公开(公告)号：WO2007033175A1

公开(公告)日：2007-03-22

申请号：PCT/US2006/035490

申请日：2006-09-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BERGSTROM, Carl, P. ,  BENDER, John, A. ,  GENTLES, Robert, G. ,  HEWAWASAM, Piyasena ,  HUDYMA, Thomas, W. ,  KADOW, John, F. ,  MARTIN, Scott, W. ,  REGUEIRO-REN, Alicia ,  YEUNG, Kap-Sun ,  TU, Yong ,  GRANT-YOUNG, Katharine, A. ,  ZHENG, Xiaofan

Inventor： BERGSTROM, Carl, P. ,  BENDER, John, A. ,  GENTLES, Robert, G. ,  HEWAWASAM, Piyasena ,  HUDYMA, Thomas, W. ,  KADOW, John, F. ,  MARTIN, Scott, W. ,  REGUEIRO-REN, Alicia ,  YEUNG, Kap-Sun ,  TU, Yong ,  GRANT-YOUNG, Katharine, A. ,  ZHENG, Xiaofan

IPC: C07D487/04 ,  A61K31/55 ,  A61P31/14

CPC classification number: C07D491/14 ,  C07D487/04

Abstract: The invention encompasses compounds and salts of Formulas (I), (II), (III), and (IV) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式（I），（II），（III）和（IV）的化合物和盐以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2015160641A2

公开(公告)日：2015-10-22

申请号：PCT/US2015/025249

申请日：2015-04-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： CHUPAK, Louis S. ,  DING, Min ,  MARTIN, Scott W. ,  ZHENG, Xiaofan ,  HEWAWASAM, Piyasena ,  CONNOLLY, Timothy P. ,  XU, Ningning ,  YEUNG, Kap-Sun ,  ZHU, Juliang ,  LANGLEY, David R. ,  TENNEY, Daniel J. ,  SCOLA, Paul Michael

IPC: C07D319/18 ,  A61K31/357

CPC classification number: C07D319/18 ,  A61K31/165 ,  A61K31/277 ,  A61K31/357 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C233/36 ,  C07C235/42 ,  C07C255/13 ,  C07C255/54 ,  C07C271/28 ,  C07C317/22 ,  C07D207/26 ,  C07D207/335 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D217/16 ,  C07D231/56 ,  C07D239/26 ,  C07D261/08 ,  C07D271/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/463 ,  A61K2300/00

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract translation: 本公开一般涉及可用作免疫调节剂的化合物。 本文提供的化合物，包含这些化合物的组合物及其使用方法。 本公开还涉及包含至少一种根据本公开的化合物的药物组合物，其可用于治疗各种疾病，包括癌症和感染性疾病。

公开(公告)号：WO2011075439A1

公开(公告)日：2011-06-23

申请号：PCT/US2010/060077

申请日：2010-12-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BELEMA, Makonen ,  ROMINE, Jeffrey, Lee ,  NGUYEN, Van, N. ,  WANG, Gan ,  LOPEZ, Omar, D. ,  ST. LAURENT, Denis, R. ,  CHEN, Qi ,  BENDER, John, A. ,  YANG, Zhong ,  HEWAWASAM, Piyasena ,  XU, Ningning ,  MEANWELL, Nicholas, A. ,  EASTER, John, A. ,  SU, Bao-Ning ,  SMITH, Michael, J.

Inventor： BELEMA, Makonen ,  ROMINE, Jeffrey, Lee ,  NGUYEN, Van, N. ,  WANG, Gan ,  LOPEZ, Omar, D. ,  ST. LAURENT, Denis, R. ,  CHEN, Qi ,  BENDER, John, A. ,  YANG, Zhong ,  HEWAWASAM, Piyasena ,  XU, Ningning ,  MEANWELL, Nicholas, A. ,  EASTER, John, A. ,  SU, Bao-Ning ,  SMITH, Michael, J.

IPC: C07D403/14 ,  C07D405/14

CPC classification number: C07D403/14 ,  C07D405/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2011059887A1

公开(公告)日：2011-05-19

申请号：PCT/US2010/055565

申请日：2010-11-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LAVOIE, Rico ,  BENDER, John A. ,  YANG, Zhong ,  BELEMA, Makonen ,  LOPEZ, Omar D. ,  CHEN, Qi ,  WANG, Gan ,  HEWAWASAM, Piyasena

Inventor： LAVOIE, Rico ,  BENDER, John A. ,  YANG, Zhong ,  BELEMA, Makonen ,  LOPEZ, Omar D. ,  CHEN, Qi ,  WANG, Gan ,  HEWAWASAM, Piyasena

IPC: C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/506 ,  A61P31/14

CPC classification number: C07D309/06 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2010030592A1

公开(公告)日：2010-03-18

申请号：PCT/US2009/056166

申请日：2009-09-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  YEUNG, Kap-Sun ,  PARCELLA, Kyle E. ,  BENDER, John A. ,  BENO, Brett R. ,  GRANT-YOUNG, Katharine A. ,  HAN, Ying ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  NICKEL, Andrew

Inventor： YEUNG, Kap-Sun ,  PARCELLA, Kyle E. ,  BENDER, John A. ,  BENO, Brett R. ,  GRANT-YOUNG, Katharine A. ,  HAN, Ying ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  NICKEL, Andrew

IPC: C07D307/84 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D453/00 ,  C07D491/10 ,  A61K31/14 ,  A61P31/14

CPC classification number: C07D307/84 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D453/00 ,  C07D491/10

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2009067108A1

公开(公告)日：2009-05-28

申请号：PCT/US2007/085183

申请日：2007-11-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BENDER, John A. ,  DING, Min ,  GENTLES, Robert G. ,  HEWAWASAM, Piyasena

Inventor： BENDER, John A. ,  DING, Min ,  GENTLES, Robert G. ,  HEWAWASAM, Piyasena

IPC: C07D487/08 ,  A61K31/55 ,  A61P31/12

CPC classification number: C07D487/08

Abstract: The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式（I）的化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：WO2007140200A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/069526

申请日：2007-05-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  GENTLES, Robert G. ,  DING, Min ,  HEWAWASAM, Piyasena

Inventor： GENTLES, Robert G. ,  DING, Min ,  HEWAWASAM, Piyasena

CPC classification number: C07D487/04

Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Abstract translation: 本发明包括式I化合物以及使用该化合物的组合物和方法。 这些化合物对丙型肝炎病毒（HCV）具有活性，可用于治疗感染HCV的患者。

公开(公告)号：WO2007008657A2

公开(公告)日：2007-01-18

申请号：PCT/US2006/026513

申请日：2006-07-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  HEWAWASAM, Piyasena ,  DING, Min ,  SUN, Li-Qiang ,  SCOLA, Paul Michael

Inventor： HEWAWASAM, Piyasena ,  DING, Min ,  SUN, Li-Qiang ,  SCOLA, Paul Michael

CPC classification number: C07K5/0808 ,  A61K38/00

Abstract: The present disclosure relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的三肽化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2003099274A1

公开(公告)日：2003-12-04

申请号：PCT/US2003/015755

申请日：2003-05-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Xiangdong, Alan ,  SUN, Li-Quang ,  SIT, Sing-Yuen ,  SIN, Ny ,  SCOLA, Paul, Michael ,  HEWAWASAM, Piyasena ,  GOOD, Andrew, Charles ,  CHEN, Yan ,  CAMPBELL, Jeffrey, Allen

Inventor： WANG, Xiangdong, Alan ,  SUN, Li-Quang ,  SIT, Sing-Yuen ,  SIN, Ny ,  SCOLA, Paul, Michael ,  HEWAWASAM, Piyasena ,  GOOD, Andrew, Charles ,  CHEN, Yan ,  CAMPBELL, Jeffrey, Allen

IPC: A61K31/40

CPC classification number: A61K38/06 ,  A61K31/40 ,  A61K38/00 ,  A61K38/005 ,  A61K45/06 ,  C07D207/16 ,  C07D217/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D491/04 ,  C07K5/06034 ,  C07K5/06052 ,  C07K5/0808 ,  C07K5/0827 ,  A61K2300/00

Abstract: Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R 1 , R 2 , R 3 , R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.

Abstract translation: 公开了具有以下通式的丙型肝炎病毒抑制剂：（I）其中R1，R2，R3，R'，B，Y和X在说明书中描述。 还公开了包含化合物的组合物和使用该化合物来抑制HCV的方法。

公开(公告)号：WO2023283523A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/073244

申请日：2022-06-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： CONNOLLY, Timothy P. ,  HEWAWASAM, Piyasena ,  ZHU, Juliang ,  ST. LAURENT, Denis R. ,  YEUNG, Kap-Sun ,  SCOLA, Paul Michael

IPC: C07D319/18 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61P35/00 ,  A61K31/497 ,  A61K31/4155 ,  A61K31/5355 ,  A61K31/4433 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/427

Abstract: The present disclosure generally relates to 2,3-dihydrobenzo[b][1,4]dioxin-6-yl containing compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.