公开(公告)号：SE370228B

公开(公告)日：1974-10-07

申请号：SE7270

申请日：1970-01-05

Applicant: HOECHST AG

Inventor： BECKER W

IPC: C07D301/28 ,  C07D303/20 ,  C07D303/22 ,  C07D303/24 ,  C08G59/00 ,  C08G59/06 ,  C07C43/20

公开(公告)号：NZ224184A

公开(公告)日：1989-10-27

申请号：NZ22418488

申请日：1988-04-08

Applicant: HOECHST AG

Inventor： WETEKAM W ,  JANSEN H W ,  BECKER W

IPC: C07K14/00 ,  C07K14/52 ,  C07K14/54 ,  C07K14/55 ,  C07K14/555 ,  C07K14/575 ,  C07K14/585 ,  C07K14/60 ,  C07K14/62 ,  C07K19/00 ,  C12N1/20 ,  C12N9/38 ,  C12N15/00 ,  C12N15/09 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00

Abstract: Fusion proteins containing beta -galactosidase or a beta -galactosidase fragment preferably having more than 250 amino acids, but significantly less than the total sequence of beta -galactosidase, and a eukaryotic, genetically encodable polypeptide are insoluble and easy to isolate from bacterial cells. The purification of the polypeptides can be simplified by replacing interfering codons for methionine and/or arginine and/or cysteine in the beta -galactosidase gene fraction by codons for other amino acids. Genetically encodable polypeptides can therefore be obtained by coupling the structural gene for the desired polypeptide in the correct reading frame, if necessary via an adapter, to a gene for such a beta -galactosidase derivative via a regulation region, expressing the insoluble fusion protein in a bacterium, isolating this protein after cell disruption and liberating the desired polypeptide by chemical or enzymatic cleavage. The cleavage can be facilitated by adding a "polyamino acid arm", which is arranged between the polypeptide and the beta -galactosidase component.

公开(公告)号：AU510762B2

公开(公告)日：1980-07-10

申请号：AU2639677

申请日：1977-06-23

Applicant: HOECHST AG

Inventor： HORLEIN G ,  BECKER W ,  LANGELUDDEKE P ,  KOCHER H ,  SACHSE B

IPC: C07C69/712 ,  A01N31/14 ,  A01N37/40 ,  A01N39/02 ,  A01P13/00 ,  C07C67/00 ,  C07C69/67 ,  C07C69/68 ,  C07C69/90 ,  C07C201/00 ,  C07C205/38 ,  C07C205/57 ,  C07C205/61 ,  C07C231/00 ,  C07C235/20 ,  C07C253/00 ,  C07C255/14 ,  C07C313/00 ,  C07C319/20 ,  C07C323/17 ,  C07C323/20 ,  C07C325/00 ,  C07C327/22 ,  C07D213/63 ,  C07C69/76 ,  A01N9/12 ,  A01N9/20 ,  C07C103/46 ,  C07C121/75 ,  C07C153/11

公开(公告)号：ZA773766B

公开(公告)日：1978-05-30

申请号：ZA773766

申请日：1977-06-23

Applicant: HOECHST AG

Inventor： SACHSE B ,  KOECHER H ,  LANGELUEDDEKE P ,  HOERLEIN G ,  BECKER W

IPC: C07C69/712 ,  A01N31/14 ,  A01N37/40 ,  A01N39/02 ,  A01P13/00 ,  C07C67/00 ,  C07C69/67 ,  C07C69/68 ,  C07C69/90 ,  C07C201/00 ,  C07C205/38 ,  C07C205/57 ,  C07C205/61 ,  C07C231/00 ,  C07C235/20 ,  C07C253/00 ,  C07C255/14 ,  C07C313/00 ,  C07C319/20 ,  C07C323/17 ,  C07C323/20 ,  C07C325/00 ,  C07C327/22 ,  C07D213/63 ,  C07C ,  A01N

公开(公告)号：SE385890B

公开(公告)日：1976-07-26

申请号：SE524472

申请日：1972-04-21

Applicant: HOECHST AG

Inventor： BECKER W

IPC: C07D301/28 ,  C07D303/22 ,  C07D303/24 ,  C08G59/06 ,  C07C43/20 ,  C07D303/02

公开(公告)号：SE379751B

公开(公告)日：1975-10-20

申请号：SE326171

申请日：1971-03-15

Applicant: HOECHST AG

Inventor： BECKER W

IPC: C07D301/28 ,  C07D303/22 ,  C07D303/24 ,  C08G59/06 ,  C07C43/20

Abstract: 1329178 Aromatic glycidyl ethers REICHHOLD-ALBERT-CHEMIE AG 19 April 1971 [16 March 1970] 22632/71 Heading C2C [Also in Division C3] Glycidyl ethers of monohydric phenols, and of dihydric phenols (see Division C3), are prepared by reacting 3-15 moles of epichlorhydrin with 1 mole of phenol in the presence of about one equivalent of alkali metal hydroxide which is added to the reaction mixture over 0À5 to 5 hours. Reaction takes place in the presence of choline or a choline salt as catalyst and in the presence of 2-8% by wt. of water at 50-110‹C. Excess epichlorhydrin is removed from the reaction mixture by distillation together with the water and the gylcidyl ether formed is isolated. An example relates to the preparation of the glycidyl ether of p-tert-butyl phenol.