公开(公告)号：EP2990850A4

公开(公告)日：2017-01-04

申请号：EP14788270

申请日：2014-04-21

Applicant: HAMAMATSU PHOTONICS KK

Inventor： IWASE FUMIO ,  OKUGAWA MASATOSHI

IPC: G02B21/36 ,  G02B7/28 ,  G02B7/36 ,  G02B21/24 ,  H04N5/232

CPC classification number: G02B21/365 ,  G02B7/36 ,  G02B21/02 ,  G02B21/244 ,  G02B21/26 ,  G02B21/361 ,  G02B21/367 ,  H04N5/23212

Abstract: An image acquisition device 1 uses as as an image pickup element 6 a two-dimensional image pickup element which is adapted to perform rolling readout while having a plurality of pixel columns 31. By utilizing a delay in image data readout timings among the pixel columns 31 in rolling readout, movement of a predetermined part Sa of a sample S within a field V of an objective lens 25 is synchronized with the rolling readout such that each pixel column 31 of the image pickup element 6 is exposed to an optical image of the predetermined part Sa in the sample S, while changing a focal position of the objective lens 25. As a consequence, image data from each pixel column 31 includes contrast information obtained when the focal position of the objective lens 25 is changed in the same part of the sample S, whereby focus information can be calculated rapidly and accurately according to the contrast information.

Abstract translation: 图像采集装置1使用作为作为摄像元件6的二维图像拾取元件的所有这是angepasst执行同时具有像素列31的多个由利用的像素列31中的图像数据读出定时的延迟滚动读出 在物镜25的场V内滚动读出，移动的试样S的预定部分Sa的与滚动读出搜索做了摄像元件6的各像素列31处于预定的光学图像暴露于同步 部Sa在样本S，而改变物镜25的焦点位置作为结果，从每个像素列31的图像数据包括获得当物镜25的焦点位置中的相同部分被改变对比度信息 样品S，由此焦点信息可以计算快速且精确地设定雅丁到的对比度信息。

公开(公告)号：EP2990849A4

公开(公告)日：2017-01-04

申请号：EP14787817

申请日：2014-04-21

Applicant: HAMAMATSU PHOTONICS KK

Inventor： IWASE FUMIO ,  OKUGAWA MASATOSHI

IPC: G02B21/36 ,  G02B7/28 ,  G02B7/36 ,  G02B21/24 ,  G02B21/26 ,  H04N5/232

CPC classification number: H04N5/23212 ,  G02B7/36 ,  G02B21/006 ,  G02B21/244 ,  G02B21/365 ,  G02B21/367

Abstract: An image acquisition device 1 reciprocates a focal position of an objective lens 25 with respect to a sample S in the optical axis direction of the objective lens 25, while moving a field position V of the objective lens 25 with respect to the sample S. This makes it possible to acquire contrast information of image data at the field position V of the objective lens 25 sequentially as the field position V moves with respect to the sample S. The image acquisition device 1 acquires the image data by the rolling readout of the image pickup element 6 according to the reciprocation of the focal position of the objective lens 25. This stabilizes the number of pieces of focus information calculated for each scan of the focal position of the objective lens 25. Therefore, the focus map can be produced rapidly and accurately.

公开(公告)号：EP2990851A4

公开(公告)日：2017-01-04

申请号：EP14788715

申请日：2014-03-07

Applicant: HAMAMATSU PHOTONICS KK

Inventor： OISHI HIDESHI ,  IWASE FUMIO ,  OKUGAWA MASATOSHI

IPC: G02B21/36 ,  G02B7/28 ,  G02B7/34 ,  G02B7/36 ,  G02B7/38 ,  G02B21/24 ,  G02B21/26 ,  G03B3/00 ,  H04N5/232 ,  H04N5/235 ,  H04N5/247 ,  H04N5/262

CPC classification number: H04N5/23212 ,  G02B7/346 ,  G02B7/36 ,  G02B7/365 ,  G02B21/18 ,  G02B21/244 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  H04N5/2351 ,  H04N5/2353 ,  H04N5/247 ,  H04N5/2628

Abstract: In an image acquisition device M, an optical path difference generating member 21 can form an optical path length difference of a second optical image without splitting light in a second optical path L2. This can suppress the quantity of light required for the second optical path L2 to obtain information of the focal position, whereby a quantity of light can be secured for a first imaging device 18 to capture an image. The image acquisition device M synchronizes the movement of a predetermined part of a sample S within a field V of an objective lens 15 with rolling readout such that each pixel column 20b of a second imaging device 20 is exposed to an optical image of the predetermined part in the sample S. Thus obtained image data includes contrast information equivalent to that obtained when the focal position of the objective lens 15 is changed in the same part of the sample S, whereby the focus information can be calculated rapidly and accurately according to the contrast information.

Abstract translation: 在图像获取装置M中，光路差产生部件21可以在第二光路L2中不分裂光而形成第二光学图像的光程长度差。 这可以抑制第二光路L2所需的光量以获得焦点位置的信息，从而可以确保第一成像装置18的光量以捕获图像。 图像获取装置M将物镜15的场V内的样本S的预定部分的移动与滚动读出同步，使得第二成像装置20的每个像素列20b暴露于预定部分的光学图像 这样获得的图像数据包括与在样本S的相同部分中改变物镜15的焦点位置时所获得的对比度信息，由此可以根据对比度快速且准确地计算焦点信息 信息。

公开(公告)号：EP3064982A4

公开(公告)日：2017-11-15

申请号：EP14857047

申请日：2014-01-28

Applicant: HAMAMATSU PHOTONICS KK

Inventor： IWASE FUMIO

IPC: G02B21/36 ,  G02B21/06 ,  H04N5/225 ,  H04N5/238 ,  H04N5/341

CPC classification number: G02B21/367 ,  G02B21/06 ,  G02B21/086 ,  G02B21/241 ,  G06T5/002 ,  H04N5/23212 ,  H04N5/2329

公开(公告)号：EP3064981A4

公开(公告)日：2017-04-05

申请号：EP14856848

申请日：2014-01-28

Applicant: HAMAMATSU PHOTONICS KK

Inventor： IWASE FUMIO

IPC: G02B21/36 ,  H04N5/225

CPC classification number: G06K9/00134 ,  G02B21/06 ,  G02B21/086 ,  G02B21/26 ,  G02B21/365 ,  G02B21/367 ,  H04N5/23238

Abstract: In this image acquisition device (1), a stage driving unit (11) (driving unit) moves a position of a field of view of an objective lens (25) relative to a sample at a predetermined velocity, and a two-dimensional imaging element (6) sequentially captures an optical image of the sample (S) at a predetermined frame rate. Therefore, time required for acquiring partial images over the entire sample (S) is shortened. Further, in this image acquisition device (1), the moving velocity of the position of the field of view is a velocity set based on a frame rate of the imaging element (6). Therefore, the movement of the position of the field of view and the imaging of the imaging element (6) are synchronized with each other, and it is possible to capture only necessary partial images. Therefore, in this image acquisition device (1), the acquisition of the partial images and the combination of all the images can be executed at high speed.

公开(公告)号：EP1550857A4

公开(公告)日：2006-12-20

申请号：EP03748660

申请日：2003-10-01

Applicant: HAMAMATSU PHOTONICS KK

Inventor： MARUNO TADASHI ,  IWASE FUMIO ,  SATO TAIGA

IPC: G01J1/58 ,  G01J3/28 ,  G01J3/44 ,  G01N21/64 ,  H04N5/321 ,  H04N5/335 ,  H04N5/353 ,  H04N5/3728 ,  H04N5/376 ,  G01J1/42

CPC classification number: G01J3/4406 ,  G01J3/2889 ,  G01N21/64 ,  H04N5/321

Abstract: A fluorescence measuring device having a CCD camera applied thereto that is capable of measuring a fluorescent component emitted from a measurement subject in response to an excitation pulse component with which the measuring subject is periodically irradiated. The fluorescence measuring device is at least provided with a CCD, and a control section. The CCD comprises a photoelectric conversion element that photoelectrically converts fluorescent component emitted from a measurement subject, and a charge-storage element that stores and transfers the charges photoelectrically converted by the photoelectric conversion element. The control section outputs an electron shutter signal for sweeping away the charges photoelectrically converted by the photoelectric conversion element, a readout signal for reading out the photoelectrically converted charges into the charge-storage element, and a transfer signal for successively transferring the charges that have been read out. Particularly, the control section outputs an electron shutter signal in response to the generation of an excitation pulse component and outputs a readout signal in response to the outputting of the electron shutter signal, and outputs transfer signals every predetermined number of times of outputting of the readout signal.

公开(公告)号：JP2006227315A

公开(公告)日：2006-08-31

申请号：JP2005041183

申请日：2005-02-17

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： IWASE FUMIO ,  MARUNO TADASHI

IPC: G02B21/00 ,  G02B21/36 ,  H04N5/225 ,  H04N5/232 ,  H04N5/335 ,  H04N5/341 ,  H04N5/369 ,  H04N5/3725 ,  H04N5/3728

Abstract: PROBLEM TO BE SOLVED: To provide an imaging apparatus capable of efficiently performing an imaging operation synchronously with an external trigger signal, and to provide an imaging system, a confocal microscope, and an imaging method.
SOLUTION: The imaging apparatus 20 of the confocal microscope 1 includes: a CCD element 21 having an imaging section and a reading section; and an imaging control section 22 that controls an image exposing operation of the imaging section of the CCD element 21 and the charge reading operation of the reading section. The imaging control section 22 controls an exposing period of the imaging section so as to synchronize with an external trigger signal. The imaging control section 22 also controls the operation of the CCD element 21 so that the reading of image data captured by the imaging section during a first exposing period is initiated by the reading section at the same time as a second exposing period of the imaging section after the first exposing period thereof.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 解决的问题：提供能够与外部触发信号同步地有效地进行成像操作的成像装置，并提供成像系统，共聚焦显微镜和成像方法。 共焦显微镜1的成像装置20包括：具有成像部和读取部的CCD元件21; 以及成像控制部分22，其控制CCD元件21的成像部分的图像曝光操作和读取部分的电荷读取操作。 成像控制部分22控制成像部分的曝光时间段，以便与外部触发信号同步。 成像控制部分22还控制CCD元件21的操作，使得在第一曝光时段期间由成像部分拍摄的图像数据的读取在读取部分与成像部分的第二曝光时段同时启动 在其第一曝光期之后。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2001169192A

公开(公告)日：2001-06-22

申请号：JP35483799

申请日：1999-12-14

Applicant: HAMAMATSU PHOTONICS KK

Inventor： MARUNO TADASHI ,  IWASE FUMIO

IPC: H01J29/45 ,  H01J31/26 ,  H01L27/14 ,  H04N5/335 ,  H04N5/372 ,  H04N5/374 ,  H04N5/376 ,  H04N5/378

Abstract: PROBLEM TO BE SOLVED: To provide an image pickup device capable of obtaining satisfactory quality image. SOLUTION: An EB-CCD is known as an image pickup device for transferring electrons generated in a semiconductor image pickup area 1i by electronic multiplication, due to the collision of electrons and outputting a pixel signal from an amplifier 1to. Since this image pickup device controls so that both the acceleration voltage and the signal reading speed of the electrons are optimal, the satisfactory quantity image is obtained.

公开(公告)号：JP2013098420A

公开(公告)日：2013-05-20

申请号：JP2011241343

申请日：2011-11-02

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： SUYAMA MOTOHIRO ,  UJIMA AKIOMI ,  MAEDA KENTARO ,  SUZUKI HISANORI ,  MURAMATSU MASAHARU ,  IWASE FUMIO

IPC: H01L27/148 ,  H04N5/3728

CPC classification number: H01L27/14843 ,  H04N3/1525 ,  H04N3/1537 ,  H04N5/3722

Abstract: PROBLEM TO BE SOLVED: To provide a solid state imaging device capable of reducing a time required for imaging when imaging by TDI operation.SOLUTION: A solid state imaging device 1A includes: a CCD solid state imaging element 10 having an imaging plane 12 composed of M×N pixels (M, N are integers of 2 or greater) two-dimensionally arrayed with M rows and N columns, N signal readout circuits 20 arranged column-by-column on one side of the imaging plane in the column direction relative to the imaging plane 12, and N signal readout circuits 30 arranged column-by-column on the other side of the imaging plane in the column direction relative to the imaging plane; a semiconductor element 50 for digital converting electric signals output column-by-column from the signal readout circuit 20 into digital signals, to sequentially output as serial signals; and a semiconductor element 60 for digital converting electric signals output column-by-column from the signal readout circuit 30 into digital signals, to sequentially output as serial signals.

Abstract translation: 要解决的问题：提供一种固态成像装置，其能够在通过TDI操作成像时减少成像所需的时间。 固态成像装置1A包括：CCD固态成像元件10，具有由M×N个像素（M，N为2以上的整数）构成的成像面12，二维地排列成M行， N列，相对于成像面12在列方向上在成像面的一侧上逐列排列的N个信号读出电路20，以及N个信号读取电路30， 成像平面相对于成像平面在列方向上; 用于将从信号读出电路20逐列输出的电信号数字转换为数字信号的半导体元件50顺序地输出为串行信号; 以及用于将从信号读出电路30逐列输出的电信号数字转换为数字信号的半导体元件60，作为串行信号依次输出。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2006145634A

公开(公告)日：2006-06-08

申请号：JP2004332385

申请日：2004-11-16

Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

Inventor： MARUNO TADASHI ,  IWASE FUMIO

IPC: G02B21/00

Abstract: PROBLEM TO BE SOLVED: To provide a confocal image measuring system for preferably attaining synchronization of a Nieuwpoort disk and an imaging device, and to provide a confocal microscope and a confocal image measuring method.
SOLUTION: The confocal measuring system applies a measuring system 2 comprising a scanning trigger supply part 15 corresponding to a scanning cycle of a sample S by the Nieuwpoort disk 10 by detecting rotation of the Nieuwpoort disk 10 to the confocal microscope 1 acquiring a confocal image of the sample S generated by the Nieuwpoort disk 10 and an image acquiring device 20 for acquiring the confocal image of the sample S. In addition, the confocal measuring system comprises composing the image acquiring device 20 by using an FT type CCD element 21, setting an imaging cycle on the basis of the scanning cycle found by a scanning trigger signal and a vertical forward time from an imaging part in the CCD element 21 to a storing part and controlling acquisition of the confocal image using the CCD element 21 by the imaging cycle.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种用于优选实现Nieuwpoort盘和成像装置的同步的共焦图像测量系统，并提供共聚焦显微镜和共聚焦图像测量方法。 解决方案：共焦测量系统通过检测Nieuwpoort磁盘10到共聚焦显微镜1的旋转来应用由Nieuwpoort磁盘10对应于样品S的扫描周期的扫描触发器供应部分15的测量系统2， 由Nieuwpoort磁盘10产生的样本S的共焦图像和用于获取样本S的共焦图像的图像获取装置20.另外，共焦测量系统包括通过使用FT型CCD元件21来组成图像获取装置20 基于由扫描触发信号和从CCD元件21中的成像部分到存储部分的垂直前进时间发现的扫描周期来设置成像周期，并且使用CCD元件21控制获取共焦图像 成像周期。 版权所有（C）2006，JPO＆NCIPI