公开(公告)号：JPH08301791A

公开(公告)日：1996-11-19

申请号：JP11477095

申请日：1995-05-12

Applicant: AGENCY IND SCIENCE TECHN ,  HISAMITSU PHARMACEUTICAL CO ,  HITACHI CHEMICAL CO LTD

Inventor： TAHIRA KAZUMASA ,  NISHIKAWA SATOSHI ,  WADA AKIRA ,  GOTO TAKESHI ,  SATO HIDEJI ,  YAMADA AKIRA ,  SHIMAYAMA TAKASHI

IPC: A61K9/00 ,  A61K31/7088 ,  A61K47/42 ,  A61K48/00

Abstract: PURPOSE: To provide a histone carrier for functional oligonucleotides stable in living bodies. CONSTITUTION: The production process for histone carrier for functional oligonucleotide in which histone units are mixed in the order of H2a→H2b→H 3→H4→H1 to reconstruct the parent histone. A complex of a functional oligonucleotide and the histone carrier which is prepared by effecting the reconstruction of the histone carrier in the presence of a functional oligonuleotide in the reconstruction of the carrier by mixing the subunits of histone.

公开(公告)号：JPH04334327A

公开(公告)日：1992-11-20

申请号：JP13542291

申请日：1991-05-11

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： SATO HIDEJI ,  YAMAGUCHI HISASHI ,  NOZAWA ITSUKI ,  AKIYAMA KATSUHIKO

IPC: A61K9/06 ,  A61K9/70 ,  A61K47/14

Abstract: PURPOSE:To provide the title composition markedly improved in the percutaneous absorption and penetration for the medicine formulated therein. CONSTITUTION:To objective composition can be obtained by formulating (A) an absorption-promotive composition comprising, as the essential components, an acetate of formula CH3C00R (R is 1-10C alkyl group), lower alcohol and polar solvent with (B) a medicine. The present composition, which has been significantly enhanced and promoted in percutaneously absorptive activity, is useful as a percutaneously absorbable pharmaceutical preparation designed to make percutaneous administration.