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公开(公告)号：WO2009126380A8
公开(公告)日：2010-11-04
申请号：PCT/US2009036086
申请日：2009-03-04
Applicant: SINGULEX INC , GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
IPC: G01N33/53
CPC classification number: G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
Abstract translation: 本发明公开了使用分子的高灵敏度检测来检测和监测受试者的状况的方法。 本发明提供了一种用于检测或监测受试者中的病症的方法，包括检测来自受试者的第一样品中的第一标志物并检测第二标志物，其中第一标记物包含生物标志物，例如心肌肌钙蛋白I（cTn1） 或血管内皮生长因子（VEGF），并且其中第一标记物的检测限小于约10pg / ml。 第二标记可以是生物标志物，生理学标记，分子标记或遗传标记。
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公开(公告)号：WO2012172376A3
公开(公告)日：2013-11-21
申请号：PCT/GB2012051397
申请日：2012-06-18
Applicant: PERSONNEL HYGIENE SERVICES LTD , TODD JOHN
Inventor： TODD JOHN
IPC: A47K10/48
CPC classification number: A47K10/48
Abstract: A hand dryer (1) includes a fan (4), and a housing defining a fan chamber (16) arranged to receive blown air from the fan (4). The fan chamber (16) comprises an outlet (44) defining the air outlet of the dryer (1) through which air is blown directly to the outside atmosphere. The fan chamber (16) is configured such that it tapers towards the outlet (44) to accelerate air flow therethrough. The outlet (44) comprises an elongate slot and the fan chamber (16) tapers to the elongate slot to optimise drying airflow for hand drying with the letterbox configuration providing an airflow which effectively spans a user's hands during drying.
Abstract translation: 手干燥器（1）包括风扇（4）和限定了用于接收来自风扇（4）的吹风的风扇室（16）的壳体。 风扇室（16）包括限定干燥器（1）的空气出口的出口（44），空气通过该出口直接吹向外部大气。 风扇室（16）构造成使得其朝向出口（44）逐渐变细，以加速通过其中的空气流动。 出口（44）包括细长的狭槽，并且风扇室（16）逐渐变细到细长槽，以优化干燥气流，以便用信箱配置进行手干，从而提供在干燥期间有效跨越使用者的手的气流。
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公开(公告)号：WO2009126380A3
公开(公告)日：2009-12-03
申请号：PCT/US2009036086
申请日：2009-03-04
Applicant: SINGULEX INC , GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
IPC: G01N33/53
CPC classification number: G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
Abstract translation: 本发明公开了使用分子的高灵敏度检测来检测和监测受试者状况的方法。 本发明提供了用于检测或监测受试者状况的方法，包括检测来自受试者的第一样品中的第一标志物和检测第二标志物，其中第一标志物包含生物标志物，例如心脏肌钙蛋白-I（cTnI） 或血管内皮生长因子（VEGF），并且其中第一标记的检测极限小于约10pg / ml。 第二个标记可以是生物标记，生理标记，分子标记或遗传标记。
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Patent Agency Ranking14.发明申请METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开标记物敏感性分析方法与组合物及分子检测
公开(公告)号：WO2008048371A2
公开(公告)日：2008-04-24
申请号：PCT/US2007008394
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
Abstract translation: 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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公开(公告)号：US779889A
公开(公告)日：1905-01-10
申请号：US1904198078
申请日：1904-03-14
Applicant: GEORGE WINFIELD WILSON , TODD JOHN
Inventor： TODD JOHN
CPC classification number: F28B1/02 , Y10S165/10 , Y10T137/86839
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17.发明申请METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开高灵敏度分析标记物和检测分子的方法和组合物
公开(公告)号：WO2008048371A9
公开(公告)日：2008-11-27
申请号：PCT/US2007008394
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
Abstract translation: 公开了用于单个生物分子的荧光检测的方法，试剂盒和组合物，例如， 使用高度敏感的荧光染料和具有一个询问空间的流动池用于通过聚焦激光束进行照射。 这些方法，试剂盒和组合物可用于确定样品中分子浓度达到1飞摩尔，1摩尔或更低的水平。 该方法，试剂盒和组合物还允许在很宽的范围，例如7个对数范围内测定浓度，而不需要样品稀释。
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公开(公告)号：WO2007114947A2
公开(公告)日：2007-10-11
申请号：PCT/US2007008506
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
IPC: G06F15/00
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。
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