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公开(公告)号:CA2200986C
公开(公告)日:2007-03-06
申请号:CA2200986
申请日:1995-09-27
Applicant: GLAXO WELLCOME INC
Inventor: JOHNSON KEITH ARTHUR , LI-BOVET LI
IPC: A61K9/12 , A61K9/00 , A61K9/72 , A61K31/137 , A61K31/56 , A61K31/66 , A61K47/06 , C07F9/09 , C07F9/10 , C09K23/20
Abstract: A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluoro-carbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.
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公开(公告)号:OA10603A
公开(公告)日:2002-08-30
申请号:OA60982
申请日:1997-03-21
Applicant: GLAXO WELLCOME INC
Inventor: LI-BOVET LI , JOHNSON KEITH ARTHUR
Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.
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公开(公告)号:OA10625A
公开(公告)日:2001-04-24
申请号:OA70103
申请日:1997-10-10
Applicant: GLAXO WELLCOME INC
Inventor: ASHURST IAN C , HERMAN CRAIG S , LI-BOVET LI , RIEBE MICHAEL T
IPC: B65D83/38 , A61K9/00 , A61K9/12 , A61K9/72 , A61K31/137 , A61K31/57 , A61K31/573 , A61M15/00 , A61P11/00 , B05D5/08 , B65D83/14
Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.
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公开(公告)号:GR3032245T3
公开(公告)日:2000-04-27
申请号:GR990403333
申请日:1999-12-22
Applicant: GLAXO WELLCOME INC
Inventor: LI-BOVET LI , JOHNSON KEITH ARTHUR
Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.
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公开(公告)号:CZ286356B6
公开(公告)日:2000-03-15
申请号:CZ93697
申请日:1995-09-27
Applicant: GLAXO WELLCOME INC
Inventor: LI-BOVET LI , JOHNSON KEITH ARTHUR
Abstract: In the present invention there is disclosed a pharmaceutical in the form of aerosol containing an active substance in particulate form being represented by fluorinated hydrocarbon or chlorinated and fluorinated hydrocarbon, further containing hydrogen atoms as a driving means and wetting agents of the general formulas Ia, and Ib in which the individual symbols have specific meanings. The invented pharmaceutical preparation is intended for inhaling into lungs or into nasal cavity.
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公开(公告)号:DE69513671D1
公开(公告)日:2000-01-05
申请号:DE69513671
申请日:1995-09-27
Applicant: GLAXO WELLCOME INC
Inventor: LI-BOVET LI , JOHNSON KEITH
Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.
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公开(公告)号:AT187063T
公开(公告)日:1999-12-15
申请号:AT95932166
申请日:1995-09-27
Applicant: GLAXO WELLCOME INC
Inventor: LI-BOVET LI , JOHNSON KEITH ARTHUR
Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.
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公开(公告)号:BG102023A
公开(公告)日:1998-07-31
申请号:BG10202397
申请日:1997-11-05
Applicant: GLAXO WELLCOME INC
Inventor: ASHURST IAN C , HERMAN CRAIG S , LI-BOVET LI , RIEBE MICHAEL T
IPC: B65D83/38 , A61K9/00 , A61K9/12 , A61K9/72 , A61K31/137 , A61K31/57 , A61K31/573 , A61M15/00 , A61P11/00 , B05D5/08 , B65D83/14
Abstract: A metered dose inhaler having part or all of its internalsurfaces coated with one or mom fluorocarbon polymers, optionallyin combination with one or more non-fluorocarbon polymers, fordispensing an inhalation drug formulation comprisingbeclomethasone dipropionate or a physiologically acceptablesolvate thereof, and a fluorocarbon propellant, optionally incombination with one or more other pharmacologically active agentsor one or more excipients.21 claims
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公开(公告)号:SK139097A3
公开(公告)日:1998-05-06
申请号:SK139097
申请日:1996-04-10
Applicant: GLAXO WELLCOME INC
Inventor: ASHURST IAN C , HERMAN CRAIG S , LI-BOVET LI , RIEBE MICHAEL T
IPC: A61K9/12 , A61K31/56 , A61K31/569 , A61M15/00 , A61M15/08 , A61M16/00 , A61P11/00 , B05D5/00 , B05D5/08 , B65D83/14
Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.
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公开(公告)号:SK138897A3
公开(公告)日:1998-05-06
申请号:SK138897
申请日:1996-04-10
Applicant: GLAXO WELLCOME INC
Inventor: ASHURST IAN C , HERMAN CRAIG S , LI-BOVET LI , RIEBE MICHAEL T
IPC: A61K9/00 , A61K9/12 , A61K9/72 , A61K31/135 , A61K31/137 , A61K31/57 , A61K31/573 , A61M15/00 , A61P11/08 , B05D5/08 , B05D7/22 , B05D7/24 , B65D83/14
Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising albuterol or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents and one or more excipients.
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