公开(公告)号：JPH07304728A

公开(公告)日：1995-11-21

申请号：JP2411994

申请日：1994-02-22

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42

公开(公告)号：WO9746226A3

公开(公告)日：1998-03-05

申请号：PCT/EP9702548

申请日：1997-05-20

Applicant: HOECHST AG ,  LANG HANS JOCHEN ,  JANSEN HANS WILLI ,  SCHWARK JAN ROBERT ,  KLEEMANN HEINZ WERNER ,  JUNG OLIVER ,  SCHAEFER HANS LUDWIG ,  LINZ WOLFGANG ,  KRAMER WERNER ,  SCHOELKENS BERNWARD ,  FALK EUGEN

Inventor： LANG HANS JOCHEN ,  JANSEN HANS-WILLI ,  SCHWARK JAN-ROBERT ,  KLEEMANN HEINZ-WERNER ,  JUNG OLIVER ,  SCHAEFER HANS-LUDWIG ,  LINZ WOLFGANG ,  KRAMER WERNER ,  SCHOELKENS BERNWARD ,  FALK EUGEN

IPC: A61K31/155 ,  A61K31/00 ,  A61K31/166 ,  A61K31/22 ,  A61K31/255 ,  A61K31/365 ,  A61K31/41 ,  A61K31/455 ,  A61K45/00 ,  A61K45/06 ,  A61P3/00 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00

CPC classification number: A61K31/166 ,  A61K31/00 ,  A61K31/155 ,  A61K31/22 ,  A61K31/365 ,  A61K31/165 ,  A61K2300/00

Abstract: The active substances identified as inhibitors of the cellular Na+/H+ exchanger (NHE) are used to prepare a medicament for normalizing serum lipids. They are used in the preparation of a medicament which reduces lipid levels in the blood and can be administered for treating diseases caused by lipid levels which are too high, and for alleviating the endothelial dysfunctional syndrome and for treating diseases caused thereby.

Abstract translation: 被鉴定为细胞Na + / H +交换剂（NHE）的抑制剂的活性物质用于制备用于使血清脂质正常化的药物。 它们用于制备降低血液中脂质水平并且可以用于治疗由过高的脂质水平引起的疾病以及用于缓解内皮功能障碍综合征和用于治疗由此引起的疾病的药物的药物。

公开(公告)号：JPH10139775A

公开(公告)日：1998-05-26

申请号：JP31186597

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12

Abstract: PROBLEM TO BE SOLVED: To produce the subject new compound, having amide group at the 3-position of the chroman system and useful for treatment of especially arrhythmia, prevention of sudden cardiac death and treatment and prevention, etc., of weakened cardiac forces in order to treat disorders in the cardiovascular system. SOLUTION: This is represented by formula I [R(3) is H or a 1-4C alkyl; R(1) is R(3), a 1-4C alkoxy, a halogen, etc.; R(2a) to R(2c) are each H or a 1-2C alkyl; Z is O or S; A is phenyl (substituted with 1 to 3 halogens, 1-2C alkyl groups or alkoxy groups), etc.] or its salt, e.g. 3-(5-chloro-2- methoxybenzamido)-6-(methylaminocarbonylaminosulfonyl)-7methoxychroman. The compound represented by formula I in which Z is O is obtained by reacting a compound represented by formula II with a compound represented by formula III in the presence of a base.

公开(公告)号：PL189950B1

公开(公告)日：2005-10-31

申请号：PL33041297

申请日：1997-05-20

Applicant: HOECHST AG

Inventor： LANG HANS JOHEN ,  JANSEN HANS-WILLI ,  SCHWARK JAN-ROBERT ,  KLEEMANN HEINZ-WERNER ,  JUNG OLIVER ,  SCHAEFER HANS-LUDWIG ,  LINZ WOLFGANG ,  KRAMER WERNER ,  SCHOELKENS BERNWARD ,  FALK EUGEN

IPC: A61K31/155 ,  A61K31/00 ,  A61K31/166 ,  A61K31/22 ,  A61K31/255 ,  A61K31/365 ,  A61K31/41 ,  A61K31/455 ,  A61K45/00 ,  A61K45/06 ,  A61P3/00 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00

Abstract: The active substances identified as inhibitors of the cellular Na /H exchanger (NHE) are used to prepare a medicament for normalizing serum lipids. They are used in the preparation of a medicament which reduces lipid levels in the blood and can be administered for treating diseases caused by lipid levels which are too high, and for alleviating the endothelial dysfunctional syndrome and for treating diseases caused thereby.

公开(公告)号：NO317152B1

公开(公告)日：2004-08-30

申请号：NO975214

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： KLAUS ERIK ,  LINZ WOLFGANG ,  GOGELEIN HEINZ ,  ENGLERT HEINRICH ,  GERLACH UWE ,  MANIA DIETER

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D311/20

Abstract: 3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.

公开(公告)号：PL186505B1

公开(公告)日：2004-01-30

申请号：PL31739796

申请日：1996-12-09

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CH ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK ,  CRAUSE PETER

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  C07D311/58 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12

Abstract: N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.

公开(公告)号：HRP970603B1

公开(公告)日：2002-08-31

申请号：HRP970603

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D401/12 ,  C07D403/12

Abstract: 3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.

公开(公告)号：PT779288E

公开(公告)日：2000-07-31

申请号：PT96119262

申请日：1996-12-02

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  ENGLERT HEINRICH CHRISTIAN ,  CRAUSSE PETER ,  KLAUS ERIK ,  MANIA DIETER ,  GOGELEIN HEINZ ,  UWE GERLACH DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  C07D311/58 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12

Abstract: N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.

公开(公告)号：AU707371B2

公开(公告)日：1999-07-08

申请号：AU7531296

申请日：1996-12-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOGELEIN HEINZ ,  KLAUS ERIK ,  CRAUSE PETER

IPC: C07D311/58 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12

Abstract: N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.

公开(公告)号：TR199802505T2

公开(公告)日：1999-04-21

申请号：TR9802505

申请日：1997-05-20

Applicant: HOECHST AG

Inventor： LANG JOCHEN HANS ,  JANSEN HANS-WILLI ,  SCHWARK JAN-ROBERT ,  KLEEMANN HEINZ-WERNER ,  JUNG OLIVER ,  FER HANS-LUDWIG SCH ,  LINZ WOLFGANG ,  KRAMER WERNER ,  SCHOELKENS BERNWARD ,  FALK EUGEN

IPC: A61K31/155 ,  A61K31/00 ,  A61K31/166 ,  A61K31/22 ,  A61K31/255 ,  A61K31/365 ,  A61K31/41 ,  A61K31/455 ,  A61K45/00 ,  A61K45/06 ,  A61P3/00 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00

Abstract: The active substances identified as inhibitors of the cellular Na /H exchanger (NHE) are used to prepare a medicament for normalizing serum lipids. They are used in the preparation of a medicament which reduces lipid levels in the blood and can be administered for treating diseases caused by lipid levels which are too high, and for alleviating the endothelial dysfunctional syndrome and for treating diseases caused thereby.