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    MOENOMYCIN DEGRADATION PRODUCTS HAVING A HYDROXYLATED OR OXIDIZED LIPID SIDE CHAIN AND MEONOMYCIN ANALOGS, A PROCESS FOR PREPARATION AND THE USE OF THESE COMPOUNDS
    6.
    发明专利
    MOENOMYCIN DEGRADATION PRODUCTS HAVING A HYDROXYLATED OR OXIDIZED LIPID SIDE CHAIN AND MEONOMYCIN ANALOGS, A PROCESS FOR PREPARATION AND THE USE OF THESE COMPOUNDS 未知

    公开(公告)号：CA2135041A1

    公开(公告)日：1995-05-05

    申请号：CA2135041

    申请日：1994-11-03

    Applicant: HOECHST AG

    Inventor： ARETZ WERNER ,  HEDTMANN UDO

    IPC: C07C59/60 ,  C07C59/90 ,  C07H3/06 ,  C07H11/04 ,  C07H13/12 ,  C12N1/16 ,  C12P7/42 ,  C12R1/645 ,  C12N1/20 ,  A61K31/70

    Abstract: MA having a hydroxylated or oxidized lipid side chain and moenomycin analogs, a process for preparation and the use of these compounds The invention relates to MA of the formula I I in which R1,R2,R4 and R5 independently of one another are a hydroxyl group or hydrogen and R3 is hydrogen, the bond between the carbon atom carrying the substituent R4 and the carbon atom carrying the substituent R5 being a single bond, or R1 and R2 independently of one another are a hydroxyl group or hydrogen and R3 is hydrogen, the bond between the carbon atom carrying the substituent R4 and the carbon atom carrying the substituent R5 being a double bond, or R1,R2 and R5 independently of one another are a hydroxyl group or hydrogen and R3 and R4 together are an oxo group MA is hydroxylated or oxidized in the lipid side chain by microorganisms of the genus Cryptococcus and in this form is a starting compound for the preparation of moenomycin analogs which can be employed as pharmaceuticals. The moenomycin analogs have the following chemical structure: II in which R1 to R5 have the abovementioned meaning>

    7.
    发明专利
    未知

    公开(公告)号：NO944197D0

    公开(公告)日：1994-11-03

    申请号：NO944197

    申请日：1994-11-03

    Applicant: HOECHST AG

    Inventor： ARETZ WERNER ,  HEDTMANN UDO

    IPC: C07C59/60 ,  C07C59/90 ,  C07H3/06 ,  C07H11/04 ,  C07H13/12 ,  C12N1/16 ,  C12P7/42 ,  C12R1/645 ,  C07C

    Abstract: The invention relates to MA of the formula I in which R , R , R and R independently of one another are a hydroxyl group or hydrogen and R is hydrogen, where the bond between the C atom carrying the substituent R and the C atom carrying the substituent R is a single bond, or R and R independently of one another are a hydroxyll group or hydrogen and R is hydrogen, where the bond between the C atom carrying the substituent R and the C atom carrying the substituent R is a double bond, or R , R and R independently of one another are a hydroxyl group or hydrogen and R and R together are an oxo group. MA is hydroxylated or oxidised in the lateral lipid chain by microorganisms of the order Cryptococcus and in this form is a starting compound for the preparation of moenomycin analogues which can be employed as medicaments. The moenomycin analogues have the following chemical structure: in which R to R have the abovementioned meanings.h

    PROCESS FOR THE PREPARATION OF MA
    9.
    发明专利
    PROCESS FOR THE PREPARATION OF MA 未知

    公开(公告)号：CA2062446A1

    公开(公告)日：1992-09-09

    申请号：CA2062446

    申请日：1992-03-06

    Applicant: HOECHST AG

    Inventor： ARETZ WERNER ,  EHLERS EBERHARD ,  HEDTMANN UDO

    IPC: C12N9/16 ,  C07C59/60 ,  C12P7/42

    Abstract: HOE 91/F 069 A process for the preparation of MA The invention relates to a process for the preparation of MA, which ensures MA production by enzymatic catalysis in glycine/NaOH buffer, and by the use of a phosphatecontaining culture medium for Bacillus sp. DSM 4675 and by extraction of the biomass with acetone.

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