公开(公告)号：WO2011109818A3

公开(公告)日：2012-01-12

申请号：PCT/US2011027421

申请日：2011-03-07

Applicant: GEN HOSPITAL CORP ,  UNIV COLORADO ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO ,  MCLEOD ROBERT R

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO ,  MCLEOD ROBERT R

IPC: A61B5/05 ,  A61B5/02

CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

Abstract: Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.

Abstract translation: 可以提供装置，系统和方法的示例性实施例，以向至少一个样品提供至少一个电磁辐射。 例如，可以提供多个波导装置，其被配置为（i）提供电磁辐射，和（ii）在每个波导装置的发射点处，引起相位 每个电磁辐射具有预定值。 示例性装置可以是探针的一部分。 此外，示例性装置可以包括与探针连接和/或成为探针的一部分提供的干涉装置。

公开(公告)号：WO2010068764A3

公开(公告)日：2010-08-19

申请号：PCT/US2009067512

申请日：2009-12-10

Applicant: GEN HOSPITAL CORP ,  VAKOC BENJAMIN J ,  OH WANG Y ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E

Inventor： VAKOC BENJAMIN J ,  OH WANG Y ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E

IPC: G01N21/17 ,  G01B9/02 ,  G01N21/47 ,  G01N33/483

CPC classification number: A61B5/6852 ,  A61B5/0066

Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

Abstract translation: 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样本，以便从样本提供至少一个第二辐射，该第二辐射可以基于 第一辐射。 另外，使用至少一个第二布置，可以接收来自样本的第二辐射，基于第二辐射产生关于样本的至少一部分的多个不同测量值， 并且在与不同测量相关联的多个连续可分辨深度点上表征该部分。 此外，至少一部分的表征可以在大于不同测量的数量的多个深度点处被解析和明确表征。

公开(公告)号：WO2007084995A3

公开(公告)日：2008-07-03

申请号：PCT/US2007060787

申请日：2007-01-19

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  NISHIOKA NORMAN S

Inventor： TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  NISHIOKA NORMAN S

IPC: A61B5/00 ,  A61B1/07

CPC classification number: A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

Abstract: Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

Abstract translation: 提供了布置，装置，系统和系统以获得至少一个管腔或空心样品中的至少一部分的数据。 该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见） 第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是 被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置 其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

公开(公告)号：WO2007149603A2

公开(公告)日：2007-12-27

申请号：PCT/US2007061481

申请日：2007-02-01

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J

Inventor： TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E ,  VAKOC BENJAMIN J

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

Abstract: An apparatus for applying a plurality of electro-magnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.

Abstract translation: 提供了一种向样品施加多个电磁辐射的装置。 在一个示例性实施例中，装置可以包括具有多个通道的特定部分的装置。 通道中的一个可以促进要转发到解剖结构内的样品的辐射的第一辐射，并且另一个通道可以促进辐射的第二次辐射以被转发到样品。 第一辐射可以具有第一波长带，并且第二辐射可以具有第二波长带。 第一波长带可能与第二波长带显着不同。 根据另一示例性实施例，第一辐射可以适于被传送到样品的第一区域，并且第二辐射可以能够被传送到样品的第二区域。 第一区域可以基本上被第二区域包围。 根据本发明的另一示例性实施例，每个通道可以促进要转发到样品的解剖结构内的样品的辐射的至少一个特定辐射，辐射被递送到样品的解剖结构内 样品。 可以基本沿着一条线提供每个区域的中心。

公开(公告)号：WO2011008822A2

公开(公告)日：2011-01-20

申请号：PCT/US2010041923

申请日：2010-07-14

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SUTER MELISSA ,  BOUMA BRETT E ,  JAFFER FAROUC A

Inventor： TEARNEY GUILLERMO J ,  SUTER MELISSA ,  BOUMA BRETT E ,  JAFFER FAROUC A

IPC: A61B5/021 ,  A61B5/02 ,  A61B5/027

CPC classification number: A61B5/0261 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/024

Abstract: Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference.

Abstract translation: 可以提供设备，系统和方法的示例性实施例以测量解剖结构内的流体流量。 例如，可以使用至少一个第一探针装置，所述第一探针装置被构造成可插入脉管并被配置为将至少一个辐射引导至解剖结构的至少一部分。 此外，可以提供至少一个第二布置，其被配置为检测从流体经由探针布置提供的第一辐射与从参考路径提供的第二辐射之间的干涉作为其波长的函数。 此外，可以提供至少一个第三布置，其被配置为根据干涉来确定流体的至少一个特性。

公开(公告)号：WO2010090837A3

公开(公告)日：2010-11-18

申请号：PCT/US2010021514

申请日：2010-01-20

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  SUTER MELISSA J

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  SUTER MELISSA J

IPC: A61B1/04

CPC classification number: A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0086

Abstract: Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.

Abstract translation: 可以提供用于确定生物组织上或生物组织中的位置的设备，方法和系统的示例性实施例。 例如，使用这样的示例性实施例，可以控制光学成像探头的焦点。 在另一个示例性实施例中，可以将标记设备与光学成像探针一起或者引入光学成像探针中。 根据一个示例性实施例，可以（使用一个或多个布置）接收与使用光学成像技术获得的生物组织的至少一部分的至少一个图像相关联的信息。 此外，基于所述信息，可以使用至少一个电磁辐射在所述部分的至少位置上或其中引起可见变化。

公开(公告)号：WO2009137701A2

公开(公告)日：2009-11-12

申请号：PCT/US2009043178

申请日：2009-05-07

Applicant: GEN HOSPITAL CORP ,  COLICE CHRISTOPHER MAX ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J ,  HA JINYONG ,  SHISHKOV MILEN

Inventor： COLICE CHRISTOPHER MAX ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J ,  HA JINYONG ,  SHISHKOV MILEN

IPC: G01B11/24 ,  G01B7/28 ,  G01B11/25 ,  G01B17/06 ,  G01P3/00 ,  G06F17/00

CPC classification number: A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0097 ,  A61B5/1076 ,  A61B5/1114 ,  A61B5/489 ,  A61B5/6844 ,  A61B5/6852 ,  A61B8/08 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/488 ,  A61B90/36 ,  A61B2090/364 ,  A61B2090/3782 ,  G01S15/50 ,  G01S15/60 ,  G01S15/87 ,  G01S17/50 ,  G01S17/87

Abstract: Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes.

Abstract translation: 可以提供装置，方法和计算机可访问介质的示例性实施例，其可以有助于确定结构的至少一个特征。 例如，可以使用至少一个第一布置，其可被构造成沿着第一轴线提供至少一个第一透射辐射以及沿着第二轴线提供至少一个第二透射辐射。 第一和第二透射辐射可以影响结构并产生相应的第一和第二反射辐射。 第一和第二轴线可以彼此相对于预定角度提供，该角度大于0.此外，可以提供至少一个第二布置，其可被配置为接收与第一和第二返回辐射有关的数据，以及 确定沿着第一和第二轴线的结构和第一布置之间的至少一个相对速度。

公开(公告)号：WO2004065994A3

公开(公告)日：2004-12-23

申请号：PCT/US2004001499

申请日：2004-01-21

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  PITRIS CONSTANTINOS ,  SHISHKOV MILEN ,  BOUMA BRETT E

Inventor： TEARNEY GUILLERMO J ,  PITRIS CONSTANTINOS ,  SHISHKOV MILEN ,  BOUMA BRETT E

IPC: G02B21/00 ,  G02B21/02 ,  G02B21/33 ,  A16B1/06 ,  A16B6/00

CPC classification number: G02B21/0072 ,  G02B21/006 ,  G02B21/02 ,  G02B21/33

Abstract: A confocal microscope lens arrangement is provided. The confocal microscope lens arrangement includes a lens assembly housing which has a lens assembly, and an exterior housing including a distal end and a proximal end. The exterior housing is configured to allow the lens assembly housing to be placed therein, and translated between the proximal end and the distal end of the exterior housing to focus the lens assembly. The exterior housing has an aperture formed through a distal end thereof. The arrangement also includes an immersion media filling the volume of area between the exterior housing and the lens assembly housing.

Abstract translation: 提供共聚焦显微镜镜头布置。 共聚焦显微镜透镜装置包括具有透镜组件的透镜组件外壳以及包括远端和近端的外壳。 外部壳体被构造成允许透镜组件壳体放置在其中并且在外部壳体的近端和远端之间平移以聚焦透镜组件。 外壳具有穿过其远端形成的孔。 该装置还包括填充外部壳体和透镜组件壳体之间的区域的体积的浸没介质。

公开(公告)号：WO2012058441A2

公开(公告)日：2012-05-03

申请号：PCT/US2011058110

申请日：2011-10-27

Applicant: GEN HOSPITAL CORP ,  WARGER WILLIAM C II ,  HANCOCK JAMES L ,  GARDECKI JOSEPH ,  SUTER MELISSA ,  VELMAHOS GEORGE ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J

Inventor： WARGER WILLIAM C II ,  HANCOCK JAMES L ,  GARDECKI JOSEPH ,  SUTER MELISSA ,  VELMAHOS GEORGE ,  BOUMA BRETT E ,  TEARNEY GUILLERMO J

IPC: A61B5/05 ,  A61B1/267

CPC classification number: A61B1/267 ,  A61B1/00043 ,  A61B5/4887 ,  A61B5/489

Abstract: Exemplary apparatus and method for determining information regarding at least one anatomical structure can be provided. For example, it is possible to forward at least one first optical electro-magnetic radiation to the at least one structure (e.g., using at least one first arrangement), and detect at least one second electro-magnetic radiation provided from the at least one structure which is based on first electro-magnetic radiation(s) (e.g., using and at least one second arrangement). It is also possible to determine at least one characteristic of the structure(s) inside thereof based on the second electro-magnetic radiation (e.g., using and at least one third arrangement). For example, the characteristic(s) can include an identification of the structure(s) upon a placement of an apparatus performing such procedure(s) at, within or near at least one airway portion of the structure(s).

Abstract translation: 可以提供用于确定关于至少一个解剖结构的信息的示例性装置和方法。 例如，可以将至少一个第一光电磁辐射转发到至少一个结构（例如，使用至少一个第一布置），并且检测从至少一个第二电磁辐射提供的至少一个第二电磁辐射 基于第一电磁辐射（例如，使用和至少一个第二布置）的结构。 还可以基于第二电磁辐射（例如，使用至少一个第三布置）来确定其内部结构的至少一个特征。 例如，（一个或多个）特征可以包括在执行这样的过程的装置放置在结构的至少一个气道部分处，之内或附近时识别结构。

公开(公告)号：WO2011150069A3

公开(公告)日：2012-02-23

申请号：PCT/US2011037916

申请日：2011-05-25

Applicant: GEN HOSPITAL CORP ,  FLEMING CHRISTINE ,  BOUMA BRETT E ,  GARDECKI JOSEPH ,  TEARNEY GUILLERMO J

Inventor： FLEMING CHRISTINE ,  BOUMA BRETT E ,  GARDECKI JOSEPH ,  TEARNEY GUILLERMO J

IPC: A61B5/00 ,  G01B9/02 ,  G01N21/17

CPC classification number: A61B5/0066 ,  A61B5/02007 ,  A61B5/7264 ,  G01B9/02091 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2201/129 ,  G01N2201/1293

Abstract: According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation. Further, with at least one second arrangement, it is possible to generate spectroscopic data as a function of the at least one third radiation, and reduce at least one scattering effect in the spectroscopic data to generate the information. In addition or as an alternative, according to a further exemplary embodiment of the present disclosure, it is possible to classify a type of the structure based on the spectroscopic data to generate the information.

Abstract translation: 根据本公开的示例性实施例，可以提供装置和方法来产生用于至少一个结构的信息。 例如，使用至少一个第一布置，可以接收来自至少一个结构的至少一个第一辐射和来自参考的至少一个第二辐射，并且干扰第一和第二辐射以产生至少一个第三辐射 。 此外，利用至少一个第二布置，可以产生作为至少一个第三辐射的函数的光谱数据，并且减少光谱数据中的至少一个散射效应以产生信息。 另外或作为替代，根据本公开的另一示例性实施例，可以基于光谱数据对类型的结构进行分类以生成信息。