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    MICROFLUIDIC LARGE SCALE INTEGRATION
    1.
    发明申请
    MICROFLUIDIC LARGE SCALE INTEGRATION 审中-公开
    微流化大规模集成

    公开(公告)号：WO2005060393A3

    公开(公告)日：2006-03-09

    申请号：PCT/US2004025946

    申请日：2004-08-10

    Applicant: CALIFORNIA INST OF TECHN ,  STUDER VINCENT ,  QUAKE STEPHEN R ,  ANDERSON W FRENCH ,  MAERKL SEBASTIAN J

    Inventor： STUDER VINCENT ,  QUAKE STEPHEN R ,  ANDERSON W FRENCH ,  MAERKL SEBASTIAN J

    IPC: F15C5/00 ,  F16K7/04 ,  F16K11/20

    CPC classification number: F15C5/00 ,  G06F17/5018 ,  G06F2217/16

    Abstract: Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.

    Abstract translation: 使用基本的物理参数，提出了使用多层软光刻制造微流体阀的设计和方法。 根据本发明的阀的实施例具有基本恒定厚度的弹性体膜部分，允许膜在其整个宽度上经受类似的施加压力的阻力。 用向上或向下可偏转膜制造的这种开关阀可以具有非常低的致动压力，并且可以用于实现积分功能，例如集成微流体芯片中的泵和混合器。 阀性能的特征在于在宽范围的设计参数下测量致动压力和流动阻力，并将其与有限元模拟和替代阀几何形状进行比较。

    MICROFLUIDIC LARGE SCALE INTEGRATION
    2.
    发明公开
    MICROFLUIDIC LARGE SCALE INTEGRATION 有权
    MIKROFLUIDISCHE集成在GROSSEM AUSMASS中

    公开(公告)号：EP1664601A4

    公开(公告)日：2006-11-02

    申请号：EP04820717

    申请日：2004-08-10

    Applicant: CALIFORNIA INST OF TECHN

    Inventor： STUDER VINCENT ,  QUAKE STEPHEN R ,  ANDERSON W FRENCH ,  MAERKL SEBASTIAN J

    IPC: F16K7/04 ,  F15C5/00 ,  F16K11/20

    CPC classification number: F15C5/00 ,  G06F17/5018 ,  G06F2217/16

    Abstract: Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.

    Abstract translation: 使用基本物理参数，提出了使用多层软光刻制造微流体阀门的设计和方法。 根据本发明的阀的实施例的特征在于具有基本恒定厚度的弹性体膜部分，从而允许膜在其整个宽度上经受与施加的压力类似的阻力。 用向上或向下可偏转的膜制造的这种开关阀可以具有极低的致动压力，并且可以用于实现集成微流体芯片中的泵和混合器等主动功能。 通过测量各种设计参数中的致动压力和流动阻力来表征阀门性能，并将其与有限元模拟和替代阀门几何形状进行比较。

    MICROFLUIDIC NUCLEIC ACID ANALYSIS
    5.
    发明公开
    MICROFLUIDIC NUCLEIC ACID ANALYSIS 有权
    MIKROFLUIDISCHENUKLEINSûUREANALYSE

    公开(公告)号：EP1546412A4

    公开(公告)日：2007-10-03

    申请号：EP03799829

    申请日：2003-10-02

    Applicant: CALIFORNIA INST OF TECHN

    Inventor： HONG JONG WOOK ,  STUDER VINCENT ,  ANDERSON W FRENCH ,  QUAKE STEPHEN R ,  LEADBETTER JARED

    IPC: B01L3/00 ,  C12M1/34 ,  C12Q1/68 ,  C07H19/00 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/10 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/1827 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12Q1/6806 ,  C12Q2565/629

    Abstract: Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. In accordance with one embodiment of the present invention, individual or small groups of cells or viruses may be isolated in microfluidic chambers by dilution, sorting, and/or segmentation. The isolated cells or viruses may be lysed directly in the microfluidic chamber, and the resulting nucleic acid purified by exposure to affinity beads. Subsequent elution of the purified nucleic acid may be followed by ligation and cell transformation, all within the same microfluidic chip. In one specific application, cell isolation, lysis, and nucleic acid purification may be performed utilizing a highly parallelized microfluidic architecture to construct gDNA and cDNA libraries.

    Abstract translation: 来自各种环境的细胞和病毒的核酸可利用微流体技术进行纯化和表达。 根据本发明的一个实施方案，可以通过稀释，分选和/或分割在微流体室中分离单个或小群细胞或病毒。 分离的细胞或病毒可以直接在微流体室中裂解，并且通过暴露于亲和珠来纯化所得的核酸。 随后纯化的核酸的洗脱可以在完全在相同的微流体芯片内进行连接和细胞转化。 在一个具体应用中，细胞分离，裂解和核酸纯化可以利用高度平行化的微流体结构来构建gDNA和cDNA文库。

    MICROFLUIDIC NUCLEIC ACID ANALYSIS
    6.
    发明专利
    MICROFLUIDIC NUCLEIC ACID ANALYSIS 未知

    公开(公告)号：AU2003299541A1

    公开(公告)日：2004-05-25

    申请号：AU2003299541

    申请日：2003-10-02

    Applicant: CALIFORNIA INST OF TECHN

    Inventor： QUAKE STEPHEN R ,  LEADBETTER JARED ,  HONG JONG WOOK ,  STUDER VINCENT ,  ANDERSON W FRENCH

    IPC: B01L3/00 ,  C12M1/34

    Abstract: Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. Individual or small groups of cells or viruses may be isolated in microfluidic chambers by dilution, sorting, and/or segmentation. The isolated cells or viruses may be lysed directly in the microfluidic chamber, and the resulting nucleic acid purified by exposure to affinity beads. Subsequent elution of the purified nucleic acid may be followed by ligation and cell transformation, all within the same microfluidic chip. Cell isolation, lysis, and nucleic acid purification may be performed utilizing a highly parallelized microfluidic architecture to construct gDNA and cDNA libraries.

    MICROFLUIDIC LARGE SCALE INTEGRATION
    7.
    发明专利
    MICROFLUIDIC LARGE SCALE INTEGRATION 未知

    公开(公告)号：AU2003282875A1

    公开(公告)日：2004-04-19

    申请号：AU2003282875

    申请日：2003-09-24

    Applicant: CALIFORNIA INST OF TECHN

    Inventor： THORSEN TODD A ,  BAO XIAOYAN ,  QUAKE STEPHEN R ,  STUDER VINCENT ,  MAERKL SEBASTIAN J

    IPC: B01L3/00 ,  F15C5/00 ,  F16K11/20 ,  F16K99/00 ,  B81B1/00

    Abstract: High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example devices for isolating elements of heterogeous samples.

    MICROFLUIDIC LARGE SCALE INTEGRATION
    8.
    发明专利
    MICROFLUIDIC LARGE SCALE INTEGRATION 未知

    公开(公告)号：SG145784A1

    公开(公告)日：2008-09-29

    申请号：SG2008064206

    申请日：2004-08-10

    Applicant: CALIFORNIA INST OF TECHN

    Inventor： STUDER VINCENT ,  QUAKE STEPHEN R ,  ANDERSON W FRENCH ,  MAERKL SEBASTIAN J

    IPC: F15C5/00

    Abstract: MICROFLUIDIC LARGE SCALE INTEGRATION Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.

    Microfluidic nucleic acid analysis
    9.
    发明专利
    Microfluidic nucleic acid analysis 未知

    公开(公告)号：AU2003299541A8

    公开(公告)日：2004-05-25

    申请号：AU2003299541

    申请日：2003-10-02

    Applicant: CALIFORNIA INST OF TECHN

    Inventor： QUAKE STEPHEN R ,  HONG JONG WOOK ,  LEADBETTER JARED ,  ANDERSON W FRENCH ,  STUDER VINCENT

    IPC: B01L3/00 ,  C12M1/34 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04 ,  C07H19/00

    Abstract: Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. Individual or small groups of cells or viruses may be isolated in microfluidic chambers by dilution, sorting, and/or segmentation. The isolated cells or viruses may be lysed directly in the microfluidic chamber, and the resulting nucleic acid purified by exposure to affinity beads. Subsequent elution of the purified nucleic acid may be followed by ligation and cell transformation, all within the same microfluidic chip. Cell isolation, lysis, and nucleic acid purification may be performed utilizing a highly parallelized microfluidic architecture to construct gDNA and cDNA libraries.

    MICROFLUIDIC LARGE SCALE INTEGRATION
    10.
    发明专利
    MICROFLUIDIC LARGE SCALE INTEGRATION 未知

    公开(公告)号：CA2535566A1

    公开(公告)日：2005-07-07

    申请号：CA2535566

    申请日：2004-08-10

    Applicant: CALIFORNIA INST OF TECHN

    Inventor： STUDER VINCENT ,  MAERKL SEBASTIAN J ,  ANDERSON W FRENCH ,  QUAKE STEPHEN R

    IPC: B01L3/02 ,  F15C3/04 ,  F15C5/00 ,  F16K7/17

    Abstract: Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing th e membranes to experience similar resistance to an applied pressure across the ir entire width. Such on-off valves fabricated with upwardly- or downwardly- deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both th e actuation pressure and flow resistance over a wide range of design parameter s, and comparing them to both finite element simulations and alternative valve geometries.

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