公开(公告)号：US11067575B2

公开(公告)日：2021-07-20

申请号：US16598433

申请日：2019-10-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552 ,  A61B5/1491

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US11026610B2

公开(公告)日：2021-06-08

申请号：US16144079

申请日：2018-09-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson Chen ,  Axel Scherer ,  Dvin Adalian ,  Peter Petillo ,  Muhammad Musab Jilani ,  Xiomara L. Madero ,  Deepan Kishore Kumar

IPC: C12N9/02 ,  C12N9/04 ,  C12N11/14 ,  A61B5/1486 ,  C12N11/02 ,  A61B5/145 ,  A61B5/1459 ,  G01N27/327

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

公开(公告)号：US10820844B2

公开(公告)日：2020-11-03

申请号：US15216662

申请日：2016-07-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Axel Scherer ,  Arti Gaur

IPC: G01N33/48 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/07 ,  A61B5/1486 ,  A61B17/34 ,  A61M5/142 ,  A61M5/172 ,  G06G7/58

Abstract: Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.

公开(公告)号：US10376892B2

公开(公告)日：2019-08-13

申请号：US15360691

申请日：2016-11-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Samson Chen ,  Axel Scherer ,  Christopher I. Walker

IPC: C12Q1/68 ,  B01L7/00 ,  H05K3/46 ,  B01L3/00 ,  H05K1/02 ,  C12Q1/686

Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.

公开(公告)号：US20190170637A1

公开(公告)日：2019-06-06

申请号：US16212499

申请日：2018-12-06

Applicant: California Institute of Technology

Inventor： Axel Scherer ,  Amirhossein Nateghi ,  Taeyoon Jeon

IPC: G01N21/25 ,  G01N21/35 ,  G01N1/44 ,  G01N1/42 ,  G01N21/17

Abstract: The present disclosure is directed toward a measurement system capable of rapid spectroscopic and calorimetric analysis of the chemical makeup of a test sample. Systems in accordance with the present disclosure include a low-thermal-mass sample holder having a substrate whose surface has been engineered to create a large-area sample-collection surface. The sample holder includes an integrated temperature controller that can rapidly heat or cool the test sample. As a result, the sample holder enables differential scanning calorimetry Fourier-Transform Infrared Spectroscopy (DSC-FTIR) that can be performed in minutes rather than hours, as required in the prior art.

公开(公告)号：US10068051B2

公开(公告)日：2018-09-04

申请号：US14451876

申请日：2014-08-05

Applicant: California Institute of Technology

Inventor： Emil Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G01N33/48 ,  G01N33/50 ,  G06F19/20 ,  G06F19/12 ,  C12Q1/68 ,  G01N21/64 ,  C12Q1/6825 ,  C12Q1/6851 ,  G06F19/24 ,  G06F17/10 ,  G06F17/11

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US09987609B2

公开(公告)日：2018-06-05

申请号：US14621306

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Sameer Walavalkar ,  Axel Scherer

IPC: B01J19/00 ,  G01N21/65 ,  C12Q1/68

CPC classification number: B01J19/0046 ,  B01J2219/00585 ,  C12Q1/689 ,  C12Q2600/158 ,  G01N21/65 ,  G01N21/658

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

公开(公告)号：US20170074786A1

公开(公告)日：2017-03-16

申请号：US15359296

申请日：2016-11-22

Applicant: California Institute of Technology

Inventor： Axel Scherer ,  Frank T. Hartley

IPC: G01N21/35

CPC classification number: G01N21/35 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/18 ,  G01J3/36 ,  G01J3/42 ,  G01J2003/1213 ,  G01N21/3577

Abstract: MIR spectroscopy systems comprising hierarchical spectral dispersion that enables fine spectral resolution and high sensitivity spectroscopy are disclosed. Hierarchical spectral dispersion is derived by employing at least two diffractive lens arrays, located on either side of a test sample, each receiving input radiation having an input spectral range and distributing the input radiation into a plurality of output signals, each having a fraction of the spectral range of the input radiation. As a result, the signal multiplication factor of the two arrays is multiplied in a manner that mitigates the propagation of wavelength harmonics through the system. In some embodiments, an emitter array comprising a plurality of spectrally selective emitters provides the input MIR radiation to a spectroscopy system. In some embodiments, spectrally selective detectors are used to detect narrow spectral components in the radiation after they have passed through the test sample.

Abstract translation: 公开了包括能够进行精细光谱分辨率和高灵敏度光谱的分级光谱色散的MIR光谱系统。 通过采用位于测试样本两侧的至少两个衍射透镜阵列来导出分层光谱色散，每个衍射透镜阵列接收具有输入光谱范围的输入辐射并将输入辐射分配成多个输出信号，每个输出信号具有 输入辐射的光谱范围。 结果，两个阵列的信号乘法因子以减轻波长谐波通过系统的传播的方式相乘。 在一些实施例中，包括多个光谱选择性发射器的发射器阵列将输入MIR辐射提供给光谱系统。 在一些实施例中，光谱选择性检测器用于在它们通过测试样品之后检测辐射中的窄光谱分量。

公开(公告)号：US09533308B2

公开(公告)日：2017-01-03

申请号：US13763352

申请日：2013-02-08

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Samson Chen ,  Axel Scherer ,  Christopher I. Walker

IPC: B01L7/00 ,  H05K3/46 ,  B01L3/00 ,  C12Q1/68 ,  H05K1/02

CPC classification number: B01L7/52 ,  B01L3/502707 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686 ,  H05K1/0212 ,  H05K1/0272 ,  H05K1/028 ,  H05K3/46 ,  H05K3/4697 ,  Y10T29/49124

Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.

Abstract translation: 公开了一种用于进行聚合酶链式反应（PCR）的装置。 该装置包括用于进行聚合酶链式反应的PCR室和印刷电路板（PCB）流体装置。 PCR室是流体室，并且位于印刷电路板（PCB）流体装置中或者是其中的一部分。 进一步公开了进行聚合酶链式反应的装置的制造方法和进行聚合酶链式反应的方法。

公开(公告)号：US09390936B2

公开(公告)日：2016-07-12

申请号：US14527039

申请日：2014-10-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  Stephanie Tombrello

Inventor： Michael D. Henry ,  Andrew P. Homyk ,  Axel Scherer ,  Thomas A. Tombrello ,  Sameer Walavalkar

IPC: G01N1/18 ,  H01L21/308 ,  B81C1/00 ,  H01L21/3065 ,  G01N1/40

CPC classification number: B81C1/00111 ,  B01J19/0046 ,  B01J2219/00504 ,  B01J2219/00664 ,  B81B1/006 ,  B81B2203/0361 ,  B81B2207/056 ,  B81C2201/0112 ,  B81C2201/0132 ,  B81C2201/0133 ,  B81C2201/0159 ,  G01N1/405 ,  H01L21/3065 ,  H01L21/30655 ,  H01L21/3081 ,  H01L21/3086 ,  Y10T436/25375

Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.