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    MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY
    14.
    发明申请
    MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY 审中-公开
    使用相敏感光学相干反射测量法测量神经功能

    公开(公告)号：US20160317076A1

    公开(公告)日：2016-11-03

    申请号：US15140172

    申请日：2016-04-27

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Taner Akkin ,  Thomas E. Milner ,  Digant P. Dave ,  H. Grady Rylander, III

    IPC: A61B5/00

    CPC classification number: A61B5/4041 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0082 ,  A61B5/40 ,  A61B5/4029 ,  A61B5/6821 ,  A61B5/7225 ,  A61B5/7282 ,  A61N1/00 ,  A61N1/3605 ,  A61N5/0622

    Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less than 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.

    Abstract translation: 公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。 提供的方法，设备和系统可以采用相敏光学低相干反射计。 此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。 根据一些实施方案，不需要外源化学品或反射离子涂层。 可以检测到振幅小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。 系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。 它们也可用于检测各种药理学试剂的作用。

    SPECTRALLY-ENCODED HIGH-EXTINCTION POLARIZATION MICROSCOPE AND METHODS OF USE
    15.
    发明申请
    SPECTRALLY-ENCODED HIGH-EXTINCTION POLARIZATION MICROSCOPE AND METHODS OF USE 审中-公开
    高分辨率高分辨率极化显微镜及其使用方法

    公开(公告)号：US20160154229A1

    公开(公告)日：2016-06-02

    申请号：US14963900

    申请日：2015-12-09

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Thomas E. Milner ,  Biwei Yin ,  Jeffrey Russel Kuhn

    IPC: G02B21/00 ,  G02B21/06 ,  G06T7/00 ,  H04N5/225 ,  H04N5/372 ,  G02B21/36 ,  G02B21/26

    CPC classification number: G02B21/0092 ,  G02B9/04 ,  G02B21/06 ,  G02B21/26 ,  G02B21/36 ,  G02B27/28 ,  G06T7/80 ,  H04N5/2254 ,  H04N5/2256 ,  H04N5/372

    Abstract: Described herein is a polarization microscope that uses spectral-encoding of the polarization state for cellular imaging. The spectral-encoded polarization microscope is both sufficiently fast for cellular imaging and is compatible with high extinction optics required to image molecular structures and assemblies. The spectral-encoded microscope allows for the polarization state of light presented to the specimen to sample discrete states over the entirety of the Poincaré sphere while simultaneously giving a null measurement of the observed cellular birefringence. Sampling over the entire Poincaré sphere allows the microscope to determine of specimen phase retardation due to both linear and circular birefringence. The spectral-encoded polarization microscope can be operated in a slightly off-null state that will improve signal-to-noise.

    Abstract translation: 本文描述的是使用偏振状态的光谱编码进行细胞成像的偏振显微镜。 光谱编码的偏振显微镜对于细胞成像来说足够快，并且与成像分子结构和组件所需的高消光光学元件兼容。 光谱编码的显微镜允许呈现给样品的光的偏振状态在整个庞加莱球体上采样离散状态，同时给出观察到的细胞双折射的无效测量。 在整个Poincaré球体上进行取样可使显微镜确定由于线性和圆形双折射引起的样品相位延迟。 频谱编码的偏振显微镜可以在稍微偏离非零状态下工作，这将改善信噪比。

    SYSTEM, DEVICES, AND METHODS FOR OPTICALLY CLEARING TISSUE
    16.
    发明申请
    SYSTEM, DEVICES, AND METHODS FOR OPTICALLY CLEARING TISSUE 有权
    用于光学清除组织的系统，装置和方法

    公开(公告)号：US20130178916A1

    公开(公告)日：2013-07-11

    申请号：US13693974

    申请日：2012-12-04

    Applicant: Board of Regents, The University of Texas System

    Inventor： Christopher G. Rylander ,  Thomas E. Milner ,  Oliver Stumpp ,  J. Stuart Nelson

    IPC: A61N5/06

    CPC classification number: A61N5/06 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/444 ,  A61B18/14 ,  A61B18/1815 ,  A61B18/203 ,  A61B2017/306 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00452 ,  A61B2018/00994 ,  A61N5/0616 ,  A61N5/062 ,  A61N2005/063 ,  A61N2005/0649

    Abstract: Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of the base, a brim fixed to the base, an inlet port in the base, an exit port in the base, and a handpiece interface tab fixed to the side of the base opposite the array of pins, applying a mechanical force to the tissue, and illuminating said tissue with at least one wavelength of light through the optical clearing device. A method may further comprise controlling the temperature of the tissue illuminated.

    Abstract translation: 本公开的实施例提供用于非侵入性地修改，维持或控制局部组织光学性质的系统，装置和方法。 本公开的方法和装置可用于光学清除组织，例如用于诊断和/或治疗目的。 光学清理组织的方法可以包括使组织与光学清除装置接触，所述光学清除装置具有底座，固定到基座的一侧的销的阵列，固定到基座的边缘，基座中的入口端口，出口 在底座中，以及手柄接口片，其固定在基座对面的与针阵列相对的一侧上，向组织施加机械力，并且通过光学清除装置用至少一个波长的光照射所述组织。 方法还可以包括控制照射的组织的温度。

    Hydrophobic Paramagnetic Nanoparticles as Intelligent Crude Oil Tracers
    18.
    发明申请
    Hydrophobic Paramagnetic Nanoparticles as Intelligent Crude Oil Tracers 审中-公开
    疏水顺磁纳米颗粒作为智能原油示踪剂

    公开(公告)号：US20150376493A1

    公开(公告)日：2015-12-31

    申请号：US14765426

    申请日：2014-01-15

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Chun Huh ,  Nabijan Nizamidin ,  Gary A. Pope ,  Thomas E. Milner ,  Bingqing Wang

    IPC: C09K8/58 ,  G01V3/26 ,  C09K8/80 ,  E21B43/16 ,  E21B47/00

    CPC classification number: C09K8/58 ,  C09K8/805 ,  C09K2208/10 ,  E21B43/16 ,  E21B47/00 ,  G01V3/26

    Abstract: Hydrophobic paramagnetic nanoparticles can be injected with the enhanced oil recovery injection water by incorporating them inside of surfactant micelles to serve as an oil tracer. A variety of paramagnetic nanoparticles that show different susceptibility and magnetization responses to applied magnetic oscillation can be injected at different injectors, so that the origin of the oil from the different enhanced oil recovery patterns could be quantitatively identified. The concentrations of the nanoparticles in the produced crude oil and brine can be easily and instantly measured individually, employing the magnetic susceptibility meter without contacting the fluids directly.

    Abstract translation: 疏水性顺磁性纳米颗粒可以通过将其加入到表面活性剂胶束内作为油追踪剂，注入强化采油注入水。 可以在不同的注射器处注入对应用的磁振荡显示不同的磁化率和磁化响应的各种顺磁性纳米粒子，从而可以定量地鉴定来自不同强化油回收模式的油的来源。 生产的原油和盐水中的纳米颗粒的浓度可以单独容易地立即测量，使用磁化率计直接接触流体。

    OCT USING SPECTRALLY RESOLVED BANDWIDTH
    20.
    发明申请
    OCT USING SPECTRALLY RESOLVED BANDWIDTH 有权
    OCT使用光谱分辨带

    公开(公告)号：US20130338495A1

    公开(公告)日：2013-12-19

    申请号：US13904849

    申请日：2013-05-29

    Applicant: Board of Regents, The University of Texas System

    Inventor： Marc D. Feldman ,  Thomas E. Milner ,  Jung-Hwan Oh ,  Eunha Kim ,  Karathik Kumar ,  Jonathan C. Condit ,  Robert Grant ,  Nathaniel J. Kemp ,  Jihoon Kim ,  Shaochen Chen ,  Li-Hsin Han

    IPC: A61B5/00

    CPC classification number: A61B5/0073 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852

    Abstract: The embodiments disclosed herein is related to a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may be comprised and encompass spatial, angle, spectral and polarization domains. More specifically, the embodiments disclosed herein is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically. The multichannel optical coherence tomographic methods can be incorporated into an endoscopic probe for imaging a patient.

    Abstract translation: 本文公开的实施例涉及利用多个信道信道的浑浊（即散射）材料的光学相干断层成像系统。 可以包括多个信道信道并且包括空间，角度，频谱和极化域。 更具体地说，这里公开的实施例涉及用于利用光源，系统或接收器的方法和装置，该光源，系统或接收器能够提供（源），处理（系统）或记录（接收）多个光谱信息通道，用于光学相干断层成像 浑浊的材料。 在这些方法和装置中，可以由源提供的，由系统处理的或由接收器记录的光谱信息的多个通道的多样性被用于同时输送与成像成像的混浊物质有关的空间，光谱或偏振信息。 多通道光学相干断层摄影方法可以并入用于成像患者的内窥镜探针中。

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