公开(公告)号：AU2004304787A1

公开(公告)日：2005-07-07

申请号：AU2004304787

申请日：2004-08-10

Applicant: CALIFORNIA INST OF TECHN

Inventor： STUDER VINCENT ,  QUAKE STEPHEN R ,  ANDERSON W FRENCH ,  MAERKL SEBASTIAN J

IPC: B01L3/00 ,  F15C5/00

Abstract: Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.

公开(公告)号：CA2500283A1

公开(公告)日：2004-04-08

申请号：CA2500283

申请日：2003-09-24

Applicant: CALIFORNIA INST OF TECHN

Inventor： MAERKL SEBASTIAN J ,  QUAKE STEPHEN R ,  STUDER VINCENT ,  BAO XIAOYAN ,  THORSEN TODD A

IPC: B01L3/00 ,  F15C5/00 ,  F16K11/20 ,  F16K99/00 ,  B81B1/00

Abstract: High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these network s is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highl y complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.