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    INTRAVENOUS PUMPING AIR MANAGEMENT SYSTEMS AND METHODS
    2.
    发明申请
    INTRAVENOUS PUMPING AIR MANAGEMENT SYSTEMS AND METHODS 审中-公开
    空调泵送空气管理系统及方法

    公开(公告)号：WO2012128816A2

    公开(公告)日：2012-09-27

    申请号：PCT/US2011/067569

    申请日：2011-12-28

    Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  DUDAR, Thomas ,  KROGH, Ross ,  MARTUCCI, James ,  STERNBERG, Shmuel

    Inventor： DUDAR, Thomas ,  KROGH, Ross ,  MARTUCCI, James ,  STERNBERG, Shmuel

    IPC: A61M5/36 ,  A61M5/38

    CPC classification number: A61M5/172 ,  A61M5/36 ,  A61M5/365 ,  A61M5/38 ,  A61M5/385 ,  A61M2205/60

    Abstract: An intravenous ("IV") liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).

    Abstract translation: 静脉内（“IV”）液体输送系统包括：IV泵管组; 一个穿梭泵或膜泵驱动器，可与IV泵管组一起操作; 上游和下游阀致动器可与IV泵管组一起操作; 所述IV泵管组包括排气装置; 空气检测器，被配置为感测IV泵管组中的空气; 控制单元，其配置和布置成（i）打开上游阀致动器并关闭下游阀致动器以允许泵致动器将液体引入IV泵管组的泵致动部分，以及（ii）关闭上游阀致动器 并且打开下游阀致动器以允许泵致动器将液体推出泵致动部分，该系统构造成在根据（i）和（i）和（i））操作上游和下游阀致动器期间尝试经由除气装置去除空气， ⅱ）。

    HYDROPHOBIC AMMONIA SENSING MEMBRANE
    3.
    发明申请
    HYDROPHOBIC AMMONIA SENSING MEMBRANE 审中-公开
    HYDROPHOBIC AMMONIA感光膜

    公开(公告)号：WO2003052406A1

    公开(公告)日：2003-06-26

    申请号：PCT/US2002/029976

    申请日：2002-09-20

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： STERNBERG, Shmuel ,  BOGGS, Daniel ,  YEH, Rosa ,  PAN, LI

    IPC: G01N31/22

    CPC classification number: G01N31/224 ,  Y10T436/175383 ,  Y10T436/25875

    Abstract: A membrane capable of sensing ammmonia dissolved in solution is provided. The membrane includes a hydrophobic polymer layer that has a mircroporous structure and contains a pH indicator embedded therein. The hydrophobic polymer is selected from the group of flourinated polymers such as teflon (PTFE) or polyvinylidene difluoride.

    Abstract translation: 提供了能够感测溶解在溶液中的氨的膜。 膜包括疏水性聚合物层，其具有微孔结构并且包含嵌入其中的pH指示剂。 疏水性聚合物选自聚四氟乙烯（PTFE）或聚偏二氟乙烯等多元聚合物。

    PREPARATION OF SUBMICRON SIZED NANOPARTICLES VIA DISPERSION AND SOLVENT OR LIQUID PHASE REMOVAL
    5.
    发明申请
    PREPARATION OF SUBMICRON SIZED NANOPARTICLES VIA DISPERSION AND SOLVENT OR LIQUID PHASE REMOVAL 审中-公开
    通过分散和溶剂或液相去除制备亚微米级纳米粒子

    公开(公告)号：WO2003026611A2

    公开(公告)日：2003-04-03

    申请号：PCT/US2002/030447

    申请日：2002-09-25

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： BRYNJELSEN, Sean ,  STERNBERG, Shmuel ,  DUNHAM, Andrew, J. ,  DOTY, Mark, J. ,  KIPP, James, E. ,  JAYSWAL, Nailesh ,  NARAYANAN, Krishnaswamy

    IPC: A61K9/00

    CPC classification number: A61K9/14 ,  A61K9/145 ,  A61K9/5169 ,  A61K9/5192 ,  B01J13/04

    Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by sonicating to evaporate a portion of the organic phase or by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase havingthe poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.

    Abstract translation: 本发明涉及通过超声波蒸发一部分有机相或通过冻干具有有机相的多相体系的分散体或微分散体来制备水溶性差的化合物的亚微米尺寸的纳米颗粒的方法 相和水相，有机相中含有难溶于水的有机化合物。 该方法优选用于制备适用于体内递送的水溶性差的药物活性化合物的纳米颗粒，特别是通过肠胃外途径。

    MULTIPLE LAYER, FORMED-IN-PLACE IMMUNOISOLATION MEMBRANE STRUCTURES FOR IMPLANTATION OF CELLS IN HOST TISSUE
    6.
    发明申请
    MULTIPLE LAYER, FORMED-IN-PLACE IMMUNOISOLATION MEMBRANE STRUCTURES FOR IMPLANTATION OF CELLS IN HOST TISSUE 审中-公开
    多层，形成的免疫组织膜结构，用于植入宿主细胞中的细胞

    公开(公告)号：WO1996036296A1

    公开(公告)日：1996-11-21

    申请号：PCT/US1996006826

    申请日：1996-05-13

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： BAXTER INTERNATIONAL INC. ,  PAULEY, Robin, G. ,  McLARTY, Donna, L. ,  KHARE, Atul, R. ,  STERNBERG, Shmuel ,  BOGGS, Daniel, R. ,  NEUENFELDT, Steven ,  JONES, Mark ,  BRAUKER, James, H. ,  MARTINSON, Laura, A.

    IPC: A61F02/02

    CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61L27/38

    Abstract: A permeable structure (16) forms a chamber (12) to hold living cells (14). The structure includes a first permeable region (18) surrounding at least a portion of the chamber (12) having a confirmation that, when implanted is host tissue, substantially blocks penetration of host cells into the chamber (12) while permitting solute transport. The structure (16) also includes a second permeable region (20) overlaying the first permeable region (18) having a confirmation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region (22) is located between the first (18) and second (20) permeable regions. The third region (22) comprises a solution of polymer material formed in place between the first (18) and second (20) permeable regions. The third permeable region (22) bonds the first (18) and second (20) permeable regions together. The third permeable region (22) also has a confirmation that, when implanted in host tissue, permits solute transport between the first (18) and second (20) permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first (18) and second (20) regions. The third, formed-in-place region (22) can also have a confirmation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane (22) is sufficient high that it does not adversely effect the permability value desired for the overall multiple layer structure (16).

    Abstract translation: 可渗透结构（16）形成容纳活细胞（14）的腔室（12）。 该结构包括围绕腔室（12）的至少一部分的第一可渗透区域（18），其确认当植入的是宿主组织时，基本上阻止宿主细胞渗入腔室（12），同时允许溶质运输。 结构（16）还包括覆盖第一可渗透区域（18）的第二可渗透区域（20），其确认当植入宿主组织时，与允许溶质运输的宿主组织形成可渗透界面。 第三可渗透区域（22）位于第一（18）和第二（20）可渗透区域之间。 第三区域（22）包括在第一（18）和第二（20）可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域（22）将第一（18）和第二（20）可渗透区域结合在一起。 第三渗透区域（22）还确认，当植入到宿主组织中时，允许第一（18）和第二（20）可渗透区域之间的溶质传输在一起，提供坚固的层压结构，其抵抗植入期间的分层，由 细胞浸润到第一（18）和第二（20）区域之间的不连续空间。 第三个就地区域（22）也可以具有提供免疫隔离效果的确认。 此外，第三就地形成膜（22）的渗透性足够高，使得其不会对整个多层结构（16）所期望的渗透性值产生不利影响。

    DEVICE TO INDICATE PRIMING OF AN INFUSION LINE
    8.
    发明申请
    DEVICE TO INDICATE PRIMING OF AN INFUSION LINE 审中-公开
    用于显示输注线的预处理的装置

    公开(公告)号：WO2010030602A1

    公开(公告)日：2010-03-18

    申请号：PCT/US2009/056231

    申请日：2009-09-08

    Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  STERNBERG, Shmuel ,  DESAI, Siddharth, B. ,  BLACK, Larry ,  PAULEY, Robin, G.

    Inventor： STERNBERG, Shmuel ,  DESAI, Siddharth, B. ,  BLACK, Larry ,  PAULEY, Robin, G.

    IPC: A61M5/38 ,  A61M39/20

    CPC classification number: G01D7/005 ,  A61M5/141 ,  A61M5/3146 ,  A61M5/385 ,  A61M39/10 ,  A61M39/20 ,  A61M2005/1402 ,  A61M2005/3125 ,  A61M2039/205 ,  A61M2205/331 ,  A61M2205/7536

    Abstract: A priming indicator for a fluid infusion system includes a luer cap (20) or other component of the infusion system having an indicator surface (22) covered by a membrane (24). The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.

    Abstract translation: 用于流体输注系统的起动指示器包括输注系统的路厄帽（20）或其他部件，其具有由膜（24）覆盖的指示器表面（22）。 当膜干燥时，膜呈现第一视觉特征，例如不透明的，并且当湿时呈现第二特性，例如变得不透明。 一旦膜变湿，可以设置在至少部分地被膜覆盖的杆上的表面上的标记变得可见，从而指示固定有鲁尔帽的静脉内管已被引发或几乎被引发。 可以在输液器的上游端（例如在提供流体供应的医疗袋的端口处）使用指示器，以指示医疗袋中的低水平的流体。

    SYSTEM FOR FILTERING MEDICAL AND BIOLOGICAL FLUIDS
    10.
    发明申请
    SYSTEM FOR FILTERING MEDICAL AND BIOLOGICAL FLUIDS 审中-公开
    用于过滤医疗和生物流体的系统

    公开(公告)号：WO1998013131A1

    公开(公告)日：1998-04-02

    申请号：PCT/US1997017071

    申请日：1997-09-22

    Applicant: BAXTER INTERNATIONAL INC.

    Inventor： BAXTER INTERNATIONAL INC. ,  PRINCE, Paul, R. ,  PEKKARINEN, Michael, O. ,  BELLAMY, David, Jr. ,  STERNBERG, Shmuel

    IPC: B01D65/02

    CPC classification number: B01D65/08 ,  A61M1/262 ,  A61M1/265 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/3334 ,  B01D39/1692 ,  B01D61/147 ,  B01D61/22 ,  B01D63/16 ,  B01D69/02 ,  B01D2321/20 ,  B01D2321/2025 ,  B01D2321/2058 ,  B01D2321/2066 ,  A61M2202/0042 ,  A61M2202/0035

    Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles (104) and (108) which are differently sized or shaped and in which a first type of red cell particle (104) may be deformable at a relatively lower force and/or faster rate than a second type of white cell particle (108). A filter membrane (100) is provided having pores (102) with substantially precisely dimensioned pore sizes, with the pores (102) being dimensioned to allow passage of the first type of particle (104) without distortion or only minimal distortion and passage of the second type of particle (108) only with substantial distortion. Because the filter membrane (100) has precisely dimensioned pores (102), with spacing between the pores (102) being maintained despite the smaller interval between the pores (102), the porosity of the membrane (100) may be relatively much greater, allowing faster filtration rates while reducing shear exposure time and consequently reducing particle damage. Various methods for preventing clogging of the membrane (100) are also disclosed.

    Abstract translation: 一种用于过滤医疗和生物流体悬浮液的方法和装置，其一个方面是分离包含不同尺寸或形状的至少两种类型的颗粒（104）和（108）的悬浮液，其中第一类型的红细胞 颗粒（104）可以以比第二类型的白细胞颗粒（108）更低的力和/或更快的速率变形。 提供了一种过滤膜（100），其具有孔（102），其具有基本上精确尺寸的孔径，其中孔（102）的尺寸被设计成允许第一类型的颗粒（104）通过而没有变形或只有最小的变形和通过 第二类型的粒子（108）仅具有实质的变形。 由于过滤膜（100）具有精确尺寸的孔（102），尽管孔（102）之间的间隔较小，孔（102）之间的间隔保持不变，膜（100）的孔隙率可以相对大得多， 允许更快的过滤速率，同时减少剪切暴露时间，从而减少颗粒损伤。 还公开了防止膜（100）堵塞的各种方法。

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