公开(公告)号：PT91469B

公开(公告)日：1995-05-04

申请号：PT9146989

申请日：1989-08-17

Applicant: HOECHST AG

Inventor： SEIBERT GERHARD ,  ARETZ WERNER ,  BOTTGER DIRK ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C07F9/04

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：AU586977B2

公开(公告)日：1989-08-03

申请号：AU4473485

申请日：1985-07-09

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BERSCHEID HANS GERD ,  FEHLHABER HANS-WOLFRAM ,  BOTTGER DIRK ,  KRAEMER HANS PETER

IPC: C07C50/36 ,  A61K31/12 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07C45/00 ,  C07C67/00 ,  C07H15/252 ,  C12P7/26 ,  C12P19/56 ,  C12R1/465 ,  C12P29/00 ,  A61K31/35 ,  A61K31/65 ,  C07H15/24

Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.

公开(公告)号：AU3998589A

公开(公告)日：1990-02-22

申请号：AU3998589

申请日：1989-08-18

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOTTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C07F9/10 ,  C07F9/40 ,  A61K31/71 ,  C12P19/04 ,  C12P7/62

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：ES2000916A6

公开(公告)日：1988-04-01

申请号：ES8600109

申请日：1986-07-03

Applicant: HOECHST AG

Inventor： BERSCHEID HANS GERD ,  BOTTGER DIRK ,  KRAEMER HANS PETER

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P43/00 ,  C07H15/252 ,  C07H15/244 ,  A61K31/71

Abstract: EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA DONDER1 Y R2, DIFERENTES REPRESENTAN UNO EL RADICAL AZUCAL L-RODOSAMINA (ROA) Y EL OTRO REPRESENTA LA COMBINACION DE AZUCARES L-RODOSAMINA-L-RODINOSA-L-RODINOSA (ROA-ROD-ROD), L-RODOSAMINA-L-RODINOSA-L-ACULOSA (ROA-ROD-ACU) O L-RODOSAMINA-2-DESOXI-L-FUCOSA-L-CINERULOSA A (ROA-DF-CINA), SEPARANDO MEDIANTE TRATAMIENTO CON ACIDO EL DISACARIDO SITUADO EN POSICION EXTREMA EN UNA DE LAS DOS CADENAS DE TRISACARIDO DE UN COMPUESTO DE FORMULA: DONDE UNO DE R3 Y R4 REPRESENTA UNA COMBINACION DE AZUCARES ROA-ROD-ROD, ROA-ROD-ACU O ROA-DF-CINA Y EL OTRO REPRESENTA UNA COMBINACION DE AZUCARES ROA-ROD-ROD, ROA-ROD-ACU, ROA-DF-CINA, ROD-DF-CINB O ROA-DF-ROD, EN DONDE CINB REPRESENTACINERULOSA B Y DF CIN B SIGNIFICA QUE LOS DOS ESLABONES DE AZUCAR ESTAN UNIDOS MEDIANTE UN PUENTE ETER ADICIONAL JUNTO AL ENLACE GLICOSIDICO USUAL.LOS COMPUESTOS OBTENIDOS TIENEN ALTA ACTIVIDAD CITOSTATICA Y SON UTILES COMO MEDICAMENTOS ANTITUMORALES.

公开(公告)号：CA2075558C

公开(公告)日：2003-03-18

申请号：CA2075558

申请日：1992-08-07

Applicant: HOECHST AG

Inventor： ROSCHER GUNTER ,  KLEINER HANS-JERG ,  BERGER HARALD ,  SCHMIDT MANFRED ,  UHMANN RAINER ,  BOTTGER DIRK

IPC: C07F9/48 ,  C07F9/38 ,  C08G79/02 ,  C08G79/04

Abstract: Process for the preparation of pure propanephosphonic anhydride, which comprises distilling crude, impure propanephosphonic anhydride having an average degree of polymerization of 20 to 200 and containing less than 0.5% by weight of water by heating to 230 to 300.degree.C under a pressure of 0.1 to 100 mbar, pure propanephosphonic anhydride having an average decree of polymerization of 20 to 60 being obtained.

公开(公告)号：AU8835391A

公开(公告)日：1992-02-06

申请号：AU8835391

申请日：1991-12-02

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOTTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C07F9/10

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：AU619034B2

公开(公告)日：1992-01-16

申请号：AU3998589

申请日：1989-08-18

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOTTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C07F9/10 ,  C07F9/40 ,  A61K31/71 ,  C12P19/04 ,  C12P7/62

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：NZ230352A

公开(公告)日：1991-07-26

申请号：NZ23035289

申请日：1989-08-18

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  BOTTGER DIRK ,  SEIBERT GERHARD ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C07C59/01

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：PT91469A

公开(公告)日：1990-03-08

申请号：PT9146989

申请日：1989-08-17

Applicant: HOECHST AG

Inventor： SEIBERT GERHARD ,  ARETZ WERNER ,  BOTTGER DIRK ,  TUMULKA ALOIS ,  WELZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C12N1/00

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.

公开(公告)号：PH26511A

公开(公告)日：1992-08-07

申请号：PH39114

申请日：1989-08-18

Applicant: HOECHST AG

Inventor： ARETZ WERNER ,  TUMULKA ALOIS ,  BOTTGER DIRK ,  SEIBERT GERHARD ,  WEIZEL PETER ,  HOBERT KURT

IPC: A61K31/19 ,  A61P31/04 ,  C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C07H15/203 ,  C12N1/20 ,  C12N9/16 ,  C12N9/99 ,  C12P7/42 ,  C12P9/00 ,  C12P19/26 ,  C12P19/44 ,  C12R1/07 ,  C12N3/54

Abstract: It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.