公开(公告)号：CA2200986C

公开(公告)日：2007-03-06

申请号：CA2200986

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： JOHNSON KEITH ARTHUR ,  LI-BOVET LI

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K31/137 ,  A61K31/56 ,  A61K31/66 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluoro-carbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：OA10603A

公开(公告)日：2002-08-30

申请号：OA60982

申请日：1997-03-21

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：OA10625A

公开(公告)日：2001-04-24

申请号：OA70103

申请日：1997-10-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：GR3032245T3

公开(公告)日：2000-04-27

申请号：GR990403333

申请日：1999-12-22

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：CZ286356B6

公开(公告)日：2000-03-15

申请号：CZ93697

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: In the present invention there is disclosed a pharmaceutical in the form of aerosol containing an active substance in particulate form being represented by fluorinated hydrocarbon or chlorinated and fluorinated hydrocarbon, further containing hydrogen atoms as a driving means and wetting agents of the general formulas Ia, and Ib in which the individual symbols have specific meanings. The invented pharmaceutical preparation is intended for inhaling into lungs or into nasal cavity.

公开(公告)号：DE69513671D1

公开(公告)日：2000-01-05

申请号：DE69513671

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：AT187063T

公开(公告)日：1999-12-15

申请号：AT95932166

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：BG102023A

公开(公告)日：1998-07-31

申请号：BG10202397

申请日：1997-11-05

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internalsurfaces coated with one or mom fluorocarbon polymers, optionallyin combination with one or more non-fluorocarbon polymers, fordispensing an inhalation drug formulation comprisingbeclomethasone dipropionate or a physiologically acceptablesolvate thereof, and a fluorocarbon propellant, optionally incombination with one or more other pharmacologically active agentsor one or more excipients.21 claims

公开(公告)号：SK139097A3

公开(公告)日：1998-05-06

申请号：SK139097

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：SK138897A3

公开(公告)日：1998-05-06

申请号：SK138897

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising albuterol or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents and one or more excipients.