公开(公告)号：JPH04334326A

公开(公告)日：1992-11-20

申请号：JP13542391

申请日：1991-05-11

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： SATO HIDEJI ,  YAMAGUCHI HISASHI ,  NOZAWA ITSUKI ,  KUSUNOKI TAKASANE ,  NAKAJIMA MIKIO

IPC: A61K9/06 ,  A61K9/70 ,  A61K45/00 ,  A61K47/22 ,  A61P25/04

Abstract: PURPOSE:To obtain the title composition improved in percutaneous absorbability by formulating a specified base with a narcotic or narcotically antagonistic analgesic. CONSTITUTION:The objective composition can be obtained by formulating (A) a base comprised of a lower alcohol, polar solvent and azacycloalkane derivative with (B) as medicinal ingredient, a narcotic or narcotically antagonistic analgesic. The present composition, which has been enhanced in the percutaneous penetrability/permeability for the medicinal ingredient, has significant absorption-promotive activity.

公开(公告)号：JPH04334327A

公开(公告)日：1992-11-20

申请号：JP13542291

申请日：1991-05-11

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： SATO HIDEJI ,  YAMAGUCHI HISASHI ,  NOZAWA ITSUKI ,  AKIYAMA KATSUHIKO

IPC: A61K9/06 ,  A61K9/70 ,  A61K47/14

Abstract: PURPOSE:To provide the title composition markedly improved in the percutaneous absorption and penetration for the medicine formulated therein. CONSTITUTION:To objective composition can be obtained by formulating (A) an absorption-promotive composition comprising, as the essential components, an acetate of formula CH3C00R (R is 1-10C alkyl group), lower alcohol and polar solvent with (B) a medicine. The present composition, which has been significantly enhanced and promoted in percutaneously absorptive activity, is useful as a percutaneously absorbable pharmaceutical preparation designed to make percutaneous administration.

公开(公告)号：JPH06199659A

公开(公告)日：1994-07-19

申请号：JP28995292

申请日：1992-10-28

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： SATO HIDEJI ,  YAMAGUCHI HISASHI ,  NOZAWA ITSUKI ,  MAEDA HIROYUKI

IPC: A61K9/70

Abstract: PURPOSE:To obtain an apparatus for percutaneous treatment capable of accurately and surely feeding a prescribed amount of a medicine to a lesion part because of being free from loss of the medicine accompanied by removal of release liner in using. CONSTITUTION:A porous material constituting a medicine release material layer 3 for releasing a medicine from a medicine storage tank 2 to skin is subjected to coating treatment or impregnation treatment with a nonionic surfactant.