A61L2/10 ,  A61L2/02 ,  A61M1/36

    CPC classification number: A61L2/10 ,  A61L2/0011 ,  A61M1/0281 ,  A61M1/3681 ,  A61M2202/0415 ,  A61M2205/053

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

    Abstract translation: 一种装置和方法，用于以连续流动布置灭菌辐射灭活治疗流体中的病原体，同时表现出流体在装置内的辐射剂量均匀性和狭窄的停留时间分布。 装置（10）包括具有设置在其中的同心圆柱形转子（14）的辐射可透过圆柱形管（12），从而在其间提供薄间隙（16）。 具有流体出口（26）的顶板（18）和具有流体入口（24）的底板（20）密封圆柱形管（12）。 入口（24）和出口（26）均与薄间隙（16）流体连通。 转子轴（36）轴向穿过圆柱形转子（14）并与马达（30）连接。 泵提供通过装置（10）的流体流动。 辐射源通过圆柱形管（12）向流体提供消毒辐射。 当流体流动时，马达（30）驱动转子（14）以向流体流施加泰勒涡旋，这使流体更靠近圆柱形管（12），流体更接近转子（14）。

    MOBILE, SELF-CONTAINED BLOOD COLLECTION SYSTEM AND METHOD
    15.
    发明公开
    MOBILE, SELF-CONTAINED BLOOD COLLECTION SYSTEM AND METHOD 失效
    移动和独立的设备，采血及相应方法。

    公开(公告)号：EP0291519A1

    公开(公告)日：1988-11-23

    申请号：EP87907371.0

    申请日：1987-10-13

    Applicant: BAXTER INTERNATIONAL INC. (a Delaware corporation) ,  THE AMERICAN NATIONAL RED CROSS

    Inventor： LYSAGHT, Michael, J. ,  BOGGS, Daniel, R. ,  RITGER, Philip, L. ,  STROMBERG, Robert, R. ,  FRIEDMAN, Leonard, I

    IPC: A61M1 ,  A61M5

    CPC classification number: A61M5/1483 ,  A61M1/30 ,  A61M1/302 ,  A61M1/308 ,  A61M1/3643 ,  A61M1/3644 ,  A61M5/148 ,  A61M2205/8225

    Abstract: Procédés et systèmes de récupération des composants sanguins, tels que le plasma, à partir de donneurs (D). Un procédé consiste à récupérer une unité de sang entier à partir d'un donneur (D), à faire passer de force l'unité de sang récupérée au travers d'un séparateur de plasma (90), à accumuler le plasma dans un conteneur (94) et à retourner les cellules concentrées aux donneurs (D). Un système comprend un ensemble jetable de récupération du sang (14) et un appareillage réutilisable (12) dans lequel l'ensemble de récupération (14) peut être monté. L'appareillage (12) est actionné par une source d'énergie autonome ne nécessitant aucune connexion électrique ou autre source extérieure d'énergie.

    Abstract translation: 该装置是爱血液分离特别有用并且包括用于血液分离成成分和接收血液，分离器（90）的可变容积的容器（86）的力施加装置，用于通过分离器迫使血液从容器返回到供体 ， 该装置是自包含的，便携的，所述施力装置（34B，24,52）被保持由固定件（12），所以可释放支持分离器（90）和容器（86）。 所述力施加装置包括可再充电能量存储装置：例如用于保持压缩气体的可更换模块（c）所有其用于膨胀的囊（34b）的压缩的容器（86）。 电气和机械存储装置是替代描述。

    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION
    17.
    发明公开
    DEVICE AND METHOD FOR PATHOGEN INACTIVATION OF THERAPEUTIC FLUIDS WITH STERILIZING RADIATION 有权
    装置和方法对于治疗液的病原体灭活灭菌辐射

    公开(公告)号：EP1263481A1

    公开(公告)日：2002-12-11

    申请号：EP01912673.9

    申请日：2001-01-26

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： WOO, Lecon ,  BOGGS, Daniel, R. ,  STERNBERG, Shmuel ,  SANDFORD, Craig ,  KHARE, Atul ,  BREILLATT, Julian

    IPC: A61L2/10 ,  A61L2/02 ,  A61M1/36

    CPC classification number: A61M1/3681 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/0281 ,  A61M2202/0415 ,  A61M2205/053

    Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a 'carrying' mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

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