公开(公告)号：PL322778A1

公开(公告)日：1998-02-16

申请号：PL32277896

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14

Abstract: Metered dose inhaler having all or part of its internal surfaces coated with one or more fluorocarbon polymers, opt. in combination with one or more non-fluorocarbon polymers, is used for dispensing an inhalation drug formulation comprising albuterol (also known as salbutamol) or one of its salts, and a fluorocarbon propellant, opt. in combination with one or more other pharmacologically active agents or one or more excipients. Also claimed is a metered dose inhaler system comprising a metered dose inhaler fitted into a suitable channelling device for oral or nasal inhalation of the drug formulation.

公开(公告)号：BG101347A

公开(公告)日：1997-12-30

申请号：BG10134797

申请日：1997-03-21

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH A

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: The pharmaceutical aerosol composition consists of amedicamentous composition in the form of particles, hydrogenfluoride propellent or hydrogen-containing chloro hydrogenfluoride propellent and a surfactant having the general formulawhere n is factor having the value from 1 to 18; m is a factorhaving the value from 0 to 17, and R1, R2 and R3 separately meanhydrogen stom or C1-4 alkyl group.

公开(公告)号：MX9707878A

公开(公告)日：1997-11-29

申请号：MX9707878

申请日：1996-04-11

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14 ,  A61K09/00 ,  B05D05/08

Abstract: La presente invencion se refiere a un inhalador de dosis medida, que tiene todas las superficies internas, o parte de las mismas, recubiertas con uno o más polímeros de fluorocarburos, opcionalmente en combinacion con uno o más polímeros que no son fluorocarburos, para el suministro de una formulacion de fármaco para inhalacion, que comprende dipropionato de beclometasona o un solvato fisiologicamente aceptable del mismo, y un propulsor o impelente a base de fluorocarburo, opcionalmente en combinacion con uno o más de otros agentes farmacologicamente activos, o uno o más excipientes.

公开(公告)号：MX9707864A

公开(公告)日：1997-11-29

申请号：MX9707864

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14 ,  B05D05/08

Abstract: Un inhalador de dosis medida que tiene parte o el total de sus superficies internas revestidas con uno o más polímeros de fluorocarburo, opcionalmente en combinacion con uno o más polímeros sin fluorocarburo, para distribuir una formulacion del fármaco para inhalacion que comprende salmeterol o una sal del mismo fisiologicamente aceptable, y un propulsor de fluorocarburo, opcionalmente en combinacion con uno o más de otros agentes farmacologicamente activos y uno o más excipientes.

公开(公告)号：NO971422L

公开(公告)日：1997-05-23

申请号：NO971422

申请日：1997-03-25

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：FI971279A

公开(公告)日：1997-03-26

申请号：FI971279

申请日：1997-03-26

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20 ,  A61K

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：CA2218179A1

公开(公告)日：1996-10-17

申请号：CA2218179

申请日：1996-04-11

Applicant: GLAXO WELLCOME INC

Inventor： HERMAN CRAIG S ,  ASHURST IAN C ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14 ,  B65D83/54

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：CY2401B1

公开(公告)日：2004-09-10

申请号：CY0400001

申请日：2004-01-02

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：BG64117B1

公开(公告)日：2004-01-30

申请号：BG10202297

申请日：1997-11-05

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14

Abstract: The inhaler is used for metering of inhalation medicamentous compositions including salmetrol or its physiologically acceptable salt and hydrogen fluoride propellant, optionally in combination with one or more other pharmacologically active substances and one or more fillers. It has partially or completely covered inner surfaces with one or more hydrogen fluoride polymers, optionally in combination with one or more non hydrogen fluoride polymers. 21 claims

公开(公告)号：BG64039B1

公开(公告)日：2003-11-28

申请号：BG10197297

申请日：1997-10-15

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

Abstract: The dosage fixing inhaler has partial or fully covered internal surfaces coated by one or more fluorocarbon polymers, optionally in combination with one or more nonfluorocarbon polymers. It is applied for the dispersion of medicamentous forms for inhalations consisting of fluticazon propionate or its physiologically acceptable solution and optionallyin fluorcarbon propellent combination with one or more pharmacologically active agents and one or more additional substances. 22 claims