公开(公告)号：AU6068486A

公开(公告)日：1987-02-05

申请号：AU6068486

申请日：1986-07-30

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOTTGER DIRK ,  SAUBER KLAUS

IPC: C07D311/92 ,  C12P17/06 ,  C12R1/645 ,  A61K31/35

Abstract: Forskolin analogues and derivatives are prepared by means of microbial transformations by microorganisms of the strain Neurospora crassa. The compounds prepared according to the invention have varied pharmacological effects and can therefore be used as medicaments.

公开(公告)号：AU4473485A

公开(公告)日：1986-01-16

申请号：AU4473485

申请日：1985-07-09

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BERSCHEID HANS GERD ,  FEHLHABER HANS-WOLFRAM ,  BOTTGER DIRK ,  KRAEMER HANS PETER

IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465 ,  A61K31/35 ,  A61K31/65 ,  C12P29/00

Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.