公开(公告)号：AT29889T

公开(公告)日：1987-10-15

申请号：AT83111079

申请日：1983-11-07

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG DR ,  HENNING RAINER DR ,  BECKER REINHARD DR

IPC: C07D209/70 ,  A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/58 ,  C07D221/22 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  A61K37/02

公开(公告)号：DE3518514A1

公开(公告)日：1986-11-27

申请号：DE3518514

申请日：1985-05-23

Applicant: HOECHST AG

Inventor： URBACH HANSJOERG DR ,  HENNING RAINER DR ,  BECKER REINHARD DR

IPC: C07D521/00 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07K1/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/068 ,  C07K14/81 ,  C07D403/00 ,  C07D405/06 ,  C07D409/06 ,  A61K31/40

Abstract: The derivatives have the formula I in which n is 0, 1 or 2, R is hydrogen, alkyl or aralkyl, R is hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, optionally substituted aryl or partially hydrogenated aryl, aryl-(C1-C4)-alkyl or aroyl-C1-alkyl, both of which can be substituted, a mono- or bicyclic heterocyclic radical or a side chain of a naturally occurring amino acid, R is hydrogen, alkyl, alkenyl or aralkyl, X is alkyl, alkenyl, cycloalkyl, aryl which can be substituted, or 3-indolyl.

公开(公告)号：DE3366919D1

公开(公告)日：1986-11-20

申请号：DE3366919

申请日：1983-03-18

Applicant: HOECHST AG

Inventor： URBACH HANSJORG DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  WISSMANN HANS DR ,  BECKER REINHARD DR

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D209/42 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81

Abstract: The invention relates to compounds of the formula I (I) in which n denotes 0 or 1, R denotes hydrogen, alkyl or aralky, R1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, which each can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined in the aforegoing, a monocyclic or bicyclic sulfur or oxygen and/or nitrogen heterocyclic radical, or a side chain of a naturally occurring aminoacid, R2 denotes hydrogen, alkyl, alkenyl or arylalkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which is monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy or 3-indolyl, and their physiologically acceptable salts, processes for their preparation, agents containing these and their use as medicaments and also bicyclic amino acids as their intermediates and processes for their preparation.

公开(公告)号：AT18550T

公开(公告)日：1986-03-15

申请号：AT82110070

申请日：1982-11-02

Applicant: HOECHST AG

Inventor： TEETZ VOLKER DR ,  GEIGER ROLF PROF DR ,  URBACH HANSJOERG DR ,  BECKER REINHARD DR ,  SCHOELKENS BERNWARD DR

IPC: A61K31/40 ,  C07D209/52 ,  C07C101/28 ,  C07C101/34

公开(公告)号：DK0560177T3

公开(公告)日：2003-04-14

申请号：DK93103301

申请日：1993-03-02

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  WAGNER ADALBERT DR ,  SCHOELKENS BERNWARD PROF DR ,  HEITSCH HOLGER DR ,  GERHARDS HERMANN DR

IPC: A61K31/4164 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  C07D233/84 ,  A61K31/415 ,  C07D233/86 ,  C07D233/90

Abstract: Compounds of the formula (I) in which R is, for example, ethyl, R is, for example, methyl, n is, for example, zero, R is, for example, COOH and R is, for example, SO2NHCONHCH3 are highly active antagonists of angiotensin II receptors.

公开(公告)号：CY2109B1

公开(公告)日：2002-04-26

申请号：CY9800023

申请日：1998-09-04

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  URBACH HANSJORG DR

IPC: A61K38/55 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/425 ,  A61K31/455 ,  A61K31/47 ,  A61K31/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00

Abstract: An angiotensin converting enzyme inhibitor (I) can be used in combination with Ca antagonists (III) in the prevention and therapy of proteinuria. Pref. (A) Ramipril and felodipine; (B) Ramipril and 4-(2,3-dichlorophenyl) -2,6-dimethyl-3- (1,2,4-oxadiazol-5-yl) -S-isopropoxy carbonyl-1,4-dihydropyridine (IIb), (c) Trandolapril and felodipine; (D) Trandolapril and (IIb), (E) Trandolapril and Verapamil; (F) Quinapril and felodipine; (G) Quinapril and (IIIb) or the physiologically acceptable salts of these components.

公开(公告)号：DE59109099D1

公开(公告)日：1999-03-25

申请号：DE59109099

申请日：1991-11-21

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  URBACH HANSJOERG DR

IPC: A61K38/55 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/425 ,  A61K31/455 ,  A61K31/47 ,  A61K31/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00

Abstract: An angiotensin converting enzyme inhibitor (I) can be used in combination with Ca antagonists (III) in the prevention and therapy of proteinuria. Pref. (A) Ramipril and felodipine; (B) Ramipril and 4-(2,3-dichlorophenyl) -2,6-dimethyl-3- (1,2,4-oxadiazol-5-yl) -S-isopropoxy carbonyl-1,4-dihydropyridine (IIb), (c) Trandolapril and felodipine; (D) Trandolapril and (IIb), (E) Trandolapril and Verapamil; (F) Quinapril and felodipine; (G) Quinapril and (IIIb) or the physiologically acceptable salts of these components.

公开(公告)号：AT176592T

公开(公告)日：1999-02-15

申请号：AT94117179

申请日：1991-11-21

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  URBACH HANSJOERG DR

IPC: A61K38/55 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/425 ,  A61K31/455 ,  A61K31/47 ,  A61K31/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00

Abstract: An angiotensin converting enzyme inhibitor (I) can be used in combination with Ca antagonists (III) in the prevention and therapy of proteinuria. Pref. (A) Ramipril and felodipine; (B) Ramipril and 4-(2,3-dichlorophenyl) -2,6-dimethyl-3- (1,2,4-oxadiazol-5-yl) -S-isopropoxy carbonyl-1,4-dihydropyridine (IIb), (c) Trandolapril and felodipine; (D) Trandolapril and (IIb), (E) Trandolapril and Verapamil; (F) Quinapril and felodipine; (G) Quinapril and (IIIb) or the physiologically acceptable salts of these components.

公开(公告)号：DE59209292D1

公开(公告)日：1998-05-28

申请号：DE59209292

申请日：1992-01-01

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD PROF DR ,  BECKER REINHARD DR ,  LINZ WOLFGANG DR ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：ES2043626T3

公开(公告)日：1994-01-01

申请号：ES87114164

申请日：1987-09-29

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  RUGER WOLFGANG DR ,  TEETZ WOLFGANG DR ,  URBACH HANSJORG DR

IPC: A61K31/40 ,  A61K31/401 ,  A61K31/435 ,  A61K31/44 ,  A61K38/05 ,  A61K38/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P43/00 ,  A61K37/64

Abstract: The combinations are produced as described and used as medicines.