公开(公告)号：AU539107B2

公开(公告)日：1984-09-13

申请号：AU5423579

申请日：1979-12-28

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D498/04

Abstract: The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin- 9-one is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chlorosalicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.

公开(公告)号：NO833071L

公开(公告)日：1983-08-26

申请号：NO833071

申请日：1983-08-26

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  C07D

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：FI833016A0

公开(公告)日：1983-08-23

申请号：FI833016

申请日：1983-08-23

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13 ,  C07D

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

公开(公告)号：NO794289L

公开(公告)日：1980-07-01

申请号：NO794289

申请日：1979-12-27

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07D498/04 ,  C07D

Abstract: The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin- 9-one is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chlorosalicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.

公开(公告)号：IT7968887D0

公开(公告)日：1979-09-28

申请号：IT6888779

申请日：1979-09-28

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C29/17 ,  C07C29/38 ,  C07C43/15 ,  C07C45/51 ,  C07C47/21 ,  C07C

Abstract: A process for the production of 2-methyl-2-sec. butyl-1,3-propanediol from crotyl alcohol is disclosed. The diol obtained is useful in the manufacture of 2-methyl-2-(1-methylpropyl)-1,3-propanediol dicarbamate a valuable antihypertensive agent.

公开(公告)号：US3428638A

公开(公告)日：1969-02-18

申请号：US3428638D

申请日：1967-02-10

Applicant: CARTER WALLACE

Inventor： DILLE JAMES M ,  STIEFEL FRANK J ,  MEYER MERVIN

IPC: C07D239/54 ,  C07D239/545 ,  C07D5/22 ,  A61K27/00

CPC classification number: C07D239/545

公开(公告)号：US3400125A

公开(公告)日：1968-09-03

申请号：US52513166

申请日：1966-02-04

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J ,  LUDWIG BERNARD J ,  BERGER FRANK M

IPC: C07D473/24 ,  C07D473/38

CPC classification number: C07D473/38 ,  C07D473/24

公开(公告)号：NO940113A

公开(公告)日：1994-03-11

申请号：NO940113

申请日：1994-01-12

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: B01J23/44 ,  B01J27/232 ,  C07B61/00 ,  C07C20060101 ,  C07C29/00 ,  C07C29/132 ,  C07C33/26 ,  C07C201/10 ,  C07C201/12 ,  C07C205/04 ,  C07C205/16

CPC classification number: C07C33/26 ,  C07C29/00 ,  C07C201/06 ,  C07C201/12 ,  C07C205/04 ,  C07C205/16

公开(公告)号：DE68907596D1

公开(公告)日：1993-08-19

申请号：DE68907596

申请日：1989-08-15

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: C07C29/00 ,  C07C33/26 ,  C07C201/12 ,  C07C205/04 ,  C07C271/10

公开(公告)号：NO158059B

公开(公告)日：1988-03-28

申请号：NO833071

申请日：1983-08-26

Applicant: CARTER WALLACE

Inventor： STIEFEL FRANK J

IPC: A61K31/40 ,  C07D295/08 ,  A61P9/08 ,  A61P9/10 ,  C07D20060101 ,  C07D207/00 ,  C07D295/088 ,  C07D295/12 ,  C07D295/13

Abstract: A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.