公开(公告)号：WO2009102694A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033646

申请日：2009-02-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  MAKONEN, Belema ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  A61K31/517 ,  A61P31/00

CPC classification number: C07D403/14

Abstract: The present disclosure relates to compounds of formula (I), their compositions and their use in the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及式（I）的化合物，其组合物及其在治疗丙型肝炎病毒（HCV）感染中的用途。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2021067521A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053667

申请日：2020-10-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： YEUNG, Kap-Sun ,  ST. LAURENT, Denis R. ,  SUN, Li-Qiang ,  YIN, Zhiwei ,  GRANT-YOUNG, Katharine A. ,  SCOLA, Paul Michael

IPC: A61P35/00 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D411/14 ,  C07D487/04 ,  C07D498/14 ,  C07D513/04

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：WO2018118848A1

公开(公告)日：2018-06-28

申请号：PCT/US2017/067198

申请日：2017-12-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： YEUNG, Kap-Sun ,  GRANT-YOUNG, Katharine A. ,  SUN, Li-Qiang ,  LANGLEY, David R. ,  ST. LAURENT, Denis R. ,  SCOLA, Paul Michael

IPC: C07D401/14 ,  A61P37/02 ,  A61K31/444 ,  A61K31/498

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：WO2011082077A1

公开(公告)日：2011-07-07

申请号：PCT/US2010/061855

申请日：2010-12-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LOPEZ, Omar D. ,  ST. LAURENT, Denis R. ,  GOODRICH, Jason ,  ROMINE, Jeffrey Lee ,  SERRANO-WU, Michael ,  YANG, Fukang ,  KAKARLA, Ramesh ,  YANG, Xuejie ,  QIU, Yuping ,  SNYDER, Lawrence B.

Inventor： LOPEZ, Omar D. ,  ST. LAURENT, Denis R. ,  GOODRICH, Jason ,  ROMINE, Jeffrey Lee ,  SERRANO-WU, Michael ,  YANG, Fukang ,  KAKARLA, Ramesh ,  YANG, Xuejie ,  QIU, Yuping ,  SNYDER, Lawrence B.

IPC: C07D231/12 ,  C07D233/64 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/341 ,  A61K31/381 ,  A61K31/41 ,  A61P31/14

CPC classification number: A61K31/415 ,  A61K31/4196 ,  A61K31/4245 ,  C07D231/12 ,  C07D233/58 ,  C07D233/64 ,  C07D249/06 ,  C07D249/08 ,  C07D249/12 ,  C07D263/32 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.

Abstract translation: 本公开一般涉及抗病毒化合物，更具体地涉及可以抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能的化合物，包含这些化合物的组合物，以及用于抑制NS5A蛋白功能的方法。

公开(公告)号：WO2010117635A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/028456

申请日：2010-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BENDER, John A. ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  LOPEZ, Omar D. ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  WANG, Gan ,  XU, Ningning ,  BELEMA, Makonen

Inventor： BENDER, John A. ,  HEWAWASAM, Piyasena ,  KADOW, John F. ,  LOPEZ, Omar D. ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  WANG, Gan ,  XU, Ningning ,  BELEMA, Makonen

IPC: C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  A61K31/4178 ,  A61P31/14

CPC classification number: C07D403/04 ,  C07D403/14 ,  C07D405/14

Abstract: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

Abstract translation: 本公开涉及如说明书中定义的式（I）新化合物和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。

公开(公告)号：WO2023283523A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/073244

申请日：2022-06-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： CONNOLLY, Timothy P. ,  HEWAWASAM, Piyasena ,  ZHU, Juliang ,  ST. LAURENT, Denis R. ,  YEUNG, Kap-Sun ,  SCOLA, Paul Michael

IPC: C07D319/18 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61P35/00 ,  A61K31/497 ,  A61K31/4155 ,  A61K31/5355 ,  A61K31/4433 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/427

Abstract: The present disclosure generally relates to 2,3-dihydrobenzo[b][1,4]dioxin-6-yl containing compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：WO2019169123A1

公开(公告)日：2019-09-06

申请号：PCT/US2019/020032

申请日：2019-02-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： YEUNG, Kap-Sun ,  ST. LAURENT, Denis R. ,  LANGLEY, David R. ,  SCOLA, Paul Michael

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  C07D213/85 ,  C07D401/12 ,  A61P31/00 ,  A61P35/00

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：WO2009102633A1

公开(公告)日：2009-08-20

申请号：PCT/US2009/033380

申请日：2009-02-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61P31/14

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052

Abstract: The present disclosure relates to compounds of structure (I), compositions and Methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及结构（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法的化合物。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009102325A1

公开(公告)日：2009-08-20

申请号：PCT/US2008/053779

申请日：2008-02-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  A61P31/00 ,  A61K31/41

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds Formule (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in. the treatment of HCV infection.

Abstract translation: 本公开涉及化合物（I），治疗丙型肝炎病毒（HCV）感染的组合物和方法。 还公开了含有这些化合物的药物组合物和在治疗HCV感染中使用这些化合物的方法。

公开(公告)号：WO2008021927A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075544

申请日：2007-08-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

Inventor： BACHAND, Carol ,  BELEMA, Makonen ,  DEON, Daniel H. ,  GOOD, Andrew C. ,  GOODRICH, Jason ,  JAMES, Clint A. ,  LAVOIE, Rico ,  LOPEZ, Omar D. ,  MARTEL, Alain ,  MEANWELL, Nicholas A. ,  NGUYEN, Van N. ,  ROMINE, Jeffrey Lee ,  RUEDIGER, Edward H. ,  SNYDER, Lawrence B. ,  ST. LAURENT, Denis R. ,  YANG, Fukang ,  LANGLEY, David R. ,  WANG, Gan ,  HAMANN, Lawrence G.

IPC: C07D401/14 ,  C07D403/14 ,  A61P31/12 ,  A61K31/4025 ,  A61K31/4178

CPC classification number: C07D233/64 ,  A61K31/4178 ,  A61K45/06 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07F5/025 ,  C07F7/0812

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。