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    MULTIPLE LAYER, FORMED-IN-PLACE IMMUNOISOLATION MEMBRANE STRUCTURES FOR IMPLANTATION OF CELLS IN HOST TISSUE
    2.
    发明申请
    MULTIPLE LAYER, FORMED-IN-PLACE IMMUNOISOLATION MEMBRANE STRUCTURES FOR IMPLANTATION OF CELLS IN HOST TISSUE 审中-公开
    多层，形成的免疫组织膜结构，用于植入宿主细胞中的细胞

    公开(公告)号：WO1996036296A1

    公开(公告)日：1996-11-21

    申请号：PCT/US1996006826

    申请日：1996-05-13

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： BAXTER INTERNATIONAL INC. ,  PAULEY, Robin, G. ,  McLARTY, Donna, L. ,  KHARE, Atul, R. ,  STERNBERG, Shmuel ,  BOGGS, Daniel, R. ,  NEUENFELDT, Steven ,  JONES, Mark ,  BRAUKER, James, H. ,  MARTINSON, Laura, A.

    IPC: A61F02/02

    CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61L27/38

    Abstract: A permeable structure (16) forms a chamber (12) to hold living cells (14). The structure includes a first permeable region (18) surrounding at least a portion of the chamber (12) having a confirmation that, when implanted is host tissue, substantially blocks penetration of host cells into the chamber (12) while permitting solute transport. The structure (16) also includes a second permeable region (20) overlaying the first permeable region (18) having a confirmation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region (22) is located between the first (18) and second (20) permeable regions. The third region (22) comprises a solution of polymer material formed in place between the first (18) and second (20) permeable regions. The third permeable region (22) bonds the first (18) and second (20) permeable regions together. The third permeable region (22) also has a confirmation that, when implanted in host tissue, permits solute transport between the first (18) and second (20) permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first (18) and second (20) regions. The third, formed-in-place region (22) can also have a confirmation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane (22) is sufficient high that it does not adversely effect the permability value desired for the overall multiple layer structure (16).

    Abstract translation: 可渗透结构（16）形成容纳活细胞（14）的腔室（12）。 该结构包括围绕腔室（12）的至少一部分的第一可渗透区域（18），其确认当植入的是宿主组织时，基本上阻止宿主细胞渗入腔室（12），同时允许溶质运输。 结构（16）还包括覆盖第一可渗透区域（18）的第二可渗透区域（20），其确认当植入宿主组织时，与允许溶质运输的宿主组织形成可渗透界面。 第三可渗透区域（22）位于第一（18）和第二（20）可渗透区域之间。 第三区域（22）包括在第一（18）和第二（20）可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域（22）将第一（18）和第二（20）可渗透区域结合在一起。 第三渗透区域（22）还确认，当植入到宿主组织中时，允许第一（18）和第二（20）可渗透区域之间的溶质传输在一起，提供坚固的层压结构，其抵抗植入期间的分层，由 细胞浸润到第一（18）和第二（20）区域之间的不连续空间。 第三个就地区域（22）也可以具有提供免疫隔离效果的确认。 此外，第三就地形成膜（22）的渗透性足够高，使得其不会对整个多层结构（16）所期望的渗透性值产生不利影响。

    SYSTEMS AND METHODS FOR CELLS IMPLANTS
    3.
    发明申请
    SYSTEMS AND METHODS FOR CELLS IMPLANTS 审中-公开
    细胞植入物的系统和方法

    公开(公告)号：WO1993019700A1

    公开(公告)日：1993-10-14

    申请号：PCT/US1993002665

    申请日：1993-03-25

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： BAXTER INTERNATIONAL INC. ,  BRAUKER, James, H. ,  HILL, Ronald, S. ,  MARTINSON, Laura, A. ,  BOGGS, Daniel, R. ,  JOHNSON, Robert, C.

    IPC: A61F02/02

    CPC classification number: A61K9/0024 ,  A61B5/14532 ,  A61F2/022 ,  A61L27/38 ,  A61L27/56 ,  A61L29/005 ,  A61L29/146

    Abstract: Implant assemblies (10) and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved boundary (34) between the host and the implanted cells. The boundary (34) has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward. The boundary (34) allows the fabrication and clinical use of implant assemblies (10) and methodologies that can carry enough cells to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.

    Abstract translation: 植入组件（10）和方法为植入的同种异体移植物，异种移植物和同种移植物提供免疫保护。 组件和方法在主机和植入的细胞之间建立改进的边界（34）。 边界（34）具有孔隙尺寸，极限强度和代谢转运值，可确保临界缺血期及以后细胞的存活。 边界（34）允许植入组件（10）的制造和临床使用以及可以携带足够的细胞对宿主具有治疗价值的植入物组件（10）和方法，而占据主机内相对较小，紧凑的区域。

    POLYVINYLIDENE DIFLUORIDE MEMBRANES AND METHODS FOR MAKING SUCH MEMBRANES
    7.
    发明公开
    POLYVINYLIDENE DIFLUORIDE MEMBRANES AND METHODS FOR MAKING SUCH MEMBRANES 审中-公开
    聚亚乙烯二氟化物膜及制备这种膜的方法

    公开(公告)号：EP1140334A1

    公开(公告)日：2001-10-10

    申请号：EP00941430.1

    申请日：2000-06-15

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： STERNBERG, Shmuel ,  BOGGS, Daniel, R. ,  PAULEY, Robin, G. ,  MOY, Bonny

    IPC: B01D71/28

    CPC classification number: B01D67/0088 ,  B01D63/16 ,  B01D69/02 ,  B01D71/34

    Abstract: Microporous membranes (10) comprising polyvinylidene difluoride and methods for making such membranes are disclosed. The membranes (10), which are not crosslinked and are not contacted with a strong alkali solution during manufacture, are wettable by aqueous solution even after repeated wetting and drying. The membrane includes a support (18) and surfaces (11) treated with a hydrophilic coating. Separately, such membranes are also useful in apparatus (60) for separating a biological fluid into two or more components.

    Abstract translation: 公开了包含聚偏二氟乙烯的微孔膜（10）和用于制造这种膜的方法。 没有交联并且在制造过程中不与强碱溶液接触的膜（10）即使在反复润湿和干燥之后也可以通过水溶液润湿。 该膜包括支持物（18）和用亲水涂层处理过的表面（11）。 单独地，这种膜也可用于将生物流体分离成两种或更多种组分的设备（60）。

    BLOOD COLLECTION SYSTEM AND METHOD
    9.
    发明授权
    BLOOD COLLECTION SYSTEM AND METHOD 失效
    VORRICHTUNG ZUM SAMMELN VON BLUT SOWIE ENTSPRECHENDES VERFAHREN。

    公开(公告)号：EP0291519B1

    公开(公告)日：1995-08-02

    申请号：EP87907371.6

    申请日：1987-10-13

    Applicant: BAXTER INTERNATIONAL INC. (a Delaware corporation) ,  THE AMERICAN NATIONAL RED CROSS

    Inventor： LYSAGHT, Michael, J. ,  BOGGS, Daniel, R. ,  RITGER, Philip, L. ,  STROMBERG, Robert, R. ,  FRIEDMAN, Leonard, I

    IPC: A61M1/00

    CPC classification number: A61M5/1483 ,  A61M1/30 ,  A61M1/302 ,  A61M1/308 ,  A61M1/3643 ,  A61M1/3644 ,  A61M5/148 ,  A61M2205/8225

    Abstract: Methods and systems for collection of blood components, such as plasma, from donors (D). One method includes the steps of collecting a unit of whole blood from a donor (D); forcing the collected blood unit through a plasma separator (90); accumulating the plasma in a container (94); and returning concentrated cells to the donor (D). One system includes a disposable blood collection set (14) and a reusable fixture (12) into which the collection set (14) can be mounted. The fixture (12) is operated by a self-contained energy source requiring no exterior electrical connection or other external source of energy.

    Abstract translation: 该装置对于血液分离特别有用，并且包括用于接收血液的可变体积容器（86），用于将血液分离成部件的分离器（90）和用于迫使来自容器的血液通过分离器迫使血液回到供体的强制施加装置 。 该装置是独立且便于携带的，施力装置（34b，24,52）由固定装置（12）保持，固定装置（12）也可释放地支撑分离器（90）和容器（86）。 施力装置包括可再充电的能量存储装置，例如用于保持用于膨胀囊（34b）以压缩容器（86）的压缩气体的可替换模块（c）的装置。 电气和机械存储装置是描述的替代方案。

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