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公开(公告)号：CA2795177A1
公开(公告)日：2011-10-06
申请号：CA2795177
申请日：2011-04-01
Applicant: CYTOSORBENTS CORP
Inventor： CHAN PHILLIP P , YOUNG WEI-TAI , CAPPONI VINCENT J , GOLOBISH THOMAS D , BARLETT ROBERT H
IPC: A61K31/74 , A61K31/717 , A61P29/00
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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12.发明专利
公开(公告)号：AU2021273537A1
公开(公告)日：2021-12-16
申请号：AU2021273537
申请日：2021-11-23
Applicant: CYTOSORBENTS CORP
Inventor： GULIASHVILI TAMAZ , GOLOBISH THOMAS , GRUDA MARYANN , O'SULLIVAN PAMELA , SCHEIRER ANDREW , CAPPONI VINCENT , CHAN PHILLIP , YOUNG WEI-TAI
Abstract: Abstract The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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公开(公告)号：AU2016342263B2
公开(公告)日：2021-07-22
申请号：AU2016342263
申请日：2016-10-21
Applicant: CYTOSORBENTS CORP
Inventor： GOLOBISH THOMAS , GRUDA MARYANN , GULIASHVILI TAMAZ , O'SULLIVAN PAMELA , SCHEIRER ANDREW , DAN VI , YOUNG WEI-TAI , CAPPONI VINCENT , CHAN PHILLIP
IPC: A61M5/165 , A61K31/795 , A61K47/20 , A61M1/34
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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公开(公告)号：CA3072367A1
公开(公告)日：2019-03-21
申请号：CA3072367
申请日：2018-09-13
Applicant: CYTOSORBENTS CORP
Inventor： GUTZLER DOMINIK , YOUNG WEI-TAI
IPC: A61M1/14
Abstract: Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, a second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.
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公开(公告)号：CA3057632A1
公开(公告)日：2018-10-04
申请号：CA3057632
申请日：2018-03-22
Applicant: CYTOSORBENTS CORP
Inventor： YOUNG WEI-TAI , GULIASHVILI TAMAZ , SCHEIRER ANDREW , VICHARE JOSH , KOVACS TIMOTHY , GRUDA MARYANN , GOLOBISH THOMAS , CAPPONI VINCENT , CHAN PHILLIP
Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
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Patent Agency Ranking
公开(公告)号：MX342421B
公开(公告)日：2016-09-28
申请号：MX2012011305
申请日：2011-04-01
Applicant: CYTOSORBENTS CORP *
Inventor： CHAN PHILLIP P , YOUNG WEI-TAI , CAPPONI VINCENT J , GOLOBISH THOMAS D , BARTLETT ROBERT H , HUMAYRA BEGUM ALI
Abstract: La presente invención es concerniente con métodos de tratamiento de inflamación sistémica, regional o local de un paciente que sufre o está en riesgo de inflamación que comprende la administración de una dosis terapéuticamente efectiva de un sorbente que absorbe un mediador inflamatorio en dicho paciente. En algunas modalidades preferidas, el sorbente es un polímero orgánico biocompartible.
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公开(公告)号：AU2018246007C1
公开(公告)日：2022-06-23
申请号：AU2018246007
申请日：2018-03-22
Applicant: CYTOSORBENTS CORP
Inventor： YOUNG WEI-TAI , GULIASHVILI TAMAZ , SCHEIRER ANDREW , VICHARE JOSH , KOVACS TIMOTHY , GRUDA MARYANN , GOLOBISH THOMAS , CAPPONI VINCENT , CHAN PHILLIP
Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
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公开(公告)号：AU2018246007B2
公开(公告)日：2022-03-17
申请号：AU2018246007
申请日：2018-03-22
Applicant: CYTOSORBENTS CORP
Inventor： YOUNG WEI-TAI , GULIASHVILI TAMAZ , SCHEIRER ANDREW , VICHARE JOSH , KOVACS TIMOTHY , GRUDA MARYANN , GOLOBISH THOMAS , CAPPONI VINCENT , CHAN PHILLIP
Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
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19.发明专利
公开(公告)号：AU2017272021B2
公开(公告)日：2021-09-02
申请号：AU2017272021
申请日：2017-05-18
Applicant: CYTOSORBENTS CORP
Inventor： GULIASHVILI TAMAZ , GOLOBISH THOMAS , GRUDA MARYANN , O'SULLIVAN PAMELA , SCHEIRER ANDREW , CAPPONI VINCENT , CHAN PHILLIP , YOUNG WEI-TAI
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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20.发明专利
公开(公告)号：AU2017272021A1
公开(公告)日：2018-11-29
申请号：AU2017272021
申请日：2017-05-18
Applicant: CYTOSORBENTS CORP
Inventor： GULIASHVILI TAMAZ , GOLOBISH THOMAS , GRUDA MARYANN , O'SULLIVAN PAMELA , SCHEIRER ANDREW , CAPPONI VINCENT , CHAN PHILLIP , YOUNG WEI-TAI
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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