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    PRODUCTION OF RECOMBINANT ADENO-ACCOMPANYING VIRUS VECTOR
    2.
    发明专利
    PRODUCTION OF RECOMBINANT ADENO-ACCOMPANYING VIRUS VECTOR 失效

    公开(公告)号：JPH1033175A

    公开(公告)日：1998-02-10

    申请号：JP21310196

    申请日：1996-07-24

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： IIJIMA OSAMU ,  SATO HIDEJI ,  SAITO IZUMI ,  SHIMADA TAKASHI

    IPC: C12N15/09 ,  C12N5/10

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject vector useful for a gene therapy and in the fields of medicine and biochemistry, etc., by inserting a specific stuffer sequence into an adeno-accompanying virus(AAV) genome sequenpe. SOLUTION: A stuffer sequence held between two recombinase recognition sequences is inserted between a promotor p5 of a helper plasmid derived from a genome of a wild type AAV and a translational initiation codon of rep78/68 gene. The stuffer sequence contains at least one detectable gene marker and a poly-A signal in the same direction as the promotor p5 and the rep78/68 gene. The helper plasmid is subjected to a gene insertion into a 293 cell to obtain a packaging cell for producing a recombinant AAV vector, and a recombinant AAV vector plasmid such as a pNAV and a Cre-expressing plasmid are subjected to a transfection, and an adenovirus is simultaneously infected thereto and then cultured to obtain the objective high-titer recombinant AAV vector.

    APPARATUS FOR PERCUTANEOUS TREATMENT
    6.
    发明专利
    APPARATUS FOR PERCUTANEOUS TREATMENT 失效

    公开(公告)号：JPH06199659A

    公开(公告)日：1994-07-19

    申请号：JP28995292

    申请日：1992-10-28

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： SATO HIDEJI ,  YAMAGUCHI HISASHI ,  NOZAWA ITSUKI ,  MAEDA HIROYUKI

    IPC: A61K9/70

    Abstract: PURPOSE:To obtain an apparatus for percutaneous treatment capable of accurately and surely feeding a prescribed amount of a medicine to a lesion part because of being free from loss of the medicine accompanied by removal of release liner in using. CONSTITUTION:A porous material constituting a medicine release material layer 3 for releasing a medicine from a medicine storage tank 2 to skin is subjected to coating treatment or impregnation treatment with a nonionic surfactant.

    PATCH HAVING LAMINATED SUPPORT
    8.
    发明专利
    PATCH HAVING LAMINATED SUPPORT 审中-公开

    公开(公告)号：JP2003137773A

    公开(公告)日：2003-05-14

    申请号：JP2001335334

    申请日：2001-10-31

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： TATEISHI TETSUO ,  HIGO SHIGETO ,  SATO HIDEJI

    IPC: A61F13/00 ,  A61F13/02 ,  A61K9/70 ,  B32B7/12 ,  B32B27/12 ,  B32B27/36

    Abstract: PROBLEM TO BE SOLVED: To provide a readily attachable patch excellent in softness, not causing curling phenomenon, excellent in adhesiveness and feelings upon use and having sufficient skin-through property of a medicine, because absorption of the medicine to the support does not occur. SOLUTION: This patch has a laminated support obtained by laminating a knitted fabric on one surface of a polyester film and an adhesive layer containing a medicine and laminated to the other surface of the polyester film. In the patch, the knitted fabric has 0.1 kg/5 cm to 20 kg/5 cm 30% modulus in the vertical direction and =2 ratio of the 30% modulus in the vertical direction to the 30% modulus in the horizontal direction.

    EFFICIENT PRODUCTION OF USEFUL SUBSTANCE BY APOPTOSIS INHIBITION AND CELL
    9.
    发明专利
    EFFICIENT PRODUCTION OF USEFUL SUBSTANCE BY APOPTOSIS INHIBITION AND CELL 失效

    公开(公告)号：JPH09163983A

    公开(公告)日：1997-06-24

    申请号：JP23112496

    申请日：1996-08-30

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： SUZUKI EIJI ,  YUDA KAZUHIRO ,  AKIYAMA KATSUHIKO ,  GOTO TAKESHI ,  SATO HIDEJI

    IPC: C12N15/09 ,  A61K39/00 ,  A61K39/395 ,  C12N5/00 ,  C12N5/10 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

    Abstract: PROBLEM TO BE SOLVED: To extremely improve productivity of a useful substance such as an antibody, a vector for gene therapy, cytokinin, an antigen for vaccine, etc., by transducing an apoptosis inhibitory gene to an animal cell capable of producing a useful substance. SOLUTION: An apoptosis inhibitory gene such as bcl-2, BAG-1, Bcl-XL, Ad.Elb or CrmA is transduced to bcl-2 transduced COS-1 cell (FERM P-15,808) as an animal cell capable of producing a useful substance by an electroporation method. A selective pressure is applied to the system to select a gene-transduced cell, which is cultured in a medium to mass produce a useful substance such as various antibodies produced by a hybridoma, a virus vector for treating a gene, various recombinant protein such as a cytokine, e.g. interferon, an antigen substance for a vaccine, etc., in improved productivity.

    NON-CROSS-LINKED ANION EXCHANGE RESIN
    10.
    发明专利
    NON-CROSS-LINKED ANION EXCHANGE RESIN 失效

    公开(公告)号：JPH08208750A

    公开(公告)日：1996-08-13

    申请号：JP31706695

    申请日：1995-11-13

    Applicant: HISAMITSU PHARMACEUTICAL CO

    Inventor： OKAYAMA MINENOBU ,  SATO HIDEJI

    IPC: A61K31/785 ,  A61P3/06 ,  B01J41/14 ,  C08F20/34

    Abstract: PURPOSE: To obtain a non-cross-linked anion exchange resin used as a cholesterol lowering agent reduced in side effects such as the feeling of abdominal inflation and obstipation, freed from conventional drawbacks that it absorbs fat-soluble vitamins and that the difficulty in taking it is considerably large, freed from the inconvenience that it must be suspended when it is taken and being easily taken in the form of tablets, granules, capsules, or the like. CONSTITUTION: An anion exchange resin comprising repeating units of the formula [wherein R1 is benzyl or 1-20 C alkyl; R2 and R3 are the same or different from each other and each 1-4 C lower alkyl; R4 is hydrogen or lower alkyl group. X is a physiologically acceptable counter ion; n is 1-3; and p is the average degree of polymerization and is 10-10000].

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