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    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION
    11.
    发明申请
    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 审中-公开
    系统，方法和计算机可访问介质，提供特定解决方案中至少一个解剖结构的微观图像

    公开(公告)号：WO2011109828A2

    公开(公告)日：2011-09-09

    申请号：PCT/US2011027437

    申请日：2011-03-07

    Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

    Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

    CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

    Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.

    Abstract translation: 可以提供可以生成与样品的至少一部分相关联的数据的系统和方法的示例性实施例。 例如，可以通过至少一个光学布置将至少一个第一辐射转发到该部分。 可以从基于第一辐射的部分接收至少一个第二辐射。 基于光学布置和第一辐射和/或第二辐射之间的相互作用，光学装置可以具有第一传递函数。 此外，可以通过这种光学装置（或通过另一种光学装置）将至少一个第三辐射转发到该部分，并且从基于第三辐射的部分接收至少一个第四辐射。 基于光学布置（或另一个光学布置）与第三辐射和/或第四辐射之间的相互作用，光学布置（或另一个光学布置）可以具有第二传递函数。 第一传递函数可以至少部分地不同于第二传递函数。 可以基于第二和第四辐射来生成数据。

    SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING
    14.
    发明申请
    SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING 审中-公开
    通过路径长度编码角度化合物进行光学相干光谱中的光谱减少

    公开(公告)号：WO2004088361A2

    公开(公告)日：2004-10-14

    申请号：PCT/US2004010152

    申请日：2004-03-31

    Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  IFTIMIA NICUSOR ,  BOUMA BRETT E

    Inventor： TEARNEY GUILLERMO J ,  IFTIMIA NICUSOR ,  BOUMA BRETT E

    IPC: A61B5/00 ,  G01J9/02 ,  G01N21/47 ,  G02B27/48 ,  G02B

    CPC classification number: A61B5/0066 ,  A61B5/0059 ,  A61B5/6852 ,  G01B9/02028 ,  G01B9/02082 ,  G01B9/02087 ,  G01B9/02091 ,  G01J9/0215 ,  G01N21/4795 ,  G02B26/105 ,  G02B27/48

    Abstract: Speckle, a factor reducing image quality in optical coherence tomography ("OCT"), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. The present invention allows for an implementation of an angular compounding, angular compounding by path length encoding ("ACPE") for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio ("SNR"). Accordingly, apparatus probe catheter, and method are provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the sample. Such arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

    Abstract translation: 斑点，减少光学相干断层扫描（“OCT”）中的图像质量的因素可能会限制识别对各种疾病的诊断重要的细胞结构的能力。 本发明允许通过路径长度编码（“ACPE”）实现角复合角度复合，以减少OCT图像中的斑点。 通过平均以不同入射角度获取的图像，每个图像由路径长度编码，ACPE保持高速图像采集，并对OCT探针光学元件进行最小修改。 从体内组织模型和人体皮肤获得的ACPE图像显示出比传统OCT和增加的信噪比（“SNR”）的定性改善。 因此，提供了用于照射样品的装置探针导管和方法。 具体地，干涉仪可以转发电磁辐射。 此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射样品的装置。 这种布置可以被配置为相对于至少两个辐射的第二辐射延迟至少两个辐射的第一辐射。

    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION
    15.
    发明公开
    SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 审中-公开
    系统，方法和每台计算机可访问介质，用于提供显微图像最不解剖结构与特定的解决方案

    公开(公告)号：EP2542145A4

    公开(公告)日：2014-07-02

    申请号：EP11751514

    申请日：2011-03-07

    Applicant: GEN HOSPITAL CORP

    Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

    IPC: A61B5/00 ,  G01B9/02

    CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

    Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.

    SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING
    16.
    发明公开
    SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING 有权
    散斑减少BEI光学相干断层BYWEGLÄNGENCODIERTEANGLE COMPOSITION

    公开(公告)号：EP1611470A4

    公开(公告)日：2009-06-17

    申请号：EP04749658

    申请日：2004-03-31

    Applicant: GEN HOSPITAL CORP

    Inventor： TEARNEY GUILLERMO J ,  IFTIMIA NICUSOR ,  BOUMA BRETT E

    IPC: G02B9/02 ,  A61B5/00 ,  G01J9/02 ,  G01N21/47 ,  G02B27/48

    CPC classification number: A61B5/0066 ,  A61B5/0059 ,  A61B5/6852 ,  G01B9/02028 ,  G01B9/02082 ,  G01B9/02087 ,  G01B9/02091 ,  G01J9/0215 ,  G01N21/4795 ,  G02B26/105 ,  G02B27/48

    Abstract: Speckle, a factor reducing image quality in optical coherence tomography ('OCT'), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. The present invention allows for an implementation of an angular compounding, angular compounding by path length encoding ('ACPE') for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio ('SNR'). Accordingly, apparatus probe catheter, and method are provided for irradiating a sample. In particular, an interferometer (5) may forward forwarding an electromagnetic radiation (10). In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement (20) which facilitates a production of at least two radiations (30, 40) from the electromagnetic radiation so as to irradiate the sample. Such arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

    ENDOSCOPIC BIOPSY APPARATUS, SYSTEM AND METHOD
    19.
    发明公开
    ENDOSCOPIC BIOPSY APPARATUS, SYSTEM AND METHOD 审中-公开
    内镜活检设备及相应的系统和方法

    公开(公告)号：EP2389093A4

    公开(公告)日：2013-07-31

    申请号：EP10738929

    申请日：2010-01-20

    Applicant: GEN HOSPITAL CORP

    Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  SUTER MELISSA J

    IPC: A61B1/04

    CPC classification number: A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0086

    Abstract: Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.

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