公开(公告)号：DK166586C

公开(公告)日：1993-11-08

申请号：DK11984

申请日：1984-01-11

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  URBACH HANSJOERG ,  TEETZ VOLKER ,  BECKER REINHARD

IPC: A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/96 ,  C07D317/28 ,  C07D317/30 ,  C07D317/32 ,  C07D317/72 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K14/81

Abstract: The invention relates to new spirocyclic aminoacid derivatives of the formula I (I) in which m denotes 1 or 2, n denotes 0 or 1, R denotes hydrogen, alkyl or aralkyl, R1 denotes hydrogen or alkyl which can be optionally substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted as defined above in the aryl radical, an S- or O- and/or N-heterocyclic radical or a side chain of an alpha -aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, processes for their preparation, agents containing them and their use and new spirocyclic aminoacids as intermediates and a process for their preparation.

公开(公告)号：LV5255A3

公开(公告)日：1993-10-10

申请号：LV930305

申请日：1993-05-07

Applicant: HOECHST AG

Inventor： TEETZ VOLKER ,  GEIGER ROLF ,  URBACH HANSJORG ,  BECKER REINHARD ,  SCHOLKENS BERNWARD

IPC: C07D451/02

公开(公告)号：ZA9236B

公开(公告)日：1993-10-04

申请号：ZA9236

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER ,  SCHOELKENS BERNWARD ,  LINZ WOLFGANG ,  ENGLERT HEINRICH ,  GERHARDS HERMANN ,  BECKER REINHARD ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K20060101 ,  A61K31/40 ,  A61K31/425 ,  C07D20060101 ,  C07D207/30 ,  C07D257/04 ,  C09F20060101 ,  C07D ,  A61K ,  C09F

公开(公告)号：ZA9200036B

公开(公告)日：1993-10-04

申请号：ZA9200036

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER ,  SCHOELKENS BERNWARD ,  LINZ WOLFGANG ,  ENGLERT HEINRICH ,  GERHARDS HERMANN ,  BECKER REINHARD ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K20060101 ,  A61K31/40 ,  A61K31/425 ,  C07D20060101 ,  C07D207/30 ,  C07D257/04 ,  C09F20060101 ,  C07D ,  A61K ,  C09F

公开(公告)号：AU3401193A

公开(公告)日：1993-09-09

申请号：AU3401193

申请日：1993-03-05

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  WAGNER ADALBERT ,  GERHARDS HERMANN ,  BECKER REINHARD ,  SCHOLKENS BERNWARD

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90

Abstract: Compounds of the formula (I) in which R is, for example, ethyl, R is, for example, methyl, n is, for example, zero, R is, for example, COOH and R is, for example, SO2NHCONHCH3 are highly active antagonists of angiotensin II receptors.

公开(公告)号：NO172940B

公开(公告)日：1993-06-21

申请号：NO862043

申请日：1986-05-22

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  BECKER REINHARD

IPC: A61K38/00 ,  A61K38/55 ,  C07D521/00 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07K1/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/068 ,  C07K14/81

Abstract: The derivatives have the formula I in which n is 0, 1 or 2, R is hydrogen, alkyl or aralkyl, R is hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, optionally substituted aryl or partially hydrogenated aryl, aryl-(C1-C4)-alkyl or aroyl-C1-alkyl, both of which can be substituted, a mono- or bicyclic heterocyclic radical or a side chain of a naturally occurring amino acid, R is hydrogen, alkyl, alkenyl or aralkyl, X is alkyl, alkenyl, cycloalkyl, aryl which can be substituted, or 3-indolyl.

公开(公告)号：NO930817D0

公开(公告)日：1993-03-05

申请号：NO930817

申请日：1993-03-05

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  WAGNER ADALBERT ,  GERHARDS HERMANN ,  BECKER REINHARD ,  SCHOELKENS BERNWARD

IPC: A61K31/4164 ,  A61K31/415 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90 ,  C07D

Abstract: Compounds of the formula (I) in which R is, for example, ethyl, R is, for example, methyl, n is, for example, zero, R is, for example, COOH and R is, for example, SO2NHCONHCH3 are highly active antagonists of angiotensin II receptors.

公开(公告)号：CA1313371C

公开(公告)日：1993-02-02

申请号：CA558818

申请日：1988-02-12

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG ,  HENNING RAINER ,  SCHOELKENS BERNWARD ,  BECKER REINHARD

IPC: C07D223/32 ,  A61K31/395 ,  A61K31/445 ,  A61K31/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00 ,  C07D225/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07K5/02 ,  C07K5/06

Abstract: HOE 87/F 048 Fused azepinone and azocinone derivatives, processes for their preparation, agents containing them and their use, and intermediates in their preparation The invention relates to compounds of the formula I (I) in which m denotes 1 or 2 and n denotes 0, 1 or 2; R1 and R2 denote identical or different radicals from the series comprising hydrogen, optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, partly hydrogenated aryl and optionally substituted aralkyl; R3 and R4 denote identical or different radicals from the series comprising hydrogen, alkyl, alkenyl and optionally substituted aralkyl; Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxo, and X denotes optionally substituted alkyl, alkenyl, cycloalkyl, optionally substituted 4-piperidinyl, optionally substituted aryl or indolyl, processes for their preparation, medicaments containing these compounds and their use in the treatment of hypertension or heart diseases, and to intermediates in their preparation.

公开(公告)号：DK164789C

公开(公告)日：1993-01-04

申请号：DK138283

申请日：1983-03-25

Applicant: HOECHST AG

Inventor： TEETZ VOLKER ,  URBACH HANSJOERG ,  BECKER REINHARD

IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  C07D209/54 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

Abstract: The invention relates to compounds of the formula I (I) in which n denotes 1, 2, 3 or 4, R is alkyl, alkenyl cycloalkyl, aryl, optionally mono-, di- oder trisubstituted by alkyl, alkoxy, hydroxy, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol-3-yl, R1 denotes an optionally protected radical of a naturally occurring amino acid HOOC-CH(NH2)-R1, R2 denotes hydrogen, alkyl or optionally nitro-substituted aralkyl, R3 denotes hydrogen, alkyl or cycloalkyl or optionally nitro-substituted aralkyl and X denotes 2 hydrogen atoms or 1 oxygen atom, their physiologically tolerated salts with acids and, if R2 and/or R3 denote hydrogen, with bases, a process for their preparation, agents containing these derivatives and their use as medicaments.

公开(公告)号：DK114492D0

公开(公告)日：1992-09-17

申请号：DK114492

申请日：1992-09-17

Applicant: HOECHST AG

Inventor： TEETZ VOLKER ,  GEIGER ROLF ,  URBACH HANSJOERG ,  BECKER REINHARD ,  SCHOELKENS BERNWARD

IPC: C07C227/08 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  C07C227/10 ,  C07C227/16 ,  C07C229/28 ,  C07C229/36 ,  C07C237/06 ,  C07D209/52 ,  C07D451/04 ,  C07K5/02 ,  C07K5/06

Abstract: Compounds of the formula I (I) in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring alpha -aminoacid, which may be protected, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these compounds and their use.